PIM1 and NFATC1

Number of citations of the paper that reports this interaction (PMID 11823475)
21

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PIM1	NFATC1
Gene Name		Pim-1 proto-oncogene, serine/threonine kinase	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Manganese Ion Binding Ribosomal Small Subunit Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding FK506 Binding Transcription Regulatory Region DNA Binding Mitogen-activated Protein Kinase P38 Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Cycle Multicellular Organismal Development Regulation Of Mitotic Cell Cycle Cell Proliferation Hyaluronan Metabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autophosphorylation	G1/S Transition Of Mitotic Cell Cycle Epithelial To Mesenchymal Transition Transcription From RNA Polymerase II Promoter Calcium Ion Transport Heart Development Osteoclast Differentiation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Ca2+ pathway Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling
Drugs		Adenosine monophosphate 3,4-Dihydroxy-1-Methylquinolin-2(1h)-One Staurosporine 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One Rbt205 Inhibitor Quercetin Phosphoaminophosphonic Acid-Adenylate Ester Phosphonoserine S,S-(2-Hydroxyethyl)Thiocysteine IMIDAZOPYRIDAZIN 1 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (4R)-7,8-dichloro-1\',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4\'-piperidine]-4-carbonitrile N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4\'-piperidine]-4-carbonitrile 5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine 2,3-diphenyl-1H-indole-7-carboxylic acid
Diseases
GWAS
Protein-Protein Interactions		29 interactors: ABCB1 APP BAD BANP BEND7 CBX1 CBX3 CDC20 CDC25A CDKN1A EPHA3 FH FXR2 HEXIM2 HIST2H3C HIST3H3 HSP90AA1 MARK3 NFATC1 NHLH1 NUMA1 PPP2R4 PTPRO SHMT1 SKP2 SND1 SNX6 TFPT ZBTB1	16 interactors: EGR1 EGR2 EP300 GNB2L1 HDAC5 KAT2B KPNB1 MAPK14 PARP1 PIAS1 PIM1 PPP3R1 PRKCA SPI1 TUBA1A YWHAQ
Entrez ID		5292	4772
HPRD ID		01292	02729
Ensembl ID		ENSG00000137193	ENSG00000131196
Uniprot IDs		P11309	A8K9C6 B4DER8 F5H4S8 O95644
PDB IDs		1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2O3P 2O63 2O64 2O65 2OBJ 2OI4 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 3A99 3BGP 3BGQ 3BGZ 3BWF 3C4E 3CXW 3CY2 3CY3 3DCV 3F2A 3JPV 3JXW 3JY0 3JYA 3MA3 3QF9 3R00 3R01 3R02 3R04 3T9I 3UIX 3UMW 3UMX 3VBQ 3VBT 3VBV 3VBW 3VBX 3VBY 3VC4 4A7C 4ALU 4ALV 4ALW 4AS0 4DTK 4ENX 4ENY 4GW8 4JX3 4JX7 4K0Y 4K18 4K1B 4MBI	1A66 1NFA
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Cell Cycle Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Innate Immune Response Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transferase Activity Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Nitrogen Compound Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Biosynthetic Process Response To Glucocorticoid Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Neuron Recognition Response To Corticosteroid Axon Guidance Regulation Of Phosphorus Metabolic Process Cell Morphogenesis Involved In Differentiation Negative Regulation Of Transcription, DNA-templated Mitotic Spindle Organization In Nucleus Positive Regulation Of Pro-T Cell Differentiation Slit Diaphragm Assembly Cellular Response To Chromate Regulation Of Protein Kinase Activity Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Response To Peptide Peptidyl-lysine Modification Negative Regulation Of Gene Expression Response To Insulin Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription N-terminal Peptidyl-lysine Acetylation Regulation Of RNA Biosynthetic Process Peptidyl-amino Acid Modification Rhythmic Process Regulation Of RNA Metabolic Process Skeletal Muscle Tissue Development Leukocyte Differentiation Skeletal Muscle Organ Development Immune System Process Regulation Of Protein Metabolic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Histone Modification Regulation Of Signaling Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway RNA Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Regulation Of Protein Localization Innate Immune Response
Tagcloud ?		bm6 bx1 chimera construct ectopic ectopically effectors epo erb1 erythropoietin fdc2 fdcp1 gata interactive kit mitogenesis mitogenic mo7e notion opposing presently progenitor responsiveness scf subdomain subline synergy ways	124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting itgb1 killed leucocyte lewis luciferase micrornas mir osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Difference) ?		bm6 bx1 chimera construct ectopic ectopically effectors epo erb1 erythropoietin fdc2 fdcp1 gata interactive kit mitogenesis mitogenic mo7e notion opposing presently progenitor responsiveness scf subdomain subline synergy ways	124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting itgb1 killed leucocyte lewis luciferase micrornas mir osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Intersection) ?