BAP1 and YY1

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (proximity labelling technology, pull down, pull down)

		BAP1	YY1
Description		BRCA1 associated deubiquitinase 1	YY1 transcription factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol PR-DUB Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromatin Silencing Complex Nuclear Matrix Ino80 Complex PcG Protein Complex
	Molecular Function	Chromatin Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Chromatin DNA Binding Histone H2A Deubiquitinase Activity	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding SMAD Binding Metal Ion Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Cell Growth In Utero Embryonic Development Tissue Homeostasis Thrombocyte Differentiation Chromatin Organization Proteolysis Ubiquitin-dependent Protein Catabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Protein Deubiquitination Cell Differentiation Erythrocyte Differentiation Neutrophil Differentiation Granulocyte Differentiation Heterochromatin Formation Myeloid Cell Apoptotic Process Monoubiquitinated Protein Deubiquitination Common Myeloid Progenitor Cell Proliferation Protein Modification Process Platelet Morphogenesis Erythrocyte Maturation Nucleate Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Inflammatory Response Regulation Of Cell Cycle Hematopoietic Stem Cell Homeostasis Macrophage Homeostasis Neuron Cellular Homeostasis Leukocyte Proliferation Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Localization DNA Damage Response Spermatogenesis Anterior/posterior Pattern Specification Response To UV-C Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Hemopoiesis Cell Differentiation B Cell Differentiation Negative Regulation Of Interferon-beta Production Regulation Of Chromosome Organization Cellular Response To UV Response To Prostaglandin F Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Camera-type Eye Morphogenesis Chromosome Organization Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Interleukin-1 Immunoglobulin Heavy Chain V-D-J Recombination Negative Regulation Of MiRNA Transcription Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Activation of anterior HOX genes in hindbrain development during early embryogenesis UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Pulse pressure ( 30224653)
Interacting Genes		30 interacting genes: ASXL1 BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 H2BC3 HIF1A IGF1R ITPR3 LINC00598 MAP3K1 NBN PTPRJ RB1CC1 STK11 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1	98 interacting genes: ALOXE3 APP ATF2 ATF6 ATF7 AURKA BAP1 BRCA1 CDKN2A CEBPA CEP76 CREB1 CREBBP CRKL CYSRT1 DNMT3L E2F2 E2F3 EED EP300 ESM1 FHL2 FKBP1A FKBP3 FOXP1 FOXP2 FOXP4 GFER GMCL1 GRN GTF2I HDAC2 HDAC3 HMGB1 HNF1B HOXA11 IL10 ITCH KAT2B KRTAP1-3 KRTAP1-5 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP4-5 KRTAP5-6 KRTAP9-3 KRTAP9-8 MDFI MED20 MTA2 MYC NEDD4L NFIC NFIX NFKB1 NOTCH1 NPM1 NR1H2 PIAS4 PLEKHF2 PPIA PSMD9 RAF1 RYBP SAP30 SF3A2 SKP2 SLC39A7 SMAD1 SMAD2 SMAD3 SMURF2 SP1 SPRY1 SREBF1 TESK1 TFCP2 TP53 TRIM42 TWIST1 UBE2I UHRF2 USP21 USP7 VWC2 XAGE1A XAGE1B YAF2 ZNF232 ZNF85 ZRANB2
Entrez ID		8314	7528
HPRD ID		04366	02482
Ensembl ID		ENSG00000163930	ENSG00000100811
Uniprot IDs		F8W6N3 Q92560	P25490
PDB IDs		7VPW 8H1T 8SVF	1UBD 1ZNM 4C5I
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Protein Modification Process Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Nucleus Protein Metabolic Process Telomere Maintenance Via Telomere Trimming Nuclear Body Cysteine-type Peptidase Activity Heterochromatin Formation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nucleoplasm Epigenetic Regulation Of Gene Expression Macromolecule Metabolic Process Response To Radiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Negative Regulation Of MiRNA Transcription Structural Constituent Of Chromatin Cysteine-type Deubiquitinase Activity Apoptotic Signaling Pathway Response To Light Stimulus Chromosome Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Deubiquitination Regulation Of Cell Communication Regulation Of Signaling Telomere Maintenance Negative Regulation Of Metabolic Process BRCA1-C Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Localization To Chromosome Negative Regulation Of Growth Double-strand Break Repair Protein Modification By Small Protein Removal Nucleosome DNA Damage Response Telomere Organization Ubiquitin-modified Histone Reader Activity Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Repair Recombinational Repair Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction	Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intermediate Filament Chromatin Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Keratin Filament Epigenetic Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription By RNA Polymerase II Negative Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Identical Protein Binding Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Transcription Regulator Complex Chromatin Remodeling
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