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RBBP4 and HIST2H4A
Number of citations of the paper that reports this interaction (PMID
12628926
)
122
Data Source:
HPRD
(in vitro, in vivo)
RBBP4
HIST2H4A
Gene Name
retinoblastoma binding protein 4
histone cluster 2, H4a
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Nucleoplasm
Sin3 Complex
NuRD Complex
NURF Complex
CAF-1 Complex
ESC/E(Z) Complex
Protein Complex
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding
Protein Binding
DNA-dependent ATPase Activity
Nucleosomal DNA Binding
Histone Binding
Histone Deacetylase Binding
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Chromatin Remodeling
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Negative Regulation Of Cell Proliferation
Gene Expression
Chromatin Assembly
CENP-A Containing Nucleosome Assembly
Regulation Of Gene Expression, Epigenetic
ATP-dependent Chromatin Remodeling
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Cell Cycle
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Pathways
Chromosome Maintenance
Chromatin organization
HDACs deacetylate histones
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Epigenetic regulation of gene expression
G2/M Transition
G0 and Early G1
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
Chromatin modifying enzymes
Nucleosome assembly
Oxidative Stress Induced Senescence
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Polo-like kinase mediated events
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions
50 interactors:
AEBP2
ANXA7
BCL11B
BRCA1
BRMS1
BRMS1L
CDKN1A
CHAF1B
CREB1
CREBBP
DHX30
EED
ESR1
EZH2
GATAD2B
HAT1
HDAC1
HDAC2
HDAC3
HDAC4
HIST1H1A
HIST2H2AC
HIST2H3C
HIST2H4A
HIST3H3
HMOX2
ING1
LINC00152
LMNA
MBD2
MBD3
MBD3L2
MTA1
MTA2
NR2E3
RB1
RBBP7
RBP1
RPN1
RPN2
SAP30
SIN3A
SMN1
SP1
SP3
SPEN
SUV39H1
TK1
TSSK3
XRCC6
27 interactors:
ATAD2
BRD4
BRDT
DNMT3L
EP300
HAT1
HIST1H3A
HIST2H2AC
KAT2A
KAT5
LBR
NAP1L4
PRMT1
PTMA
RAD51B
RBBP4
RNF20
RPS6KA5
SET
TAF15
TBL1X
TBL1XR1
TP53BP1
UBC
UCHL5
UHRF1
YWHAQ
Entrez ID
5928
8370
HPRD ID
04232
11821
Ensembl ID
ENSG00000162521
ENSG00000183941
Uniprot IDs
Q09028
B2R4R0
P62805
PDB IDs
2XU7
3GFC
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Negative Regulation Of Gene Expression
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression, Epigenetic
Chromatin Modification
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Transcription, DNA-templated
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Cellular Nitrogen Compound Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
RNA Biosynthetic Process
Organelle Organization
Histone Modification
Regulation Of RNA Metabolic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
RNA Metabolic Process
Cellular Metabolic Process
Chromatin Remodeling
Histone Deacetylation
Positive Regulation Of Transcription, DNA-templated
Protein Deacetylation
Biosynthetic Process
ATP-dependent Chromatin Remodeling
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Metabolic Process
Rhythmic Process
Chromatin Silencing
Histone H3-K9 Modification
Positive Regulation Of Metabolic Process
Metabolic Process
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Organelle Organization
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Gene Expression
Negative Regulation Of RNA Biosynthetic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Transcription, DNA-templated
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
RNA Biosynthetic Process
Protein Acetylation
Nucleosome Organization
Negative Regulation Of Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
DNA Metabolic Process
DNA Replication-dependent Nucleosome Assembly
Positive Regulation Of Cellular Metabolic Process
Nucleosome Assembly
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
RNA Metabolic Process
Chromatin Assembly
Histone H4 Acetylation
Peptidyl-lysine Modification
DNA Methylation On Cytosine
Chromatin Assembly Or Disassembly
Positive Regulation Of Metabolic Process
Tagcloud
?
bfls
borjeson
charged
coregulator
deacetylase
disordered
fog1
forssman
gal4
homeodomain
impair
implicates
insert
lehmann
lymphoblastic
mta1
nucleosome
nurd
nurf55
overlaps
pair
phf6
pocket
propeller
recognizing
remodeling
repression
su
top
Tagcloud (Difference)
?
bfls
borjeson
charged
coregulator
deacetylase
disordered
fog1
forssman
gal4
homeodomain
impair
implicates
insert
lehmann
lymphoblastic
mta1
nucleosome
nurd
nurf55
overlaps
pair
phf6
pocket
propeller
recognizing
remodeling
repression
su
top
Tagcloud (Intersection)
?