RBBP4 and HIST2H2AC

Number of citations of the paper that reports this interaction (PMID 12628926)
122

Data Source:
HPRD (in vitro)

		RBBP4	HIST2H2AC
Gene Name		retinoblastoma binding protein 4	histone cluster 2, H2ac
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Sin3 Complex NuRD Complex NURF Complex CAF-1 Complex ESC/E(Z) Complex Protein Complex	Nucleosome Nucleus Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding DNA-dependent ATPase Activity Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding	Molecular_function DNA Binding Protein Heterodimerization Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Gene Expression Chromatin Assembly CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cell Cycle	Biological_process
Pathways		Chromosome Maintenance Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Epigenetic regulation of gene expression G2/M Transition G0 and Early G1 PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Nucleosome assembly Oxidative Stress Induced Senescence Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: AEBP2 ANXA7 BCL11B BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP DHX30 EED ESR1 EZH2 GATAD2B HAT1 HDAC1 HDAC2 HDAC3 HDAC4 HIST1H1A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMOX2 ING1 LINC00152 LMNA MBD2 MBD3 MBD3L2 MTA1 MTA2 NR2E3 RB1 RBBP7 RBP1 RPN1 RPN2 SAP30 SIN3A SMN1 SP1 SP3 SPEN SUV39H1 TK1 TSSK3 XRCC6	65 interactors: ANP32A ATXN7L3 BAP1 BARD1 BAZ1B BMI1 BRCA1 CDY1 CHFR COPRS CRP CTCFL CTDP1 DDB2 DNMT3L EIF2AK2 EP300 GATAD2A GATAD2B HAT1 HDAC2 HIST1H2BA HIST1H3A HIST1H4A HIST2H2BE HIST2H4A KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 SSRP1 TAF15 TAF1A TAF1B TCF20 TSPY1 TSSK6 UBC UBE2B UBR2 UIMC1 USP12 USP16 USP22 USP46
Entrez ID		5928	8338
HPRD ID		04232	09107
Ensembl ID		ENSG00000162521	ENSG00000184260
Uniprot IDs		Q09028	Q16777
PDB IDs		2XU7 3GFC
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Organelle Organization Histone Modification Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Metabolic Process Chromatin Remodeling Histone Deacetylation Positive Regulation Of Transcription, DNA-templated Protein Deacetylation Biosynthetic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Rhythmic Process Chromatin Silencing Histone H3-K9 Modification Positive Regulation Of Metabolic Process Metabolic Process	Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Organelle Organization Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Cellular Protein Metabolic Process Gene Expression Chromatin Remodeling Regulation Of Metabolic Process Chromatin Silencing Cellular Metabolic Process DNA Packaging Nucleosome Organization Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Chromatin Assembly Or Disassembly Negative Regulation Of Nucleic Acid-templated Transcription Histone H2A Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Histone Acetylation Nucleosome Assembly RNA Metabolic Process Protein-DNA Complex Assembly Internal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Cell Cycle Histone Deubiquitination Chromatin Assembly
Tagcloud ?		bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling repression su top
Tagcloud (Difference) ?		bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling repression su top
Tagcloud (Intersection) ?