BAP1 and USP2

Number of citations of the paper that reports this interaction (PubMedID 24703950)
0

Data Source:
BioGRID (enzymatic study)

		BAP1	USP2
Description		BRCA1 associated deubiquitinase 1	ubiquitin specific peptidase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol PR-DUB Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Chromatin DNA Binding Histone H2A Deubiquitinase Activity	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Cell Growth In Utero Embryonic Development Tissue Homeostasis Thrombocyte Differentiation Chromatin Organization Proteolysis Ubiquitin-dependent Protein Catabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Protein Deubiquitination Cell Differentiation Erythrocyte Differentiation Neutrophil Differentiation Granulocyte Differentiation Heterochromatin Formation Myeloid Cell Apoptotic Process Monoubiquitinated Protein Deubiquitination Common Myeloid Progenitor Cell Proliferation Protein Modification Process Platelet Morphogenesis Erythrocyte Maturation Nucleate Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Inflammatory Response Regulation Of Cell Cycle Hematopoietic Stem Cell Homeostasis Macrophage Homeostasis Neuron Cellular Homeostasis Leukocyte Proliferation Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Rhythmic Process Circadian Behavior Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator
Pathways		UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Refractive error ( 32231278) Serum uric acid levels ( 30993211) Urate levels ( 23263486 31578528 31985003)
Interacting Genes		30 interacting genes: ASXL1 BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 H2BC3 HIF1A IGF1R ITPR3 LINC00598 MAP3K1 NBN PTPRJ RB1CC1 STK11 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1	178 interacting genes: ABI2 ACTN1 ACTN2 ACTN3 APP AR ASPG ATG14 ATN1 AURKA BAP1 BCAR1 BCL2L2-PABPN1 BEGAIN BEND5 BICD2 BIRC7 BRCA1 CADPS CALCOCO2 CARD9 CBLC CCDC136 CCDC57 CCDC85B CCDC88B CDC34 CEP63 CEP70 CRACR2A CRACR2B CRY1 DCAF1 DDI1 DEPDC5 DISC1 DSCR4 DTX3 DUSP21 DYDC1 E2F4 EFHC2 EIF4ENIF1 ENPP1 ERBB2 EXOC5 EXOSC8 FANCD2 FBXW7 G3BP1 GEMIN4 GOLGA2 GOLGA6A GOLGA6L9 GPRASP3 GRB7 GRIPAP1 H2AC20 H2AC4 H2BC3 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IKZF3 IL1RL2 INTS11 JAKMIP1 JRK KAZN KIFC3 KRT15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT40 LHX3 LHX4 LMNA LMNB2 LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MID2 MLKL MNAT1 MORN5 MRPL28 MTUS2 MYC NAB2 NDEL1 NEFL NFKB2 NOTCH1 NR3C1 OIP5 OPTN ORC3 ORC5 PALB2 PCGF6 PEX5 PIBF1 PICK1 PIK3R3 PLA2G2A PLEKHG4 PML PNMA1 POU2AF1 PRDM14 PRR5L RABEP1 RAD18 RBCK1 RFX6 RNF125 RNF126 RNF144B RNF149 RNF166 RUNDC3A S100A10 SH2B2 SLC2A1 SMAD7 SNCA SORBS3 SPAG8 SPDYE4 STAT5B TAX1BP1 TEKT4 TFIP11 TGFBR1 TLE5 TNFAIP2 TRAF1 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM50 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 TRIP6 UBC UBE2S UBOX5 USHBP1 USP15 USP21 USP54 VCAM1 VPS28 VPS52 ZAP70 ZBED1 ZIM2 ZRANB1
Entrez ID		8314	9099
HPRD ID		04366	05287
Ensembl ID		ENSG00000163930	ENSG00000036672
Uniprot IDs		F8W6N3 Q92560	O75604
PDB IDs		7VPW 8H1T 8SVF	2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Protein Modification Process Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Nucleus Protein Metabolic Process Telomere Maintenance Via Telomere Trimming Nuclear Body Cysteine-type Peptidase Activity Heterochromatin Formation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nucleoplasm Epigenetic Regulation Of Gene Expression Macromolecule Metabolic Process Response To Radiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Negative Regulation Of MiRNA Transcription Structural Constituent Of Chromatin Cysteine-type Deubiquitinase Activity Apoptotic Signaling Pathway Response To Light Stimulus Chromosome Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Deubiquitination Regulation Of Cell Communication Regulation Of Signaling Telomere Maintenance Negative Regulation Of Metabolic Process BRCA1-C Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Localization To Chromosome Negative Regulation Of Growth Double-strand Break Repair Protein Modification By Small Protein Removal Nucleosome DNA Damage Response Telomere Organization Ubiquitin-modified Histone Reader Activity Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Repair Recombinational Repair Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction	Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Identical Protein Binding Ubiquitin-protein Transferase Activity Protein Modification Process Cytoskeleton Cytoplasm Cytosol Zinc Ion Binding Regulation Of Apoptotic Process Innate Immune Response Suppression Of Viral Release By Host Regulation Of Programmed Cell Death Protein Binding Defense Response To Other Organism Immune Response Immune System Process Protein Metabolic Process Defense Response To Symbiont Organelle Organization Response To External Biotic Stimulus Protein Polyubiquitination Response To Other Organism Metal Ion Binding Positive Regulation Of Catabolic Process Cytoskeleton Organization Cell Death Ubiquitin Protein Ligase Binding Defense Response Proteolysis Involved In Protein Catabolic Process Transferase Activity Transcription Coactivator Activity Programmed Cell Death Intermediate Filament Cytoskeleton Organization Apoptotic Process Intermediate Filament-based Process Regulation Of Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Intermediate Filament Organization Regulation Of Signal Transduction Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signaling Adaptor Activity Negative Regulation Of Programmed Cell Death
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