NUMB and LNX2

Number of citations of the paper that reports this interaction (PubMedID 11782429)
44

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		NUMB	LNX2
Description		NUMB endocytic adaptor protein	ligand of numb-protein X 2
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Plasma Membrane Clathrin-coated Pit Focal Adhesion Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Apical Part Of Cell Glutamatergic Synapse	Plasma Membrane
	Molecular Function	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Nervous System Development Neuroblast Proliferation Axonogenesis Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Forebrain Development Adherens Junction Organization Positive Regulation Of Neurogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane	Nervous System Development Neuron Differentiation Neural Precursor Cell Proliferation
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984) Coronary artery calcification ( 17903303) Hemoglobin ( 32888494) Macular thickness ( 30535121) Multisite chronic pain ( 31194737 33830993) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 27863252 32888494) Night sleep phenotypes ( 27126917) Platelet distribution width ( 27863252 32888494) Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		38 interacting genes: AP2A1 AP2A2 APP DPYSL2 EAF1 EGFR EPS15 FBXO7 FRS3 IQGAP1 IRS1 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MAPK8IP2 MDM2 NEDD4 NOTCH1 NRON OLIG1 PALS1 PDZK1IP1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ PTEN RPL3 SIAH1 SPANXN2 TERF2	90 interacting genes: ATP5F1B C10orf88 CABP4 CBX4 CCT3 CDK2 CDK4 CDKN2C CRK CXADR DDA1 DRAP1 EAF2 FANCG FHL3 GADD45A GJD2 GLRX3 GRAP2 GRB2 IGSF5 IL16 INMT IP6K2 L3MBTL2 LGALS14 LNX1 LRRC8E MAP2K5 MAPK9 MCM7 MDGA1 MECOM MLX MRFAP1L1 MSRB3 MYLIP NAGK NMD3 NOTCH1 NTAQ1 NUDT14 NUMB OPTN PARVG PDZRN3 PDZRN4 PEG10 PHYKPL PIK3R1 PIK3R3 PKDREJ POLR1C PPIH PPIL1 PSMD5 PSMF1 PTCD3 RAB6B RBM17 RLIM RNF138 ROPN1 RPA2 SCLY SCNM1 SFN SH3GLB2 SHISA2 SHTN1 SMARCB1 SRSF11 TAB1 TBC1D7 TCL1A TIFA TRAF1 TRAF2 TUBB UBE2D2 UBE2H UBE2I UBE2T UBE2Z USP2 VTN YJU2 ZNF148 ZNF410 ZNF581
Entrez ID		8650	222484
HPRD ID		04767	10042
Ensembl ID		ENSG00000133961	ENSG00000139517
Uniprot IDs		P49757	Q8N448
PDB IDs		5NJJ 5NJK	2VWR 5DIN 5E11 5E1Y 5E21 5E22 7QCT
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Enzyme Binding Plasma Membrane Receptor Internalization Positive Regulation Of Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein-containing Complex Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Apical Plasma Membrane Positive Regulation Of Signal Transduction Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Regulation Of Protein Localization Regulation Of Signaling Negative Regulation Of Programmed Cell Death Endocytosis Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Superoxide Metabolic Process Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of MAPK Cascade Regulation Of Apoptotic Process Regulation Of Signal Transduction Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Ubiquitin-protein Transferase Activity Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death AP-2 Adaptor Complex Positive Regulation Of Metabolic Process Regulation Of Cell Communication Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Apoptotic Process Positive Regulation Of Catabolic Process Extracellular Exosome Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Transport Programmed Cell Death Cell Death Negative Regulation Of Insulin Receptor Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Cellular Response To Insulin Stimulus	Nucleoplasm Phosphotyrosine Residue Binding Post-translational Protein Modification Nucleus Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Cytosol Ubiquitin-protein Transferase Activity Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Nuclear Speck Protein Ubiquitination Identical Protein Binding Response To Nitric Oxide Transferase Activity Cytoplasm
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