NUMB

Name	NUMB endocytic adaptor protein
Structure
Interactors	38 interactors: AP2A1 AP2A2 APP DPYSL2 EAF1 EGFR EPS15 FBXO7 FRS3 IQGAP1 IRS1 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MAPK8IP2 MDM2 NEDD4 NOTCH1 NRON OLIG1 PALS1 PDZK1IP1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ PTEN RPL3 SIAH1 SPANXN2 TERF2
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Plasma Membrane Clathrin-coated Pit Focal Adhesion Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Apical Part Of Cell Glutamatergic Synapse
	Molecular Function	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Nervous System Development Neuroblast Proliferation Axonogenesis Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Forebrain Development Adherens Junction Organization Positive Regulation Of Neurogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane
Pathways	Activated NOTCH1 Transmits Signal to the Nucleus Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
GWAS	Bipolar disorder with mood-incongruent psychosis ( 23092984 ) Coronary artery calcification ( 17903303 ) Hemoglobin ( 32888494 ) Macular thickness ( 30535121 ) Multisite chronic pain ( 31194737 33830993 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )
Entrez ID	8650
HPRD ID	04767
Ensembl ID	ENSG00000133961
Uniprot IDs	P49757
PDB IDs	5NJJ 5NJK
GO Terms Enriched among Interactors ?	Diacylglycerol-dependent Serine/threonine Kinase Activity Enzyme Binding Plasma Membrane Receptor Internalization Positive Regulation Of Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein-containing Complex Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Apical Plasma Membrane Positive Regulation Of Signal Transduction Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Regulation Of Protein Localization Regulation Of Signaling Negative Regulation Of Programmed Cell Death Endocytosis Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Superoxide Metabolic Process Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of MAPK Cascade Regulation Of Apoptotic Process Regulation Of Signal Transduction Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Ubiquitin-protein Transferase Activity Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death AP-2 Adaptor Complex Positive Regulation Of Metabolic Process Regulation Of Cell Communication Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Apoptotic Process Positive Regulation Of Catabolic Process Extracellular Exosome Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Transport Programmed Cell Death Cell Death Negative Regulation Of Insulin Receptor Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Cellular Response To Insulin Stimulus