PIM1 and SHMT1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PIM1	SHMT1
Gene Name		Pim-1 proto-oncogene, serine/threonine kinase	serine hydroxymethyltransferase 1 (soluble)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Manganese Ion Binding Ribosomal Small Subunit Binding	Glycine Hydroxymethyltransferase Activity L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Cycle Multicellular Organismal Development Regulation Of Mitotic Cell Cycle Cell Proliferation Hyaluronan Metabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autophosphorylation	L-serine Catabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Purine Nucleobase Biosynthetic Process Glycine Biosynthetic Process From Serine Cellular Nitrogen Compound Metabolic Process Tetrahydrofolate Interconversion Small Molecule Metabolic Process Carnitine Biosynthetic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization
Pathways			Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Metabolism of amino acids and derivatives Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Carnitine synthesis Metabolism of folate and pterines Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs		Adenosine monophosphate 3,4-Dihydroxy-1-Methylquinolin-2(1h)-One Staurosporine 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One Rbt205 Inhibitor Quercetin Phosphoaminophosphonic Acid-Adenylate Ester Phosphonoserine S,S-(2-Hydroxyethyl)Thiocysteine IMIDAZOPYRIDAZIN 1 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (4R)-7,8-dichloro-1\',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4\'-piperidine]-4-carbonitrile N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4\'-piperidine]-4-carbonitrile 5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine 2,3-diphenyl-1H-indole-7-carboxylic acid	Pyridoxal Phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-Formyl-Tetrahydrofolate 5-Hydroxymethylene-6-Hydrofolic Acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS
Protein-Protein Interactions		29 interactors: ABCB1 APP BAD BANP BEND7 CBX1 CBX3 CDC20 CDC25A CDKN1A EPHA3 FH FXR2 HEXIM2 HIST2H3C HIST3H3 HSP90AA1 MARK3 NFATC1 NHLH1 NUMA1 PPP2R4 PTPRO SHMT1 SKP2 SND1 SNX6 TFPT ZBTB1	7 interactors: CSNK2B DEDD DLEU1 MAPK9 PIM1 PRSS23 SULT1A3
Entrez ID		5292	6470
HPRD ID		01292	01643
Ensembl ID		ENSG00000137193	ENSG00000176974
Uniprot IDs		P11309	B4DPM9 P34896
PDB IDs		1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2O3P 2O63 2O64 2O65 2OBJ 2OI4 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 3A99 3BGP 3BGQ 3BGZ 3BWF 3C4E 3CXW 3CY2 3CY3 3DCV 3F2A 3JPV 3JXW 3JY0 3JYA 3MA3 3QF9 3R00 3R01 3R02 3R04 3T9I 3UIX 3UMW 3UMX 3VBQ 3VBT 3VBV 3VBW 3VBX 3VBY 3VC4 4A7C 4ALU 4ALV 4ALW 4AS0 4DTK 4ENX 4ENY 4GW8 4JX3 4JX7 4K0Y 4K18 4K1B 4MBI	1BJ4
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Cell Cycle Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Innate Immune Response Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transferase Activity Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Nitrogen Compound Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Biosynthetic Process Response To Glucocorticoid Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Neuron Recognition Response To Corticosteroid Axon Guidance Regulation Of Phosphorus Metabolic Process Cell Morphogenesis Involved In Differentiation Negative Regulation Of Transcription, DNA-templated Mitotic Spindle Organization In Nucleus Positive Regulation Of Pro-T Cell Differentiation Slit Diaphragm Assembly Cellular Response To Chromate Regulation Of Protein Kinase Activity Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter JUN Phosphorylation Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Positive Regulation Of Prostaglandin Biosynthetic Process Cell Death Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Endothelial Tube Morphogenesis Protein Phosphorylation Apoptotic Signaling Pathway Protein Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of Apoptotic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Cell Death Positive Regulation Of Icosanoid Secretion Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Metabolic Process Sulfation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Fatty Acid Transport Flavonoid Metabolic Process Decidualization Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Tagcloud ?		bm6 bx1 chimera construct ectopic ectopically effectors epo erb1 erythropoietin fdc2 fdcp1 gata interactive kit mitogenesis mitogenic mo7e notion opposing presently progenitor responsiveness scf subdomain subline synergy ways	aa aas african american ancestry asian associations carbon circle comparisons copyright correcting ea eas eleven european folate metabolizing modest mtr mtrr participated polygenetic polymorphisms reserved rights slc19a1 snps tyms
Tagcloud (Difference) ?		bm6 bx1 chimera construct ectopic ectopically effectors epo erb1 erythropoietin fdc2 fdcp1 gata interactive kit mitogenesis mitogenic mo7e notion opposing presently progenitor responsiveness scf subdomain subline synergy ways	aa aas african american ancestry asian associations carbon circle comparisons copyright correcting ea eas eleven european folate metabolizing modest mtr mtrr participated polygenetic polymorphisms reserved rights slc19a1 snps tyms
Tagcloud (Intersection) ?