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RBBP4 and TK1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
RBBP4
TK1
Description
RB binding protein 4, chromatin remodeling factor
thymidine kinase 1
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Chromosome
Cytosol
NuRD Complex
NURF Complex
Protein-containing Complex
CAF-1 Complex
ESC/E(Z) Complex
Sin3-type Complex
ATPase Complex
Nucleus
Cytoplasm
Cytosol
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Protein Binding
ATP-dependent Activity, Acting On DNA
Nucleosomal DNA Binding
Histone Binding
Histone Deacetylase Binding
Nucleotide Binding
Thymidine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Replication
DNA Repair
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Chromatin Assembly
Chromatin Remodeling
Regulation Of DNA-templated Transcription
DNA Damage Response
Brain Development
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cell Fate Specification
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Stem Cell Population Maintenance
Regulation Of Stem Cell Differentiation
Nucleobase-containing Compound Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Thymidine Metabolic Process
Thymidine Biosynthetic Process
Protein Homotetramerization
DNA Biosynthetic Process
DNA Synthesis Involved In Mitotic DNA Replication
Pathways
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
Polo-like kinase mediated events
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Deposition of new CENPA-containing nucleosomes at the centromere
Regulation of TP53 Activity through Acetylation
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin A:Cdk2-associated events at S phase entry
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
HCMV Early Events
Potential therapeutics for SARS
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Regulation of endogenous retroelements by KRAB-ZFP proteins
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
G1/S-Specific Transcription
Pyrimidine salvage
Drugs
Dithioerythritol
Thymidine 5'-triphosphate
Diseases
GWAS
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Leukocyte telomere length (
32109421
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
27863252
28957414
32888494
)
Interacting Genes
59 interacting genes:
AEBP2
ANXA7
ARMC12
BRCA1
BRMS1
BRMS1L
CDKN1A
CHAF1B
CREB1
CREBBP
CYTOR
DDB1
DHX30
ESR1
EXOSC8
FOXK2
H1-1
H2AC20
H3-4
H3C1
H3C14
H4C14
H4C16
HDAC1
HDAC2
HDAC3
HDAC4
HMOX2
ING1
KPNA5
LIN9
LMNA
MBD2
MBD3
MTA1
MTA2
NR2E3
PRDM16
RB1
RBBP7
RBP1
RPN1
RPN2
RYBP
SALL4
SAP30
SIN3A
SMN1
SNCA
SP1
SP3
SPEN
STAT5B
SUMO2
SUV39H1
TK1
TSSK3
USP7
XRCC6
166 interacting genes:
A1BG
A2M
AAMP
ABHD4
ACTB
ACTL6B
ACTR1B
ADAMTS10
ADD1
AGAP1
ALAS1
ALB
APLP1
APP
ARFGAP1
ATG16L2
ATP5F1B
ATP6V1A
ATXN3
BAG6
BOLA2
BOLA2B
CARHSP1
CCDC90B
CDC20
CDK1
CDK4
CDKN1A
CENPB
CFTR
CHGB
CLEC3B
COL11A2
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CRMP1
CSAD
DACT1
DALRD3
DCAF13
DDAH2
DEAF1
DMPK
DOCK7
DRAP1
DUS2
DYNC1I1
DYNC2I1
DYNLT2B
EEF1A1
EIF3G
EIF4A2
EIF6
ERG28
EXT2
EZH2
F13A1
FAF1
FAM20C
FBN3
FGB
FLAD1
FST
FZR1
GAPDH
GDF9
GDI1
GET3
GLB1
GPCPD1
HADHB
HERC3
HMGXB3
HSPBAP1
IER3IP1
IGHM
IMMT
INPP5K
INTS11
ITSN1
JADE1
JMJD1C
KDM6B
KIF21B
KIF5A
KLHL23
KLHL5
KMT2B
LRIF1
MAGEA4
MAST2
MED31
METTL23
MKI67
MPP1
MPPED1
MRFAP1
MRPL20-AS1
MRPL37
MSH2
NEUROD2
NGFR
NKIRAS2
NMT2
NRBP1
ODC1
PAAF1
PDE4DIP
PJA1
PKM
PLD3
PLXNA3
PPP4C
PRMT1
PROC
PSME1
PTPN4
PTPRK
QARS1
RBBP4
RBM48
REX1BD
RPA1
RPL13
RPS2
RUVBL1
RXRA
SDF4
SEMA5B
SEPTIN6
SETDB1
SEZ6L2
SMC5
SNX1
SP110
SULT1A3
SUMO2
SUMO3
TAF1C
THOC3
TIAM2
TLE1
TMSB4X
TP53
TRIM46
TRMT2A
TSC2
TTC38
TUBA1A
TUBB2A
TUBB3
TYK2
UBC
UNC119
UPF2
USP4
VMA22
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZXDC
Entrez ID
5928
7083
HPRD ID
04232
01771
Ensembl ID
ENSG00000162521
ENSG00000167900
Uniprot IDs
Q09028
A0A384MDV9
K7ERV3
K7ES52
P04183
PDB IDs
2XU7
3GFC
4PBY
4PBZ
4PC0
4R7A
5FXY
5VTB
5WAI
5WAK
5XWR
5XXQ
5Y1U
6BW3
6BW4
6C23
6C24
6G16
6NQ3
6WKR
6ZRC
6ZRD
7AOA
7KSO
7KSR
7KTP
7M40
7N40
7R1D
7Y5K
7Y5L
7Y5O
7Y5U
7Y5V
8EQV
8FYH
8IQF
8IQG
8T9G
8TAS
8TB9
8TX8
8VMI
8VML
8VNV
8VNZ
9C8U
9DCH
1W4R
1XBT
2ORV
2WVJ
Enriched GO Terms of Interacting Partners
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Chromatin Remodeling
Chromatin Organization
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Epigenetic Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Nucleus
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Heterochromatin Formation
Sin3-type Complex
Negative Regulation Of Stem Cell Population Maintenance
DNA Binding
Histone Deacetylase Complex
NuRD Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Transcription Repressor Complex
Regulation Of RNA Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Rhythmic Process
Chromatin Binding
Positive Regulation Of Stem Cell Population Maintenance
Regulation Of Macromolecule Metabolic Process
Protein-containing Complex
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cell Fate Specification
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Stem Cell Population Maintenance
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Regulation Of Developmental Process
Chromatin
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Histone Deacetylase Binding
Chromosome
Cytoplasm
Macromolecule Metabolic Process
Protein Metabolic Process
Platelet Alpha Granule Lumen
Chromatin Organization
Blood Microparticle
Negative Regulation Of Cell Cycle G1/S Phase Transition
Chromatin Remodeling
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Extracellular Exosome
Cytosol
Regulation Of DNA Replication
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein Binding
Nucleoplasm
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Transferase Activity
Nuclear Matrix
Regulation Of Protein Catabolic Process
DNA Synthesis Involved In Mitotic DNA Replication
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Macromolecule Biosynthetic Process
Chromosome, Telomeric Region
Positive Regulation Of Protein Metabolic Process
Cytoskeleton
Negative Regulation Of Cell Cycle Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein Tag Activity
Developmental Process
Growth Cone
Protein Modification Process
Cellular Response To Norepinephrine Stimulus
Response To Norepinephrine
Mitotic DNA Damage Checkpoint Signaling
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Oocyte Growth
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