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PLK1 and USP7
Number of citations of the paper that reports this interaction (PubMedID
29764989
)
71
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology)
PLK1
USP7
Description
polo like kinase 1
ubiquitin specific peptidase 7
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Kinetochore
Condensed Chromosome, Centromeric Region
Chromatin
Synaptonemal Complex
Spindle Pole
Outer Kinetochore
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Cytoskeleton
Spindle Microtubule
Microtubule Cytoskeleton
Midbody
Centriolar Satellite
Spindle Midzone
Mitotic Spindle Pole
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Nuclear Body
PML Body
Protein-containing Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Microtubule Binding
Anaphase-promoting Complex Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Serine Kinase Activity
P53 Binding
Cysteine-type Endopeptidase Activity
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Deubiquitinase Activity
K48-linked Deubiquitinase Activity
Biological Process
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Nuclear Division
Mitotic Cytokinesis
Double-strand Break Repair Via Homologous Recombination
Microtubule Bundle Formation
Double-strand Break Repair
Protein Phosphorylation
Mitotic Spindle Organization
Sister Chromatid Cohesion
Mitotic Chromosome Condensation
Mitotic Nuclear Membrane Disassembly
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Mitotic Spindle Assembly Checkpoint Signaling
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Female Meiosis Chromosome Segregation
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Regulation Of Mitotic Metaphase/anaphase Transition
Protein Destabilization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cytokinesis
Protein Localization To Organelle
Negative Regulation Of Apoptotic Process
Homologous Chromosome Segregation
Establishment Of Protein Localization
Positive Regulation Of Proteolysis
Golgi Inheritance
Nuclear Membrane Disassembly
Centrosome Separation
Cell Division
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cell Cycle
Synaptonemal Complex Disassembly
Protein Localization To Chromatin
Protein Localization To Centrosome
Protein Localization To Nuclear Envelope
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Spindle Assembly
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Regulation Of Protein Localization To Cell Cortex
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Protein Localization To Site Of Double-strand Break
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Autophagosome Assembly
DNA Repair
Transcription-coupled Nucleotide-excision Repair
DNA Alkylation Repair
Proteolysis
DNA Damage Response
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Protein Stability
Cellular Response To Nutrient Levels
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Monoubiquitinated Protein Deubiquitination
TORC1 Signaling
Regulation Of Circadian Rhythm
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Negative Regulation Of Gluconeogenesis
Rhythmic Process
Protein Stabilization
Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Establishment Of Protein Localization To Telomere
Symbiont-mediated Disruption Of Host Cell PML Body
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of TORC1 Signaling
Regulation Of Telomere Capping
Regulation Of Retrograde Transport, Endosome To Golgi
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
Mitotic Metaphase/Anaphase Transition
