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BAP1 and HIST2H2AA3
Number of citations of the paper that reports this interaction (PMID
24703950
)
0
Data Source:
BioGRID
(enzymatic study)
BAP1
HIST2H2AA3
Gene Name
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
histone cluster 2, H2aa3
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
PR-DUB Complex
Nucleosome
Nucleus
Extracellular Vesicular Exosome
Molecular Function
Chromatin Binding
Ubiquitin-specific Protease Activity
Protein Binding
Peptidase Activity
Molecular_function
DNA Binding
Protein Heterodimerization Activity
Biological Process
Regulation Of Cell Growth
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cell Proliferation
Protein Deubiquitination
Monoubiquitinated Protein Deubiquitination
Monoubiquitinated Histone H2A Deubiquitination
Regulation Of Cell Cycle
Protein K48-linked Deubiquitination
Biological_process
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Bipolar disorder (
21926972
)
Protein-Protein Interactions
10 interactors:
BRCA1
HIST2H2AA3
HIST2H2AC
TRIM63
UBE2O
USP15
USP2
USP21
USP28
YY1
16 interactors:
APP
BAP1
BMI1
DNAJC2
IL33
MSL2
NOC2L
PARP1
PRMT6
RCC1
RNF2
RNF20
TBL1X
UBE2H
USP16
USP21
Entrez ID
8314
8337
HPRD ID
04366
08851
Ensembl ID
ENSG00000163930
Uniprot IDs
Q92560
Q6FI13
PDB IDs
Enriched GO Terms of Interacting Partners
?
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Protein Deubiquitination
Protein Modification By Small Protein Removal
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Regulation Of Protein Catabolic Process
Response To Radiation
Histone Deubiquitination
Response To Abiotic Stimulus
Cellular Protein Modification Process
Regulation Of Proteolysis
Proteolysis
Cellular Response To UV
Response To Light Stimulus
Catabolic Process
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Histone H4-K16 Acetylation
Cellular Protein Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Light Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Histone H3-K9 Acetylation
Histone H2B Conserved C-terminal Lysine Deubiquitination
Response To Prostaglandin F
Signal Transduction By P53 Class Mediator
Regulation Of Protein Metabolic Process
Positive Regulation Of Histone H4 Acetylation
Negative Regulation Of Histone H3-K4 Methylation
Response To UV
Protein Ubiquitination
Cellular Response To Radiation
DNA Repair
Response To Ionizing Radiation
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Protein Modification By Small Protein Conjugation
Double-strand Break Repair
DNA Damage Checkpoint
Cellular Response To Indole-3-methanol
Protein Metabolic Process
Protein Polyubiquitination
Negative Regulation Of Centriole Replication
Skeletal Muscle Atrophy
Chromosome Organization
Chromatin Organization
Chromatin Modification
Histone Modification
Organelle Organization
Histone Ubiquitination
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Cellular Protein Modification Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Cellular Protein Metabolic Process
Regulation Of RNA Biosynthetic Process
Gene Expression
Regulation Of RNA Metabolic Process
Histone Deubiquitination
Histone Monoubiquitination
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Histone H2A-K119 Monoubiquitination
Protein Metabolic Process
Protein Catabolic Process
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Monoubiquitinated Histone H2A Deubiquitination
Positive Regulation Of Gene Expression
Macromolecule Biosynthetic Process
Protein Monoubiquitination
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Gene Expression
Cellular Macromolecule Catabolic Process
Tagcloud
?
1000x
abstracted
arid1a
cca
cdkn2a
cholangiocarcinoma
entities
extrahepatic
fbxw7
fgfr
gas
hiseq
hotspot
idh1
illumina
indolent
intrahepatic
introns
kras
mcl1
ngs
pbrm1
pgm
presentations
radiologic
sequencer
smad4
targetable
worse
Tagcloud (Difference)
?
1000x
abstracted
arid1a
cca
cdkn2a
cholangiocarcinoma
entities
extrahepatic
fbxw7
fgfr
gas
hiseq
hotspot
idh1
illumina
indolent
intrahepatic
introns
kras
mcl1
ngs
pbrm1
pgm
presentations
radiologic
sequencer
smad4
targetable
worse
Tagcloud (Intersection)
?