PIM1 and CBX1

Number of citations of the paper that reports this interaction (PMID 12111331)
29

Data Source:
HPRD (in vitro, in vivo)

		PIM1	CBX1
Gene Name		Pim-1 proto-oncogene, serine/threonine kinase	chromobox homolog 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Chromosome, Centromeric Region Chromatin Female Pronucleus Male Pronucleus Nucleoplasm Nuclear Heterochromatin Pericentric Heterochromatin Spindle Chromocenter
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Manganese Ion Binding Ribosomal Small Subunit Binding	Chromatin Binding Protein Binding Enzyme Binding Protein Homodimerization Activity Histone Methyltransferase Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Cycle Multicellular Organismal Development Regulation Of Mitotic Cell Cycle Cell Proliferation Hyaluronan Metabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autophosphorylation	Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs		Adenosine monophosphate 3,4-Dihydroxy-1-Methylquinolin-2(1h)-One Staurosporine 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One Rbt205 Inhibitor Quercetin Phosphoaminophosphonic Acid-Adenylate Ester Phosphonoserine S,S-(2-Hydroxyethyl)Thiocysteine IMIDAZOPYRIDAZIN 1 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (4R)-7,8-dichloro-1\',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4\'-piperidine]-4-carbonitrile N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4\'-piperidine]-4-carbonitrile 5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine 2,3-diphenyl-1H-indole-7-carboxylic acid
Diseases
GWAS			Body mass index ( 20935630) Epilepsy (generalized) ( 22949513)
Protein-Protein Interactions		29 interactors: ABCB1 APP BAD BANP BEND7 CBX1 CBX3 CDC20 CDC25A CDKN1A EPHA3 FH FXR2 HEXIM2 HIST2H3C HIST3H3 HSP90AA1 MARK3 NFATC1 NHLH1 NUMA1 PPP2R4 PTPRO SHMT1 SKP2 SND1 SNX6 TFPT ZBTB1	29 interactors: ABI3BP ARL5A C11orf30 CBX3 CBX5 CHAF1A DNMT1 DNMT3A DNMT3B EHMT2 HIST1H1E HIST1H3A HIST1H3C HIST3H3 KLF11 LRIF1 NR2F6 NSL1 PCNA PIM1 RB1 RPL12 SP100 SUV39H1 TRIM24 TRIM28 UCHL1 VHL VTN
Entrez ID		5292	10951
HPRD ID		01292	05149
Ensembl ID		ENSG00000137193	ENSG00000108468
Uniprot IDs		P11309	P83916 Q6IBN6
PDB IDs		1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2O3P 2O63 2O64 2O65 2OBJ 2OI4 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 3A99 3BGP 3BGQ 3BGZ 3BWF 3C4E 3CXW 3CY2 3CY3 3DCV 3F2A 3JPV 3JXW 3JY0 3JYA 3MA3 3QF9 3R00 3R01 3R02 3R04 3T9I 3UIX 3UMW 3UMX 3VBQ 3VBT 3VBV 3VBW 3VBX 3VBY 3VC4 4A7C 4ALU 4ALV 4ALW 4AS0 4DTK 4ENX 4ENY 4GW8 4JX3 4JX7 4K0Y 4K18 4K1B 4MBI	2FMM 3F2U 3Q6S
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Cell Cycle Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Innate Immune Response Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transferase Activity Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Nitrogen Compound Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Biosynthetic Process Response To Glucocorticoid Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Neuron Recognition Response To Corticosteroid Axon Guidance Regulation Of Phosphorus Metabolic Process Cell Morphogenesis Involved In Differentiation Negative Regulation Of Transcription, DNA-templated Mitotic Spindle Organization In Nucleus Positive Regulation Of Pro-T Cell Differentiation Slit Diaphragm Assembly Cellular Response To Chromate Regulation Of Protein Kinase Activity Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription	DNA Methylation On Cytosine Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Methylation Negative Regulation Of Cellular Metabolic Process DNA Modification Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process Chromatin Silencing Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification DNA Metabolic Process Gene Silencing Regulation Of Gene Expression DNA Methylation On Cytosine Within A CG Sequence C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Methylation Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Organelle Organization Regulation Of Metabolic Process DNA Replication-dependent Nucleosome Assembly Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA RNA Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle S-adenosylmethioninamine Metabolic Process RNA Metabolic Process Transcription, DNA-templated Cellular Metabolic Process Nucleosome Assembly DNA Methylation Involved In Embryo Development S-adenosylhomocysteine Metabolic Process Chromatin Assembly Cellular Macromolecule Biosynthetic Process Nucleosome Organization
Tagcloud ?		bm6 bx1 chimera construct ectopic ectopically effectors epo erb1 erythropoietin fdc2 fdcp1 gata interactive kit mitogenesis mitogenic mo7e notion opposing presently progenitor responsiveness scf subdomain subline synergy ways	apobec3 ash2l cbx3 cbx5 cbx6 cbx7 chd3 chd4 dek dnmt3b hdac7 ino80e kat1 kdm1b kdm2b kdm5c kdm7 modifiers ncoa4 ontogenic ontogeny prmt1 prmt7 setd8 smarca2 smarca4 smarcb1 suv420h2 unveils
Tagcloud (Difference) ?		bm6 bx1 chimera construct ectopic ectopically effectors epo erb1 erythropoietin fdc2 fdcp1 gata interactive kit mitogenesis mitogenic mo7e notion opposing presently progenitor responsiveness scf subdomain subline synergy ways	apobec3 ash2l cbx3 cbx5 cbx6 cbx7 chd3 chd4 dek dnmt3b hdac7 ino80e kat1 kdm1b kdm2b kdm5c kdm7 modifiers ncoa4 ontogenic ontogeny prmt1 prmt7 setd8 smarca2 smarca4 smarcb1 suv420h2 unveils
Tagcloud (Intersection) ?