NUMB and ITGB2

Number of citations of the paper that reports this interaction (PMID 12606711)
66

Data Source:
HPRD (in vitro)

		NUMB	ITGB2
Gene Name		numb homolog (Drosophila)	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Apical Part Of Cell	Plasma Membrane Integrin Complex Cell Surface Membrane Vesicle Integrin AlphaL-beta2 Complex Receptor Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding	Glycoprotein Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Protein Complex Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Notch Signaling Pathway Axon Guidance Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Positive Regulation Of Polarized Epithelial Cell Differentiation Adherens Junction Organization Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Neurogenesis Lung Epithelial Cell Differentiation Negative Regulation Of Protein Localization To Plasma Membrane	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Aging Blood Coagulation Regulation Of Cell Shape Natural Killer Cell Activation Extracellular Matrix Organization Neutrophil Chemotaxis Heterotypic Cell-cell Adhesion Toll-like Receptor 4 Signaling Pathway Endodermal Cell Differentiation Receptor Clustering Endothelial Cell Migration Innate Immune Response Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Activated T Cell Proliferation Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH L1CAM interactions Recycling pathway of L1 Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Degradation of GLI1 by the proteasome Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer	Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System Innate Immune System
Drugs			Simvastatin
Diseases
GWAS		Bipolar disorder (mood-incongruent) ( 23092984) Coronary artery calcification ( 17903303)
Protein-Protein Interactions		24 interactors: AP2A1 AP2A2 APP DPYSL2 EGFR EPS15 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MDM2 NOTCH1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ RPL3 SIAH1	41 interactors: CD14 CD226 CD82 COPS3 COPS5 CYTH1 CYTH2 DAB1 DOK1 ESM1 FCER2 FHL2 FUT4 GNB2L1 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 NOTCH2NL NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RANBP9 RDX SYK TLN1 VNN2
Entrez ID		8650	3689
HPRD ID		04767	02506
Ensembl ID		ENSG00000133961	ENSG00000160255
Uniprot IDs		P49757	A8MYE6 P05107
PDB IDs			1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Blood Coagulation Hemostasis Response To Growth Factor Wound Healing Platelet Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Activation Response To Wounding Regulation Of Immune System Process Regulation Of Body Fluid Levels Immune System Process Cell Surface Receptor Signaling Pathway Response To External Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Locomotion Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Signaling Regulation Of Phospholipase Activity Chemotaxis Positive Regulation Of Lipase Activity Neuron Projection Morphogenesis Signal Transduction Cellular Response To Organic Substance Signaling Response To Organic Substance Axonogenesis Defense Response Activation Of Phospholipase C Activity Cell Communication Cellular Response To Stimulus Axon Development Neuron Projection Development Innate Immune Response Negative Regulation Of Signal Transduction Axon Guidance Positive Regulation Of Phospholipase C Activity Regulation Of Cellular Amino Acid Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Part Morphogenesis Negative Regulation Of Signaling Response To Stimulus	Blood Coagulation Hemostasis Platelet Activation Cell Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell Adhesion Regulation Of Immune System Process Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Single Organismal Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Signal Transduction Defense Response Signal Transduction Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Glial Cell Apoptotic Process Movement Of Cell Or Subcellular Component Locomotion Regulation Of Signaling Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To External Stimulus Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Immune Response Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Immune System Process Positive Regulation Of Phosphorylation Leukocyte Activation Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Activation Of Phospholipase C Activity
Tagcloud ?		adapter affinities arise asymmetric bind bond contain diverse division domain gp gppy helical hydrogen ldnpay library lnx modes motif nak nmr npxy peptide phosphotyrosine ptb reveals sheet turn y	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Difference) ?		adapter affinities arise asymmetric bind bond contain diverse division domain gp gppy helical hydrogen ldnpay library lnx modes motif nak nmr npxy peptide phosphotyrosine ptb reveals sheet turn y	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Intersection) ?