PLK1 and BAG6

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PLK1	BAG6
Gene Name		polo-like kinase 1	BCL2-associated athanogene 6
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Gene Ontology Annotations	Cellular Component	Kinetochore Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody Spindle Midzone	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle BAT3 Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Anaphase-promoting Complex Binding Kinase Activity Protein Kinase Binding	Protein Binding Hsp70 Protein Binding Polyubiquitin Binding Ubiquitin Protein Ligase Binding Ribosome Binding Proteasome Binding
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Mitotic Cytokinesis Cytokinesis Microtubule Bundle Formation Protein Phosphorylation Organelle Organization Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Metaphase/anaphase Transition Of Mitotic Cell Cycle Activation Of APC-Cdc20 Complex Activity Mitotic Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Cell Proliferation Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G2 DNA Damage Checkpoint Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Polar Body Extrusion After Meiotic Divisions Negative Regulation Of Apoptotic Process Regulation Of Protein Binding Establishment Of Protein Localization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Proteolysis Response To Antibiotic Centrosome Organization Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Protein Localization To Chromatin	Kidney Development Immune System Process Ubiquitin-dependent Protein Catabolic Process Transport Synaptonemal Complex Assembly Spermatogenesis Brain Development Embryo Development Chromatin Modification Internal Peptidyl-lysine Acetylation Cell Differentiation Lung Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Protein Stabilization Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Phosphorylation of the APC/C Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Organelle biogenesis and maintenance Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown G2/M Transition Mitotic Metaphase/Anaphase Transition Phosphorylation of Emi1 Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition M Phase Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Assembly of the primary cilium Regulation of APC/C activators between G1/S and early anaphase Anchoring of the basal body to the plasma membrane APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Centrosome maturation Condensation of Prophase Chromosomes Mitotic G2-G2/M phases Polo-like kinase mediated events Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			Schizophrenia ( 23894747)
Protein-Protein Interactions		99 interactors: ACTL6B APP ASPM BAG6 BIRC6 BRCA2 BUB1 C6orf136 C9orf114 CCDC115 CCNB1 CDC20 CDC25C CENPQ CENPU CEP55 CHEK2 CIC CPSF3L CSN1S1 CSN2 CTNNB1 DNAJB9 DNHD1 ECT2 EIF6 FBXL5 FLJ20712 FZR1 GET4 GLB1 GORASP1 HSF1 IKBKB ITSN1 KIF23 KLHL22 KRBA1 LMO4 LRP5L MAGED1 MAPK6 MCM2 MCM3 MCM7 MDM2 MPP2 MYT1 NEDD4 NINL NPM1 NUDC OFD1 PHC2 PIN1 PITPNM1 PKMYT1 PPID PRC1 PSMA1 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 RABAC1 RAP1GAP RBX1 RECQL5 RELA RNF126 RXRA SIMC1 SNCA SNCB STAG2 SUGT1 TANK TNFSF11 TP53 TP53BP1 TP53BP2 TPT1 TRIOBP TSC1 TUBA4A TUBB TUBB3 TUBG1 VRK3 WEE1 ZNF71	102 interactors: ACVR1B AMFR ANXA7 ARPC3 ATN1 ATXN2 B2M C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CHN2 CLU CSNK2B CSTF2 CTCFL CTSB CTSE CTSL CXCL8 DNAJB11 DPT EDN1 EFEMP1 EFEMP2 EP300 FAM173A FAM46A FAM9B FAS FKBP2 FZD4 GADD45A GLRA2 GSK3B HSPA13 HSPA8 ICK IGF2 IGFBP5 IKBKAP IMMT IQCG KLHL12 LBP LPPR3 MAPK6 MAVS MEST MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 POLR2J PPAP2C PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TDGF1 TFCP2 TK1 TOMM20 TP63 TTR UBL4A UBL7 UBQLN4 VAMP2 XRN1 ZFYVE9
Entrez ID		5347	7917
HPRD ID		03652	00808
Ensembl ID		ENSG00000166851	ENSG00000204463
Uniprot IDs		P53350	P46379
PDB IDs		1Q4K 1Q4O 1UMW 2OGQ 2OJX 2OU7 2OWB 2RKU 2V5Q 2YAC 3BZI 3C5L 3FC2 3FVH 3HIH 3HIK 3KB7 3P2W 3P2Z 3P34 3P35 3P36 3P37 3Q1I 3RQ7 3THB 4A4L 4A4O 4DFW 4E67 4E9C 4E9D 4H5X 4H71 4HAB 4HCO 4HY2 4J52 4J53	1WX9 4DWF 4EEW
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Signal Transduction By P53 Class Mediator Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic G1 DNA Damage Checkpoint Negative Regulation Of Cellular Metabolic Process Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Mitotic DNA Integrity Checkpoint Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Positive Regulation Of Protein Ubiquitination Negative Regulation Of Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Proteasomal Protein Catabolic Process DNA Damage Checkpoint	Response To Organic Substance Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signaling Cell Communication Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Immune Response Regulation Of Immune System Process Regulation Of Protein Phosphorylation Cellular Response To Stimulus Defense Response Regulation Of Signaling Anatomical Structure Development Positive Regulation Of Cellular Protein Metabolic Process Innate Immune Response Regulation Of Cell Cycle Response To External Stimulus Signal Transduction Developmental Process Positive Regulation Of Phosphorylation Response To Organic Cyclic Compound Regulation Of Cellular Component Organization Positive Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Cell Development System Development Regulation Of Phosphorylation Regulation Of Signal Transduction Response To Hormone Immune System Process Response To Lipid Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Protein Metabolic Process Regulation Of Cellular Process Cellular Process Regulation Of Catalytic Activity Response To Abiotic Stimulus Positive Regulation Of Metabolic Process Regulation Of Cell Motility Apoptotic Signaling Pathway Multicellular Organismal Development Positive Regulation Of Signal Transduction
Tagcloud ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic properly recombination rnf168 rnf8 s1618 spatiotemporally ubiquitinated	biochemically biophysical calorimetry compete connecting decided dimerisation glutamine haddock helices hydrophobic isothermal itc microscale mst nt paths perturbation resides sgta solve tetratricopeptide thermophoresis titration tpr trc35 trimeric ubl ubl4a
Tagcloud (Difference) ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic properly recombination rnf168 rnf8 s1618 spatiotemporally ubiquitinated	biochemically biophysical calorimetry compete connecting decided dimerisation glutamine haddock helices hydrophobic isothermal itc microscale mst nt paths perturbation resides sgta solve tetratricopeptide thermophoresis titration tpr trc35 trimeric ubl ubl4a
Tagcloud (Intersection) ?