PIM1 and SENP1

Number of citations of the paper that reports this interaction (PubMedID 28620180)
46

Data Source:
BioGRID (enzymatic study)

		PIM1	SENP1
Description		Pim-1 proto-oncogene, serine/threonine kinase	SUMO specific peptidase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Kinase Activity Transferase Activity Manganese Ion Binding Ribosomal Small Subunit Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity	Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Transmembrane Transporter Activity Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Protein Stabilization Cytolysis In Another Organism Positive Regulation Of Cardiac Muscle Cell Proliferation Vitamin D Receptor Signaling Pathway Cellular Response To Type II Interferon Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Brown Fat Cell Differentiation Non-canonical Inflammasome Complex Assembly Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Cardioblast Proliferation Cellular Detoxification	Proteolysis Regulation Of Definitive Erythrocyte Differentiation Protein Sumoylation Protein Desumoylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process MRNA Destabilization Regulation Of Primary Metabolic Process Regulation Of Postsynapse Assembly
Pathways		Interleukin-4 and Interleukin-13 signaling STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins	SUMO is proteolytically processed RHOF GTPase cycle
Drugs		3,4-Dihydroxy-1-Methylquinolin-2(1h)-One Staurosporine LY-294002 Imidazole (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One Bisindolylmaleimide I Quercetin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine S,S-(2-Hydroxyethyl)Thiocysteine IMIDAZOPYRIDAZIN 1 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Tricetin 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine 2,3-diphenyl-1H-indole-7-carboxylic acid Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181) Birth weight ( 31043758) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Rosacea symptom severity ( 29771307)	Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)
Interacting Genes		34 interacting genes: ABCB1 APP BAD BANP BEND7 CBX1 CBX3 CDC20 CDC25A CDKN1A DAPK1 EGFR EPHA3 FBXO7 FH FXR2 H3-3A H3-4 H3C14 HEXIM2 HSP90AA1 NFATC1 NHLH1 NUMA1 PPP2CA PTPRO SENP1 SHMT1 SKP2 SND1 SNX6 TFPT UBE2I ZBTB1	26 interacting genes: APP CAV3 EIF5A GCM1 HDAC1 HIPK1 HIPK2 KCNK1 MORC2 NACC1 PARP1 PIAS3 PIM1 PML RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28 USP7
Entrez ID		5292	29843
HPRD ID		01292	07153
Ensembl ID		ENSG00000137193	ENSG00000079387
Uniprot IDs		P11309	Q9P0U3
PDB IDs		1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2O3P 2O63 2O64 2O65 2OBJ 2OI4 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 3A99 3BGP 3BGQ 3BGZ 3BWF 3C4E 3CXW 3CY2 3CY3 3DCV 3F2A 3JPV 3JXW 3JY0 3JYA 3MA3 3QF9 3R00 3R01 3R02 3R04 3T9I 3UIX 3UMW 3UMX 3VBQ 3VBT 3VBV 3VBW 3VBX 3VBY 3VC4 3WE8 4A7C 4ALU 4ALV 4ALW 4AS0 4BZN 4BZO 4DTK 4ENX 4ENY 4GW8 4I41 4IAA 4JX3 4JX7 4K0Y 4K18 4K1B 4LL5 4LM5 4LMU 4MBI 4MBL 4MTA 4N6Y 4N6Z 4N70 4RBL 4RC2 4RC3 4RC4 4RPV 4TY1 4WRS 4WSY 4WT6 4XH6 4XHK 5C1Q 5DGZ 5DHJ 5DIA 5DWR 5EOL 5IIS 5IPJ 5KCX 5KGD 5KGE 5KGG 5KGI 5KGK 5KZI 5MZL 5N4N 5N4O 5N4R 5N4U 5N4V 5N4X 5N4Y 5N4Z 5N50 5N51 5N52 5N5L 5N5M 5NDT 5O11 5O12 5O13 5TEL 5TEX 5TOE 5TUR 5V80 5V82 5VUA 5VUB 5VUC 6AYD 6BSK 6KZI 6L11 6L12 6L13 6L14 6L15 6L16 6L17 6MT0 6NO8 6NO9 6PCW 6PDI 6PDN 6PDO 6PDP 6QXK 6VRU 6VRV 6YKD 7OOV 7OOW 7OOX 7QB2 7QFM 7VSY 7XSV 7Z6U 7ZUN 8AFR 8R0H 8R0Q 8R0W 8R0Y 8R10 8R18 8R1K 8R1N 8R1P 8R1T 8R1W 8R25 8R27	2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleus Protein Heterodimerization Activity Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Nucleoplasm Positive Regulation Of DNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Catabolic Process Mitotic Cell Cycle Phase Transition Chromosome, Centromeric Region Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cellular Response To Cell-matrix Adhesion Chromatin Organization Regulation Of Gene Expression Chromatin Remodeling Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process Negative Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Positive Regulation Of DNA Replication Nuclear Body Extracellular Exosome Regulation Of DNA Replication Protein-containing Complex Regulation Of Chromosome Organization Positive Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Heterochromatin Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Positive Regulation Of DNA Repair Positive Regulation Of Protein Localization Regulation Of Protein Modification Process Cellular Response To Oxygen-containing Compound Protein Binding	Protein Sumoylation Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteolysis Protein Modification Process Post-translational Protein Modification Protein Metabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process SUMO Transferase Activity Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Organization Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Protein Tag Activity Protein-containing Complex Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Intracellular Transport Cellular Response To Stress Cytoplasmic Periphery Of The Nuclear Pore Complex DNA Damage Response Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nuclear Body Organization Negative Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Protein Localization Deubiquitinase Activity Maintenance Of Protein Location In Nucleus Ubiquitin-like Protein Ligase Binding Nuclear Pore Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Postsynaptic Cytosol Negative Regulation Of Transcription By RNA Polymerase II SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments
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