KAT2B and YY1

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (enzymatic study, proximity labelling technology)

		KAT2B	YY1
Description		lysine acetyltransferase 2B	YY1 transcription factor
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex SAGA Complex Kinetochore Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton A Band I Band Protein-containing Complex Actomyosin Mitotic Spindle ATAC Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromatin Silencing Complex Nuclear Matrix Ino80 Complex PcG Protein Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Diamine N-acetyltransferase Activity Histone Acetyltransferase Activity L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Enzyme Activator Activity Histone H3 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein Kinase Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Histone H3K9 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity DNA-binding Transcription Factor Binding	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding SMAD Binding Metal Ion Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Gluconeogenesis Regulation Of DNA Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Heart Development Memory Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Vasodilation Regulation Of RNA Splicing Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Gluconeogenesis Positive Regulation Of Fatty Acid Biosynthetic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Negative Regulation Of Centriole Replication Positive Regulation Of Lipid Biosynthetic Process Rhythmic Process Regulation Of Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Limb Development Regulation Of Small Molecule Metabolic Process Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Ferroptosis Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of RRNA Processing	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Localization DNA Damage Response Spermatogenesis Anterior/posterior Pattern Specification Response To UV-C Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Hemopoiesis Cell Differentiation B Cell Differentiation Negative Regulation Of Interferon-beta Production Regulation Of Chromosome Organization Cellular Response To UV Response To Prostaglandin F Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Camera-type Eye Morphogenesis Chromosome Organization Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Interleukin-1 Immunoglobulin Heavy Chain V-D-J Recombination Negative Regulation Of MiRNA Transcription Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Physiological factors Metalloprotease DUBs RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression Regulation of FOXO transcriptional activity by acetylation Formation of WDR5-containing histone-modifying complexes Formation of paraxial mesoderm	Activation of anterior HOX genes in hindbrain development during early embryogenesis UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression
Drugs		Coenzyme A (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Diseases
GWAS		Drug abuse ( 26202629) High light scatter reticulocyte count ( 32888494) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Optic disc size ( 31809533) Post-traumatic stress disorder ( 24677629) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Systolic blood pressure ( 30578418 30224653)	Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Pulse pressure ( 30224653)
Interacting Genes		128 interacting genes: ACTN1 ACTN2 AKT1 AR ARHGDIA ATF4 ATXN3 BMAL1 BRCA2 CCNA2 CCND1 CCNT1 CDC25B CDCA4 CDK2 CDKN1B CDT1 CEBPB CEP250 CIITA CLOCK CREBBP CTBP1 CTNNB1 CUX1 DACH2 DEK EP300 ESRRA ETV1 EZH2 GATAD2A GATAD2B H1-1 H1-5 H2AC20 H2AC4 H2BC21 H2BC3 H3-3A H3-4 H3C1 H3C14 H4C1 H4C16 HIPK2 HMGA1 HMGA2 HMGN2 HNF1A HNRNPU HOXB9 HSD11B2 HTT ING1 IRF1 IRF2 IRF7 JDP2 KLF10 KLF13 KLF2 LIN28B MAPK14 MAPRE1 MDM2 MECOM MYC MYOD1 N4BP3 NCOA1 NCOA3 NCOA4 NFATC1 NFE2 NFE4 NOTCH1 NOTCH3 NPAS2 NR1H3 NR4A1 NRIP1 ONECUT1 PARP1 PDK1 PGR PLAGL1 PNMA1 POLR2A PTF1A RAB11A RARA RB1 RBM8A RBPJ RELA RPA1 RPS6KB1 RPS6KB2 SAT2 SATB1 SERBP1 SERPINH1 SERTAD1 SERTAD2 SIRT2 SIRT7 SMAD1 SMAD2 SMAD3 SNCA SP1 SRCAP TACC2 TAL1 TCF3 TMF1 TP53 TP63 TP73 TRIM14 TTF1 TWIST1 UBE2D1 UBE2D2 UBE2D3 XRCC6 YY1	98 interacting genes: ALOXE3 APP ATF2 ATF6 ATF7 AURKA BAP1 BRCA1 CDKN2A CEBPA CEP76 CREB1 CREBBP CRKL CYSRT1 DNMT3L E2F2 E2F3 EED EP300 ESM1 FHL2 FKBP1A FKBP3 FOXP1 FOXP2 FOXP4 GFER GMCL1 GRN GTF2I HDAC2 HDAC3 HMGB1 HNF1B HOXA11 IL10 ITCH KAT2B KRTAP1-3 KRTAP1-5 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP4-5 KRTAP5-6 KRTAP9-3 KRTAP9-8 MDFI MED20 MTA2 MYC NEDD4L NFIC NFIX NFKB1 NOTCH1 NPM1 NR1H2 PIAS4 PLEKHF2 PPIA PSMD9 RAF1 RYBP SAP30 SF3A2 SKP2 SLC39A7 SMAD1 SMAD2 SMAD3 SMURF2 SP1 SPRY1 SREBF1 TESK1 TFCP2 TP53 TRIM42 TWIST1 UBE2I UHRF2 USP21 USP7 VWC2 XAGE1A XAGE1B YAF2 ZNF232 ZNF85 ZRANB2
Entrez ID		8850	7528
HPRD ID		06780	02482
Ensembl ID		ENSG00000114166	ENSG00000100811
Uniprot IDs		Q92831	P25490
PDB IDs		1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX 6J3O	1UBD 1ZNM 4C5I
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Macromolecule Metabolic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Chromatin Positive Regulation Of Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Negative Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Transcription Regulator Complex DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Regulation Of Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Protein-containing Complex DNA-binding Transcription Factor Binding Sequence-specific DNA Binding Regulation Of Developmental Process Intracellular Signal Transduction	Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intermediate Filament Chromatin Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Keratin Filament Epigenetic Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription By RNA Polymerase II Negative Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Identical Protein Binding Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Transcription Regulator Complex Chromatin Remodeling
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