KAT2B and SIRT2

Number of citations of the paper that reports this interaction (PubMedID 12887892)
0

Data Source:
HPRD (in vivo)

		KAT2B	SIRT2
Description		lysine acetyltransferase 2B	sirtuin 2
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex SAGA Complex Kinetochore Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton A Band I Band Protein-containing Complex Actomyosin Mitotic Spindle ATAC Complex	Chromosome, Telomeric Region Heterochromatin Nucleus Chromatin Silencing Complex Chromosome Nucleolus Cytoplasm Mitochondrion Centrosome Centriole Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Membrane Growth Cone Midbody Paranodal Junction Paranode Region Of Axon Cell Projection Perikaryon Myelin Sheath Lateral Loop Schmidt-Lanterman Incisure Juxtaparanode Region Of Axon Perinuclear Region Of Cytoplasm Mitotic Spindle Meiotic Spindle Glial Cell Projection
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Diamine N-acetyltransferase Activity Histone Acetyltransferase Activity L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Enzyme Activator Activity Histone H3 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein Kinase Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Histone H3K9 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity DNA-binding Transcription Factor Binding	Chromatin Binding NAD+ Poly-ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Transferase Activity Histone Deacetylase Activity, NAD-dependent Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Histone Acetyltransferase Binding Histone Deacetylase Binding Tubulin Deacetylase Activity Ubiquitin Binding Metal Ion Binding Histone H4K16 Deacetylase Activity, NAD-dependent NAD Binding NAD+ Binding DNA-binding Transcription Factor Binding NAD-dependent Protein Demyristoylase Activity NAD-dependent Protein Depalmitoylase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Gluconeogenesis Regulation Of DNA Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Heart Development Memory Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Vasodilation Regulation Of RNA Splicing Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Gluconeogenesis Positive Regulation Of Fatty Acid Biosynthetic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Negative Regulation Of Centriole Replication Positive Regulation Of Lipid Biosynthetic Process Rhythmic Process Regulation Of Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Limb Development Regulation Of Small Molecule Metabolic Process Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Ferroptosis Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of RRNA Processing	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Immune System Process Chromatin Organization Protein Deacetylation Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Autophagy Mitotic Nuclear Membrane Reassembly Regulation Of Exit From Mitosis Nervous System Development Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Skeletal Muscle Satellite Cell Differentiation Lipid Catabolic Process Substantia Nigra Development Myelination In Peripheral Nervous System Cell Differentiation Heterochromatin Formation Subtelomeric Heterochromatin Formation Regulation Of Myelination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Peptidyl-lysine Deacetylation Epigenetic Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Regulation Of Phosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Post-translational Protein Modification NLRP3 Inflammasome Complex Assembly Innate Immune Response Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Biosynthetic Process Negative Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cell Division Meiotic Cell Cycle Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Caloric Restriction Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Hypoxia Cellular Response To Epinephrine Stimulus Tubulin Deacetylation Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Oocyte Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Physiological factors Metalloprotease DUBs RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression Regulation of FOXO transcriptional activity by acetylation Formation of WDR5-containing histone-modifying complexes Formation of paraxial mesoderm	Initiation of Nuclear Envelope (NE) Reformation
