KAT2B and H3-4

Number of citations of the paper that reports this interaction (PubMedID 8684459)
0

Data Source:
BioGRID (enzymatic study)

		KAT2B	H3-4
Description		lysine acetyltransferase 2B	H3.4 histone, cluster member
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex SAGA Complex Kinetochore Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton A Band I Band Protein-containing Complex Actomyosin Mitotic Spindle ATAC Complex	Chromosome, Telomeric Region Nucleosome Heterochromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Diamine N-acetyltransferase Activity Histone Acetyltransferase Activity L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Enzyme Activator Activity Histone H3 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein Kinase Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Histone H3K9 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity DNA-binding Transcription Factor Binding	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Gluconeogenesis Regulation Of DNA Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Heart Development Memory Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Vasodilation Regulation Of RNA Splicing Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Gluconeogenesis Positive Regulation Of Fatty Acid Biosynthetic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Negative Regulation Of Centriole Replication Positive Regulation Of Lipid Biosynthetic Process Rhythmic Process Regulation Of Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Limb Development Regulation Of Small Molecule Metabolic Process Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Ferroptosis Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of RRNA Processing	Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Regulation Of Cell Differentiation
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Physiological factors Metalloprotease DUBs RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression Regulation of FOXO transcriptional activity by acetylation Formation of WDR5-containing histone-modifying complexes Formation of paraxial mesoderm	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Meiotic recombination Inhibition of DNA recombination at telomere
Drugs		Coenzyme A (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Diseases
GWAS		Drug abuse ( 26202629) High light scatter reticulocyte count ( 32888494) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Optic disc size ( 31809533) Post-traumatic stress disorder ( 24677629) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Systolic blood pressure ( 30578418 30224653)
Interacting Genes		128 interacting genes: ACTN1 ACTN2 AKT1 AR ARHGDIA ATF4 ATXN3 BMAL1 BRCA2 CCNA2 CCND1 CCNT1 CDC25B CDCA4 CDK2 CDKN1B CDT1 CEBPB CEP250 CIITA CLOCK CREBBP CTBP1 CTNNB1 CUX1 DACH2 DEK EP300 ESRRA ETV1 EZH2 GATAD2A GATAD2B H1-1 H1-5 H2AC20 H2AC4 H2BC21 H2BC3 H3-3A H3-4 H3C1 H3C14 H4C1 H4C16 HIPK2 HMGA1 HMGA2 HMGN2 HNF1A HNRNPU HOXB9 HSD11B2 HTT ING1 IRF1 IRF2 IRF7 JDP2 KLF10 KLF13 KLF2 LIN28B MAPK14 MAPRE1 MDM2 MECOM MYC MYOD1 N4BP3 NCOA1 NCOA3 NCOA4 NFATC1 NFE2 NFE4 NOTCH1 NOTCH3 NPAS2 NR1H3 NR4A1 NRIP1 ONECUT1 PARP1 PDK1 PGR PLAGL1 PNMA1 POLR2A PTF1A RAB11A RARA RB1 RBM8A RBPJ RELA RPA1 RPS6KB1 RPS6KB2 SAT2 SATB1 SERBP1 SERPINH1 SERTAD1 SERTAD2 SIRT2 SIRT7 SMAD1 SMAD2 SMAD3 SNCA SP1 SRCAP TACC2 TAL1 TCF3 TMF1 TP53 TP63 TP73 TRIM14 TTF1 TWIST1 UBE2D1 UBE2D2 UBE2D3 XRCC6 YY1	195 interacting genes: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BACC1 BIRC5 BMI1 BPTF BRD7 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK COPRS CREBBP CTBP1 CTBP2 DCAF1 DEK DNMT1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EMSY EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPL HNRNPR HPF1 ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM1B KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2C KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 MYB NAP1L4 NASP NBN NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 NSD2 ORC2 ORC3 ORC4 ORC5 PARP1 PARP2 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PHRF1 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRMT5 PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RIPPLY1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SGF29 SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TCF19 TDRD3 TNPO1 TRPM7 UHRF1 WDR5 ZMYM4 ZMYND11 ZNF217 ZNF516
Entrez ID		8850	8290
HPRD ID		06780	04156
Ensembl ID		ENSG00000114166	ENSG00000168148
Uniprot IDs		Q92831	Q16695
PDB IDs		1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX 6J3O	2V1D 2YBP 2YBS 3A6N 3T6R 4V2V 4V2W 6OIE 6WAT 6WAU 8VMI 8Z50
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Macromolecule Metabolic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Chromatin Positive Regulation Of Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Negative Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Transcription Regulator Complex DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Regulation Of Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Protein-containing Complex DNA-binding Transcription Factor Binding Sequence-specific DNA Binding Regulation Of Developmental Process Intracellular Signal Transduction	Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Transcription Factor TFIID Complex Chromosome Protein-DNA Complex Assembly Nucleic Acid Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFTC Complex Negative Regulation Of Gene Expression, Epigenetic SAGA Complex MRNA Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress RNA Polymerase II Preinitiation Complex Assembly Transcription Coactivator Activity Chromosome, Telomeric Region
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