NUMB and RPL3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NUMB	RPL3
Gene Name		numb homolog (Drosophila)	ribosomal protein L3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Apical Part Of Cell	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Focal Adhesion Cytosolic Large Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding	RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding
	Biological Process	Notch Signaling Pathway Axon Guidance Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Positive Regulation Of Polarized Epithelial Cell Differentiation Adherens Junction Organization Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Neurogenesis Lung Epithelial Cell Differentiation Negative Regulation Of Protein Localization To Plasma Membrane	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process Cellular Response To Interleukin-4
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH L1CAM interactions Recycling pathway of L1 Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Degradation of GLI1 by the proteasome Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Bipolar disorder (mood-incongruent) ( 23092984) Coronary artery calcification ( 17903303)
Protein-Protein Interactions		24 interactors: AP2A1 AP2A2 APP DPYSL2 EGFR EPS15 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MDM2 NOTCH1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ RPL3 SIAH1	4 interactors: NDRG1 NUMB SIK1 STXBP3
Entrez ID		8650	6122
HPRD ID		04767	16042
Ensembl ID		ENSG00000133961	ENSG00000100316
Uniprot IDs		P49757	B3KS36 P39023 Q96QL0
PDB IDs			3J3B
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Blood Coagulation Hemostasis Response To Growth Factor Wound Healing Platelet Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Activation Response To Wounding Regulation Of Immune System Process Regulation Of Body Fluid Levels Immune System Process Cell Surface Receptor Signaling Pathway Response To External Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Locomotion Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Signaling Regulation Of Phospholipase Activity Chemotaxis Positive Regulation Of Lipase Activity Neuron Projection Morphogenesis Signal Transduction Cellular Response To Organic Substance Signaling Response To Organic Substance Axonogenesis Defense Response Activation Of Phospholipase C Activity Cell Communication Cellular Response To Stimulus Axon Development Neuron Projection Development Innate Immune Response Negative Regulation Of Signal Transduction Axon Guidance Positive Regulation Of Phospholipase C Activity Regulation Of Cellular Amino Acid Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Part Morphogenesis Negative Regulation Of Signaling Response To Stimulus	Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Polarized Epithelial Cell Differentiation Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of Anoikis Neuroblast Division In Subventricular Zone System Development Positive Regulation Of Spindle Checkpoint Neutrophil Degranulation Protein To Membrane Docking Neutrophil Activation Involved In Immune Response Positive Regulation Of Cell Cycle Checkpoint Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Gluconeogenesis Forebrain Neuroblast Division Leukocyte Activation Developmental Process Regulation Of Anoikis Regulation Of Triglyceride Biosynthetic Process Peripheral Nervous System Myelin Maintenance Signaling Negative Regulation Of Calcium Ion-dependent Exocytosis Nervous System Development Negative Regulation Of Protein Localization To Plasma Membrane Neutrophil Mediated Immunity Cell Communication Lateral Ventricle Development Neutrophil Activation Entrainment Of Circadian Clock By Photoperiod Regulation Of Spindle Checkpoint Somatic Stem Cell Division Photoperiodism Entrainment Of Circadian Clock Cell Activation Myelin Maintenance Negative Regulation Of Notch Signaling Pathway Mast Cell Activation Regulation Of Triglyceride Metabolic Process Brain Development Regulation Of Cell Cycle Checkpoint Negative Regulation Of Exocytosis Head Development Platelet Aggregation Stem Cell Division Leukocyte Degranulation Insulin Secretion Ventricular System Development Myelination In Peripheral Nervous System Organ Development Membrane Organization
Tagcloud ?		adapter affinities arise asymmetric bind bond contain diverse division domain gp gppy helical hydrogen ldnpay library lnx modes motif nak nmr npxy peptide phosphotyrosine ptb reveals sheet turn y	4a act1 apparatus carrying compete differing efficiencies enter entry exponential hsp12 hsp26 idea inert lacz leaders mrnas pgk1 polysome pyk1 raising rp29 saccharomyces starvation stationary thi4 translatabilities translated translational
Tagcloud (Difference) ?		adapter affinities arise asymmetric bind bond contain diverse division domain gp gppy helical hydrogen ldnpay library lnx modes motif nak nmr npxy peptide phosphotyrosine ptb reveals sheet turn y	4a act1 apparatus carrying compete differing efficiencies enter entry exponential hsp12 hsp26 idea inert lacz leaders mrnas pgk1 polysome pyk1 raising rp29 saccharomyces starvation stationary thi4 translatabilities translated translational
Tagcloud (Intersection) ?