Mitotic Telophase/Cytokinesis
Cyclin A/B1/B2 associated events during G2/M transition
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
EML4 and NUDC in mitotic spindle formation
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Ub-specific processing proteases
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Regulation of PTEN localization
Drugs
3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
Wortmannin
Fostamatinib
Volasertib
Diseases
GWAS
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Appendicular lean mass (
33097823
)
Chronotype (
30696823
)
Lymphocyte count (
32888494
)
Mean platelet volume (
32888494
)
Platelet count (
27863252
32888494
)
Platelet distribution width (
27863252
32888494
)
Plateletcrit (
32888494
)
Interacting Genes
147 interacting genes:
-
ACTL6B
AKAP12
APP
ASPM
BAG6
BCL2L1
BIRC6
BRCA2
BUB1
C6orf136
CBL
CCNB1
CDC14A
CDC25C
CDC6
CEBPA
CENPQ
CENPU
CEP55
CHEK2
CSN1S1
CSN2
CTNNB1
CUL4B
DNAJB9
DNHD1
ECT2
EIF6
ERCC6L
EYA1
EYA4
FBXL5
FBXW7
GET4
GLB1
GORASP1
HNRNPU
IDH1
IDH2
IKBKB
INTS11
ITSN1
KIF23
KIF2C
KLF4
KLHL22
KRABD3
LMO4
LRP5L
LRRK1
LRRK2
MAD2L1BP
MAGED1
MCM2
MCM3
MCM7
MDM2
MISP
MPP2
MYC
MYT1
NCAPD3
NCAPG2
NCAPH2
NEDD1
NEDD4
NHSL2
NINL
NPM1
NUDC
PARP10
PHC2
PIN1
PITPNM1
PKMYT1
PON1
PPID
PPIL2
PPP1R12A
PPP6R2
PRC1
PRKN
PSMA1
PSMA3
PSMA4
PSMA5
PSMA6
PSMA7
PSMB1
PSMB2
PSMB3
PSMB4
PSMB5
PSMB6
PSMB7
PSRC1
PTEN
PTPRD
RAB1A
RABAC1
RACGAP1
RAD51
RAP1GAP
RECQL5
RELA
REST
RGCC
RICTOR
RNF126
RNF2
RSF1
RXRA
SEPTIN9
SHCBP1
SIMC1
SNCA
SNCB
SPOUT1
SREBF1
STAG2
STUB1
SUGT1
TIMELESS
TNFSF11
TOP2A
TP53
TP53BP2
TP73
TPT1
TRIOBP
TSC1
TUBA4A
TUBB
TUBB3
TUBG1
UBE2I
UHRF1
USP16
USP7
VIM
VMA22
VRK2
VRK3
WAC
WEE1
ZNF71
349 interacting genes:
ABCB1
ABRAXAS2
ACACB
ACD
ACLY
ADAR
ADARB1
AHNAK
AKIRIN1
ALB
ANKS1A
ANXA1
ANXA9
ARHGEF17
ARMC5
ARNT2
ASPM
ATXN1
AXIN1
BACH1
BCLAF1
BCOR
BEND5
BRPF1
BSN
CAMSAP1
CAV1
CBR1
CBX8
CCAR1
CCDC141
CCP110
CDC42BPA
CDC5L
CDR2L
CENPE
CEP250
CGNL1
CLSPN
CLTC
COBLL1
CREB3L3
CRY1
CSNK2A1
CTDP1
CTTN
DAXX
DBN1
DCD
DCTPP1
DDX17
DDX21
DDX24
DDX3X
DDX5
DDX50
DDX54
DDX60
DHX15
DHX30
DHX40
DHX9
DLST
DMD
DNAH5
DNAJA3
DNAJC16
DNHD1
DNMT3A
DSP
DST
DUSP2
DYRK1A
ECT2
EEA1
EEF1B2
EEF1D
EEF1G
EFCAB5
EFTUD2
ERCC6
ETS2
EWSR1
EXOSC10
FAM120C
FAM186A
FANCD2
FAT2
FAT3
FBXO38
FER1L6
FLG2
FMR1
FOXM1
FOXN2
FXR1
GATA1
GIGYF2
GMPS
GNL3
GOLGB1
GON4L
GRM1
GRWD1
GTF2I
GTPBP4
H2AC20
H2BC26
H2BC3
H3C1
HECW1
HERC1
HERPUD1
HMOX1
HNRNPC
HNRNPL
HNRNPM
HNRNPR
HRNR
HSPA9
HTRA2
IFNAR1
IGF2BP1
IGF2BP3
IGHG1
IKZF1
ILF3
IPCEF1
KDR
KHDRBS1
KIAA1549L
KIF13A
KLF12
KLHL5
KLHL8
KMT2D
KRI1
LAMA1
LEPR
LIMA1
LINC02582
LINGO2
LPIN3
LRBA
LTF
LTV1
LUC7L3
MACF1
MAGEE1
MAL
MARCHF7
MAST2
MATR3
MCMBP
MDC1
MDM2
MDM4
MDN1
MEX3B
MINK1
MLF2
MPRIP
MTREX
MYBBP1A
MYC
MYD88
MYH13
MYO1B
MYO5A
MYO7B
NAT10
NEB
NECAB2
NEDD4L
NGEF
NKRF
NLRP11
NOM1
NOP2
NSD1
NUMA1
OGDH
OTOF
OTUD4
OVCH1
PABPC1
PARP1
PBRM1
PC
PCARE
PCGF2
PCLAF
PDE3A
PEG3
PELP1
PEPD
PES1
PHLDB2
PICK1
PIP
PKM
PLA2G2A
PLCH1
PLEC
PLEKHO1
PLK1
PNN
PNPLA4
POLI
POP1
PPARG
PPFIA1
PPIP5K1
PPL
PPP1R12A
PRDM16
PRPF19
PRPF40A
PRPF8
PSIP1
PTEN
PWP1
RAD18
RAD50
RADIL
RAF1
RAI14
RALY
RARA
RB1
RBBP4
RBCK1
RBM15
RBM39
RCC2
RELA
RFC1
RFFL
RGPD8
RNF168
RNF220
RPL7A
RPLP0
RPS3
RPS4X
RPS6
RSL1D1
RSPH1
SALL1
SAMHD1
SAP130
SAP30BP
SCML2
SDK2
SENP1
SERBP1
SF3B1
SF3B2
SF3B3
SHOC2
SIRT5
SLC15A1
SLC38A6
SLC4A5
SLIT2
SMAD3
SMARCA4
SMARCA5
SMARCC1
SMARCC2
SNCA
SNRNP200
SNRNP70
SNX25
SOX9
SP4
SRPK1
SRRM2
SRSF4
STAU1
SUMO2
SUPT16H
SYCP1
SYNE1
SYT14
SYVN1
TANK
TBCB
TERT
TEX15
TFIP11
THOC2
THRAP3
TMPO
TNPO3
TOP2A
TOP2B
TP53
TPM4
TPR
