PLK1 and TSC1

Number of citations of the paper that reports this interaction (PMID 16339216)
15

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		PLK1	TSC1
Gene Name		polo-like kinase 1	tuberous sclerosis 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody Spindle Midzone	Cytoplasm Cytosol Actin Filament Plasma Membrane Cell Cortex Membrane Lamellipodium Growth Cone TSC1-TSC2 Complex Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Anaphase-promoting Complex Binding Kinase Activity Protein Kinase Binding	Protein Binding GTPase Regulator Activity GTPase Activating Protein Binding Protein N-terminus Binding Chaperone Binding
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Mitotic Cytokinesis Cytokinesis Microtubule Bundle Formation Protein Phosphorylation Organelle Organization Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Metaphase/anaphase Transition Of Mitotic Cell Cycle Activation Of APC-Cdc20 Complex Activity Mitotic Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Cell Proliferation Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G2 DNA Damage Checkpoint Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Polar Body Extrusion After Meiotic Divisions Negative Regulation Of Apoptotic Process Regulation Of Protein Binding Establishment Of Protein Localization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Proteolysis Response To Antibiotic Centrosome Organization Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Protein Localization To Chromatin	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell Cycle Arrest Cell-matrix Adhesion Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Activation Of Rho GTPase Activity Response To Insulin Myelination Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Synapse Organization Protein Stabilization Protein Heterooligomerization Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation
Pathways		Phosphorylation of the APC/C Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Organelle biogenesis and maintenance Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown G2/M Transition Mitotic Metaphase/Anaphase Transition Phosphorylation of Emi1 Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition M Phase Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Assembly of the primary cilium Regulation of APC/C activators between G1/S and early anaphase Anchoring of the basal body to the plasma membrane APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Centrosome maturation Condensation of Prophase Chromosomes Mitotic G2-G2/M phases Polo-like kinase mediated events Mitotic Metaphase and Anaphase	Inhibition of TSC complex formation by PKB Insulin receptor signalling cascade IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling IRS-related events mTOR signalling Inhibition of TSC complex formation by PKB IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS			Psoriasis ( 19169254)
Protein-Protein Interactions		99 interactors: ACTL6B APP ASPM BAG6 BIRC6 BRCA2 BUB1 C6orf136 C9orf114 CCDC115 CCNB1 CDC20 CDC25C CENPQ CENPU CEP55 CHEK2 CIC CPSF3L CSN1S1 CSN2 CTNNB1 DNAJB9 DNHD1 ECT2 EIF6 FBXL5 FLJ20712 FZR1 GET4 GLB1 GORASP1 HSF1 IKBKB ITSN1 KIF23 KLHL22 KRBA1 LMO4 LRP5L MAGED1 MAPK6 MCM2 MCM3 MCM7 MDM2 MPP2 MYT1 NEDD4 NINL NPM1 NUDC OFD1 PHC2 PIN1 PITPNM1 PKMYT1 PPID PRC1 PSMA1 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 RABAC1 RAP1GAP RBX1 RECQL5 RELA RNF126 RXRA SIMC1 SNCA SNCB STAG2 SUGT1 TANK TNFSF11 TP53 TP53BP1 TP53BP2 TPT1 TRIOBP TSC1 TUBA4A TUBB TUBB3 TUBG1 VRK3 WEE1 ZNF71	23 interactors: AKT1 ATXN1 CCNB1 CDK1 EZR IKBKB KDM1A MSN NEFL NF2 NGFRAP1 PLK1 PRMT6 RDX RHEB TBC1D7 TSC2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		5347	7248
HPRD ID		03652	05594
Ensembl ID		ENSG00000166851	ENSG00000165699
Uniprot IDs		P53350	Q32NF0 Q86WV8 Q92574
PDB IDs		1Q4K 1Q4O 1UMW 2OGQ 2OJX 2OU7 2OWB 2RKU 2V5Q 2YAC 3BZI 3C5L 3FC2 3FVH 3HIH 3HIK 3KB7 3P2W 3P2Z 3P34 3P35 3P36 3P37 3Q1I 3RQ7 3THB 4A4L 4A4O 4DFW 4E67 4E9C 4E9D 4H5X 4H71 4HAB 4HCO 4HY2 4J52 4J53
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Signal Transduction By P53 Class Mediator Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic G1 DNA Damage Checkpoint Negative Regulation Of Cellular Metabolic Process Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Mitotic DNA Integrity Checkpoint Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Positive Regulation Of Protein Ubiquitination Negative Regulation Of Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Proteasomal Protein Catabolic Process DNA Damage Checkpoint	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Regulation Of Apoptotic Process Membrane Organization Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Localization Neurotrophin Signaling Pathway Regulation Of Signal Transduction Cellular Localization Regulation Of Intracellular Transport Regulation Of Signaling Positive Regulation Of Transport Cellular Protein Localization Regulation Of Cellular Localization Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Protein Localization Cellular Response To Insulin Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Response To Growth Factor Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Cell Death Negative Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Protein Targeting G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Phase Transition Apoptotic Process Regulation Of Cellular Process Cell Cycle Phase Transition Response To Peptide Hormone
Tagcloud ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic properly recombination rnf168 rnf8 s1618 spatiotemporally ubiquitinated	abnormally autosomal deprived formations glutamine hamartin immunosuppressant impairments indicators lifespan master mechanistically mtorc1 neurocognitive neuropsychological orally physiologically premature rapamycin s6 seizures starvation surrogate tsc2 tuber tuberin tuberous withdrawal
Tagcloud (Difference) ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic properly recombination rnf168 rnf8 s1618 spatiotemporally ubiquitinated	abnormally autosomal deprived formations glutamine hamartin immunosuppressant impairments indicators lifespan master mechanistically mtorc1 neurocognitive neuropsychological orally physiologically premature rapamycin s6 seizures starvation surrogate tsc2 tuber tuberin tuberous withdrawal
Tagcloud (Intersection) ?