Drugs		Coenzyme A (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE N-(3-AMINOPROPYL)-2-NITROBENZENAMINE	Cambinol
Diseases
GWAS		Drug abuse ( 26202629) High light scatter reticulocyte count ( 32888494) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Optic disc size ( 31809533) Post-traumatic stress disorder ( 24677629) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Systolic blood pressure ( 30578418 30224653)
Interacting Genes		128 interacting genes: ACTN1 ACTN2 AKT1 AR ARHGDIA ATF4 ATXN3 BMAL1 BRCA2 CCNA2 CCND1 CCNT1 CDC25B CDCA4 CDK2 CDKN1B CDT1 CEBPB CEP250 CIITA CLOCK CREBBP CTBP1 CTNNB1 CUX1 DACH2 DEK EP300 ESRRA ETV1 EZH2 GATAD2A GATAD2B H1-1 H1-5 H2AC20 H2AC4 H2BC21 H2BC3 H3-3A H3-4 H3C1 H3C14 H4C1 H4C16 HIPK2 HMGA1 HMGA2 HMGN2 HNF1A HNRNPU HOXB9 HSD11B2 HTT ING1 IRF1 IRF2 IRF7 JDP2 KLF10 KLF13 KLF2 LIN28B MAPK14 MAPRE1 MDM2 MECOM MYC MYOD1 N4BP3 NCOA1 NCOA3 NCOA4 NFATC1 NFE2 NFE4 NOTCH1 NOTCH3 NPAS2 NR1H3 NR4A1 NRIP1 ONECUT1 PARP1 PDK1 PGR PLAGL1 PNMA1 POLR2A PTF1A RAB11A RARA RB1 RBM8A RBPJ RELA RPA1 RPS6KB1 RPS6KB2 SAT2 SATB1 SERBP1 SERPINH1 SERTAD1 SERTAD2 SIRT2 SIRT7 SMAD1 SMAD2 SMAD3 SNCA SP1 SRCAP TACC2 TAL1 TCF3 TMF1 TP53 TP63 TP73 TRIM14 TTF1 TWIST1 UBE2D1 UBE2D2 UBE2D3 XRCC6 YY1	23 interacting genes: ARHGDIA ATRIP CDC14B CDC20 CDK2 EP300 FZR1 H3C1 HDAC6 HIF1A HOXA10 KAT2A KAT2B MCL1 MDM2 MORC2 OXTR PHGDH PLA2G4A RAD51 SP140 TUBA4A XPO1
Entrez ID		8850	22933
HPRD ID		06780	10377
Ensembl ID		ENSG00000114166	ENSG00000068903
Uniprot IDs		Q92831	A0A0A0MRF5 Q8IXJ6
PDB IDs		1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX 6J3O	1J8F 3ZGO 3ZGV 4L3O 4R8M 4RMG 4RMH 4RMI 4RMJ 4X3O 4X3P 4Y6L 4Y6O 4Y6Q 5D7O 5D7P 5D7Q 5DY4 5DY5 5FYQ 5G4C 5MAR 5MAT 5Y0Z 5Y5N 5YQL 5YQM 5YQN 5YQO 6L65 6L66 6L71 6L72 6NR0 6QCN 7BOS 7BOT 8OWZ 8PY3 8QOO 8QT0 8QT1 8QT2 8QT3 8QT4 8QT8 8QTU 8TGP 8XE7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Macromolecule Metabolic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Chromatin Positive Regulation Of Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Negative Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Transcription Regulator Complex DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Regulation Of Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Protein-containing Complex DNA-binding Transcription Factor Binding Sequence-specific DNA Binding Regulation Of Developmental Process Intracellular Signal Transduction	Regulation Of Cell Cycle Process Histone Deacetylase Binding Negative Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Cellular Response To Stress Negative Regulation Of Cell Cycle Internal Protein Amino Acid Acetylation Nucleoplasm Protein-containing Complex Regulation Of Metabolic Process DNA Damage Response Regulation Of Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Peptidyl-lysine Acetylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Histone H3K9 Acetyltransferase Activity Acetyltransferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Histone Acetyltransferase Complex Regulation Of Cellular Response To Stress Protein-lysine-acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis DNA Damage Checkpoint Signaling Histone Acetyltransferase Activity Nucleus Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cell Cycle Phase Transition Protein Acetylation Chromatin Remodeling Small Molecule Biosynthetic Process L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Monocarboxylic Acid Metabolic Process Epigenetic Regulation Of Gene Expression Cytosol Negative Regulation Of Centriole Replication Regulation Of Centrosome Duplication Intracellular Signal Transduction Response To Stress Gluconeogenesis Regulation Of Gluconeogenesis
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