KAT2B and DEK

Number of citations of the paper that reports this interaction (PMID 15987677)
23

Data Source:
BioGRID (enzymatic study)

		KAT2B	DEK
Gene Name		K(lysine) acetyltransferase 2B	DEK proto-oncogene
Image
Gene Ontology Annotations	Cellular Component	PCAF Complex Kinetochore Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex A Band I Band Actomyosin	Nucleus Contractile Fiber
	Molecular Function	Transcription Cofactor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Protein Kinase Binding Protein Complex Binding Histone Deacetylase Binding	DNA Binding Histone Binding Poly(A) RNA Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase II Promoter Protein Acetylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Gene Expression Regulation Of Protein ADP-ribosylation Viral Process N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Cellular Response To Insulin Stimulus Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H3-K9 Acetylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Chromatin Modification Viral Genome Replication Regulation Of Double-strand Break Repair Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HATs acetylate histones Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Chromatin organization RNA Polymerase I Transcription Signaling by NOTCH Notch-HLH transcription pathway NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer YAP1- and WWTR1 (TAZ)-stimulated gene expression Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions		116 interactors: ACTN1 ACTN2 AKT1 AR ARNTL ATF4 ATXN3 BRCA2 CCNA2 CCND1 CCNT1 CDC25B CDCA4 CDK2 CDKN1B CDT1 CEBPB CEP250 CIITA CLOCK CNTN2 CREBBP CTBP1 CTNNB1 CUX1 DACH2 DEK EP300 ESRRA ETV1 GATAD2A GATAD2B H3F3A HIPK2 HIST1H1A HIST1H1B HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST2H3C HIST3H3 HIST4H4 HMGA1 HMGN2 HNF1A HNRNPU HSD11B2 HTT ING1 IRF1 IRF2 IRF7 JDP2 KLF10 KLF13 KLF2 MAPK14 MAPRE1 MDM2 MECOM MYC MYOD1 NCOA1 NCOA3 NCOA4 NFATC1 NFE2 NFE4 NOTCH1 NOTCH3 NPAS2 NR1H3 NR4A1 NRIP1 ONECUT1 PARP1 PDK1 PGR PLAGL1 PNMA1 POLR2A PTF1A RAB11A RARA RB1 RBPJ RELA RPS6KB1 RPS6KB2 SAT2 SATB1 SERBP1 SERTAD1 SERTAD2 SIRT2 SMAD1 SMAD2 SMAD3 SRC SRCAP TACC2 TAL1 TCF3 TMF1 TP53 TP63 TP73 TTF1 TWIST1 UBE2D1 UBE2D3 XRCC6 YY1	10 interactors: AP2A1 CREBBP CSNK2A1 EP300 HIST3H3 HLA-A KAT2B SRRM1 TFAP2A ZIK1
Entrez ID		8850	7913
HPRD ID		06780	00503
Ensembl ID		ENSG00000114166	ENSG00000124795
Uniprot IDs		Q92831	B4DFG0 P35659
PDB IDs		1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3	1Q1V 2JX3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Chromosome Organization Chromatin Organization Response To Stress Regulation Of Cell Differentiation Response To Organic Substance Regulation Of Cell Proliferation Regulation Of Cellular Process Regulation Of Cell Cycle Cellular Response To Organic Substance Organelle Organization System Development Developmental Process Cellular Metabolic Process Anatomical Structure Development	N-terminal Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation N-terminal Protein Amino Acid Modification Viral Process Rhythmic Process Transcription, DNA-templated RNA Biosynthetic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Notch Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Defense Response To Virus By Virus Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Response To Heat Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Macromolecule Biosynthetic Process Negative Regulation Of ERBB Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Nitrogen Compound Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Transcription From RNA Polymerase II Promoter Cellular Response To Heat Positive Regulation Of Cytokine Production Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Histone H2B Acetylation Optic Cup Structural Organization Positive Regulation Of Type I Interferon Production Histone Modification Regulation Of ERBB Signaling Pathway Regulation Of Defense Response To Virus Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Oculomotor Nerve Formation Positive Regulation Of Memory T Cell Activation Optic Vesicle Morphogenesis
Tagcloud ?		accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1	abnormality basophils biomolecular chimaeric chromosomal cml continuously doubled eosinophils fkh granulocyte heterogenous leukaemia leukaemogenesis morphologies multilineage myelocytic myeloid myelomonocytic oft p23 permanent ph1 philadelphia pluripotent proliferating q34 rarely transcript
Tagcloud (Difference) ?		accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat3a kat3b kat5 multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1	abnormality basophils biomolecular chimaeric chromosomal cml continuously doubled eosinophils fkh granulocyte heterogenous leukaemia leukaemogenesis morphologies myelocytic myeloid myelomonocytic oft p23 permanent ph1 philadelphia pluripotent proliferating q34 rarely transcript
Tagcloud (Intersection) ?		multilineage