PLK1 and ITSN1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PLK1	ITSN1
Gene Name		polo-like kinase 1	intersectin 1 (SH3 domain protein)
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody Spindle Midzone	Cytosol Plasma Membrane Coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuron Projection Synapse
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Anaphase-promoting Complex Binding Kinase Activity Protein Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Protein Complex Scaffold Proline-rich Region Binding
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Mitotic Cytokinesis Cytokinesis Microtubule Bundle Formation Protein Phosphorylation Organelle Organization Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Metaphase/anaphase Transition Of Mitotic Cell Cycle Activation Of APC-Cdc20 Complex Activity Mitotic Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Cell Proliferation Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G2 DNA Damage Checkpoint Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Polar Body Extrusion After Meiotic Divisions Negative Regulation Of Apoptotic Process Regulation Of Protein Binding Establishment Of Protein Localization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Proteolysis Response To Antibiotic Centrosome Organization Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Protein Localization To Chromatin	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways		Phosphorylation of the APC/C Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Organelle biogenesis and maintenance Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown G2/M Transition Mitotic Metaphase/Anaphase Transition Phosphorylation of Emi1 Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition M Phase Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Assembly of the primary cilium Regulation of APC/C activators between G1/S and early anaphase Anchoring of the basal body to the plasma membrane APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Centrosome maturation Condensation of Prophase Chromosomes Mitotic G2-G2/M phases Polo-like kinase mediated events Mitotic Metaphase and Anaphase	Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		99 interactors: ACTL6B APP ASPM BAG6 BIRC6 BRCA2 BUB1 C6orf136 C9orf114 CCDC115 CCNB1 CDC20 CDC25C CENPQ CENPU CEP55 CHEK2 CIC CPSF3L CSN1S1 CSN2 CTNNB1 DNAJB9 DNHD1 ECT2 EIF6 FBXL5 FLJ20712 FZR1 GET4 GLB1 GORASP1 HSF1 IKBKB ITSN1 KIF23 KLHL22 KRBA1 LMO4 LRP5L MAGED1 MAPK6 MCM2 MCM3 MCM7 MDM2 MPP2 MYT1 NEDD4 NINL NPM1 NUDC OFD1 PHC2 PIN1 PITPNM1 PKMYT1 PPID PRC1 PSMA1 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 RABAC1 RAP1GAP RBX1 RECQL5 RELA RNF126 RXRA SIMC1 SNCA SNCB STAG2 SUGT1 TANK TNFSF11 TP53 TP53BP1 TP53BP2 TPT1 TRIOBP TSC1 TUBA4A TUBB TUBB3 TUBG1 VRK3 WEE1 ZNF71	82 interactors: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHSD2 FNBP1 FNBP4 GAREML GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZAK ZFPM2
Entrez ID		5347	6453
HPRD ID		03652	03898
Ensembl ID		ENSG00000166851	ENSG00000205726
Uniprot IDs		P53350	A7XZY7 F8W7U0 Q15811 Q6PD56
PDB IDs		1Q4K 1Q4O 1UMW 2OGQ 2OJX 2OU7 2OWB 2RKU 2V5Q 2YAC 3BZI 3C5L 3FC2 3FVH 3HIH 3HIK 3KB7 3P2W 3P2Z 3P34 3P35 3P36 3P37 3Q1I 3RQ7 3THB 4A4L 4A4O 4DFW 4E67 4E9C 4E9D 4H5X 4H71 4HAB 4HCO 4HY2 4J52 4J53	1KI1 2KGR 2KHN 3FIA 3QBV 4IIM
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Signal Transduction By P53 Class Mediator Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic G1 DNA Damage Checkpoint Negative Regulation Of Cellular Metabolic Process Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Mitotic DNA Integrity Checkpoint Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Positive Regulation Of Protein Ubiquitination Negative Regulation Of Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Proteasomal Protein Catabolic Process DNA Damage Checkpoint	Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Vesicle Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Signaling Synaptic Transmission Regulation Of Cellular Component Organization Establishment Of Organelle Localization Cell Communication Regulation Of Signaling Organelle Organization Protein Localization Cell Differentiation Synaptic Vesicle Transport Cell-cell Signaling Membrane Budding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Localization Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle Localization Transport Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Generation Of Neurons Cell Morphogenesis Involved In Differentiation Membrane Organization Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Protein Localization Cell Projection Organization Synaptic Vesicle Recycling Axonogenesis Cellular Protein Complex Assembly Neurogenesis Regulation Of Catalytic Activity Regulation Of Signal Transduction Intracellular Transport Cell Morphogenesis
Tagcloud ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic properly recombination rnf168 rnf8 s1618 spatiotemporally ubiquitinated	cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Difference) ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic properly recombination rnf168 rnf8 s1618 spatiotemporally ubiquitinated	cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Intersection) ?