TPX2
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
TRIM22
TRIM31
TRIM54
TRIM55
TRIM63
TRIM8
TRO
TSC22D2
TTN
U2AF2
UBA52
UBAP2
UBC
UBE2D3
UBE2E1
UBE2S
UBN1
UBTF
UHRF1
UMPS
USP21
USP28
UTP14C
UTY
VARS1
VCP
VIM
VIRMA
VPS13B
VPS35
WWP2
XPC
XRN2
YY1
ZC3HAV1
ZFR
ZGRF1
ZMYM1
ZMYND8
ZNF335
ZNF423
ZNF76
Entrez ID
5347
7874
HPRD ID
03652
03950
Ensembl ID
ENSG00000166851
ENSG00000187555
Uniprot IDs
P53350
B7Z855
B7ZAX6
Q6U8A4
Q93009
PDB IDs
1Q4K
1Q4O
1UMW
2OGQ
2OJX
2OU7
2OWB
2RKU
2V5Q
2YAC
3BZI
3C5L
3FC2
3FVH
3HIH
3HIK
3KB7
3P2W
3P2Z
3P34
3P35
3P36
3P37
3Q1I
3RQ7
3THB
4A4L
4A4O
4DFW
4E67
4E9C
4E9D
4H5X
4H71
4HAB
4HCO
4HY2
4J52
4J53
4LKL
4LKM
4O56
4O6W
4O9W
4RCP
4WHH
4WHK
4WHL
4X9R
4X9V
4X9W
5J19
5NEI
5NFU
5NJE
5NMM
5NN1
5NN2
5TA6
5TA8
6AX4
6GY2
7MSO
7MX1
8BJT
8CRC
8JOQ
8JOY
8S30
8S31
8WFP
8X72
8XB9
1NB8
1NBF
1YY6
1YZE
2F1W
2F1X
2F1Y
2F1Z
2FOJ
2FOO
2FOP
2KVR
2XXN
2YLM
3MQR
3MQS
4JJQ
4KG9
4M5W
4M5X
4PYZ
4WPH
4WPI
4YOC
4YSI
4Z96
4Z97
5C56
5C6D
5FWI
5GG4
5J7T
5JTJ
5JTV
5KYB
5KYC
5KYD
5KYE
5KYF
5N9R
5N9T
5NGE
5NGF
5UQV
5UQX
5VS6
5VSB
5VSK
5WHC
6F5H
6M1K
6P5L
6VN2
6VN3
6VN4
6VN5
6VN6
7CM2
7VIJ
7XHH
7XHK
7XPY
8D4Z
9DEK
9DEL
9DEM
9DEN
9DEO
9DEP
9FIO
9FIP
9FIQ
9FIR
9FIS
9FIT
9FIU
9FIV
9IJU
9IML
Enriched GO Terms of Interacting Partners
?
Proteasome Core Complex
Cell Division
Cytoplasm
Regulation Of Cell Cycle
Nucleoplasm
Regulation Of Cell Cycle Process
Nucleus
Cytosol
Cellular Response To Stress
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Proteasome Complex
Proteasomal Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
DNA Damage Response
Macromolecule Catabolic Process
Positive Regulation Of Cell Cycle
Proteasome Core Complex, Beta-subunit Complex
Positive Regulation Of Cell Cycle Process
Regulation Of Mitotic Cell Cycle
Spindle
Regulation Of Cell Cycle Phase Transition
Proteasome Core Complex, Alpha-subunit Complex
Regulation Of Cellular Response To Stress
Microtubule-based Process
Organelle Organization
Centrosome
Cytoskeleton
Microtubule Cytoskeleton Organization
Midbody
Proteolysis
Regulation Of Intracellular Signal Transduction
Cellular Response To Radiation
DNA Repair
Chromosome Segregation
Regulation Of Chromosome Organization
Regulation Of Cytokinesis
Macromolecule Metabolic Process
Response To Xenobiotic Stimulus
Regulation Of Organelle Organization
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Chromosome Segregation
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Cell Cycle
Positive Regulation Of Programmed Cell Death
Protein Kinase Binding
Chromosome
Regulation Of Chromosome Segregation
Nucleus
RNA Binding
Nucleoplasm
Nucleic Acid Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Nucleolus
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
RNA Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
RNA Processing
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
MRNA Processing
MRNA Metabolic Process
Chromatin Organization
RNA Splicing, Via Transesterification Reactions
MRNA Splicing, Via Spliceosome
Positive Regulation Of RNA Biosynthetic Process
RNA Splicing
Catalytic Step 2 Spliceosome
Positive Regulation Of DNA-templated Transcription
Nucleic Acid Binding
Cellular Response To Stress
MRNA Binding
Negative Regulation Of DNA-templated Transcription
Response To Stress
Negative Regulation Of RNA Biosynthetic Process
DNA Damage Response
DNA Metabolic Process
Chromatin Remodeling
Protein-containing Complex
Spliceosomal Complex
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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