PIM1 and CBX1

Number of citations of the paper that reports this interaction (PubMedID 12111331)
0

Data Source:
HPRD (in vitro, in vivo)

		PIM1	CBX1
Description		Pim-1 proto-oncogene, serine/threonine kinase	chromobox 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane	Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Heterochromatin Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Chromocenter Nuclear Body Site Of DNA Damage
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Kinase Activity Transferase Activity Manganese Ion Binding Ribosomal Small Subunit Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity	Chromatin Binding Protein Binding Enzyme Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Transmembrane Transporter Activity Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Protein Stabilization Cytolysis In Another Organism Positive Regulation Of Cardiac Muscle Cell Proliferation Vitamin D Receptor Signaling Pathway Cellular Response To Type II Interferon Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Brown Fat Cell Differentiation Non-canonical Inflammasome Complex Assembly Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Cardioblast Proliferation Cellular Detoxification	DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription
Pathways		Interleukin-4 and Interleukin-13 signaling STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins	HCMV Early Events
Drugs		3,4-Dihydroxy-1-Methylquinolin-2(1h)-One Staurosporine LY-294002 Imidazole (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One Bisindolylmaleimide I Quercetin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine S,S-(2-Hydroxyethyl)Thiocysteine IMIDAZOPYRIDAZIN 1 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Tricetin 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine 2,3-diphenyl-1H-indole-7-carboxylic acid Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181) Birth weight ( 31043758) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Rosacea symptom severity ( 29771307)	Aspartate aminotransferase levels ( 33547301) Body mass index ( 20935630 26426971) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Generalized epilepsy ( 22949513)
Interacting Genes		34 interacting genes: ABCB1 APP BAD BANP BEND7 CBX1 CBX3 CDC20 CDC25A CDKN1A DAPK1 EGFR EPHA3 FBXO7 FH FXR2 H3-3A H3-4 H3C14 HEXIM2 HSP90AA1 NFATC1 NHLH1 NUMA1 PPP2CA PTPRO SENP1 SHMT1 SKP2 SND1 SNX6 TFPT UBE2I ZBTB1	34 interacting genes: ABI3BP ARL5A ATXN7L2 BAHD1 BARD1 BRCA1 CBX3 CBX5 CHAF1A DNMT1 DNMT3A DNMT3B EMSY H1-4 H3-4 H3C1 H3C3 HECW2 HSPB1 KLF11 LNX1 LRIF1 NR2F6 PCNA PIM1 RPL12 SP100 SUV39H1 TRIM24 TRIM28 UCHL1 VHL VTN ZNF280C
Entrez ID		5292	10951
HPRD ID		01292	05149
Ensembl ID		ENSG00000137193	ENSG00000108468
Uniprot IDs		P11309	P83916 Q6IBN6
PDB IDs		1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2O3P 2O63 2O64 2O65 2OBJ 2OI4 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 3A99 3BGP 3BGQ 3BGZ 3BWF 3C4E 3CXW 3CY2 3CY3 3DCV 3F2A 3JPV 3JXW 3JY0 3JYA 3MA3 3QF9 3R00 3R01 3R02 3R04 3T9I 3UIX 3UMW 3UMX 3VBQ 3VBT 3VBV 3VBW 3VBX 3VBY 3VC4 3WE8 4A7C 4ALU 4ALV 4ALW 4AS0 4BZN 4BZO 4DTK 4ENX 4ENY 4GW8 4I41 4IAA 4JX3 4JX7 4K0Y 4K18 4K1B 4LL5 4LM5 4LMU 4MBI 4MBL 4MTA 4N6Y 4N6Z 4N70 4RBL 4RC2 4RC3 4RC4 4RPV 4TY1 4WRS 4WSY 4WT6 4XH6 4XHK 5C1Q 5DGZ 5DHJ 5DIA 5DWR 5EOL 5IIS 5IPJ 5KCX 5KGD 5KGE 5KGG 5KGI 5KGK 5KZI 5MZL 5N4N 5N4O 5N4R 5N4U 5N4V 5N4X 5N4Y 5N4Z 5N50 5N51 5N52 5N5L 5N5M 5NDT 5O11 5O12 5O13 5TEL 5TEX 5TOE 5TUR 5V80 5V82 5VUA 5VUB 5VUC 6AYD 6BSK 6KZI 6L11 6L12 6L13 6L14 6L15 6L16 6L17 6MT0 6NO8 6NO9 6PCW 6PDI 6PDN 6PDO 6PDP 6QXK 6VRU 6VRV 6YKD 7OOV 7OOW 7OOX 7QB2 7QFM 7VSY 7XSV 7Z6U 7ZUN 8AFR 8R0H 8R0Q 8R0W 8R0Y 8R10 8R18 8R1K 8R1N 8R1P 8R1T 8R1W 8R25 8R27	2FMM 3F2U 3Q6S 5T1G 6D07 6D08
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleus Protein Heterodimerization Activity Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Nucleoplasm Positive Regulation Of DNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Catabolic Process Mitotic Cell Cycle Phase Transition Chromosome, Centromeric Region Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cellular Response To Cell-matrix Adhesion Chromatin Organization Regulation Of Gene Expression Chromatin Remodeling Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process Negative Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Positive Regulation Of DNA Replication Nuclear Body Extracellular Exosome Regulation Of DNA Replication Protein-containing Complex Regulation Of Chromosome Organization Positive Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Heterochromatin Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Positive Regulation Of DNA Repair Positive Regulation Of Protein Localization Regulation Of Protein Modification Process Cellular Response To Oxygen-containing Compound Protein Binding	Chromatin Organization Heterochromatin Chromatin Remodeling Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA (cytosine-5-)-methyltransferase Activity Nucleoplasm Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Euchromatin Chromo Shadow Domain Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Programming Of Gene Expression Negative Regulation Of Biosynthetic Process Ubiquitin-protein Transferase Activity Chromosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Regulation Of Primary Metabolic Process DNA Damage Response Nucleosome Assembly Histone H2AK127 Ubiquitin Ligase Activity Nucleus Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Macromolecule Metabolic Process BRCA1-BARD1 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Metabolic Process Nucleosome Organization DNA Binding Cellular Response To Stress DNA-methyltransferase Activity BRCA1-B Complex Cellular Response To Bisphenol A Structural Constituent Of Chromatin Pericentric Heterochromatin Post-translational Protein Modification Protein-DNA Complex Assembly
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