HNRNPD and MTA2

Number of citations of the paper that reports this interaction (PubMedID 18413351)
51

Data Source:
BioGRID (affinity chromatography technology, pull down)

		HNRNPD	MTA2
Description		heterogeneous nuclear ribonucleoprotein D	metastasis associated 1 family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Synapse Glutamatergic Synapse MCRD-mediated MRNA Stability Complex Ribonucleoprotein Complex	Histone Deacetylase Complex Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Telomeric DNA Binding Histone Deacetylase Binding	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Liver Development Regulation Of DNA-templated Transcription RNA Processing RNA Catabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cerebellum Development Positive Regulation Of Telomere Maintenance Via Telomerase Response To Estradiol Regulation Of Circadian Rhythm Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Response To Calcium Ion Response To Electrical Stimulus 3'-UTR-mediated MRNA Destabilization CRD-mediated MRNA Stabilization Cellular Response To Amino Acid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Nitric Oxide Circadian Regulation Of Translation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Response To Rapamycin Positive Regulation Of Telomere Capping Response To Sodium Phosphate Cellular Response To Putrescine Hepatocyte Dedifferentiation Positive Regulation Of Cytoplasmic Translation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Fibroblast Migration Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Genomic Imprinting Regulation Of Stem Cell Differentiation
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs		Artenimol
Diseases
GWAS		Chronotype ( 30696823) Coronary artery disease ( 32469254 33020668) Liver enzyme levels (alkaline phosphatase) ( 33972514) Morning person ( 30696823) Refractive error ( 32231278)	Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		98 interacting genes: ABCC10 ACTB ADGRE5 ARF4 B3GAT3 BET1L BRCA1 C1QBP CAPN1 CD81 CEBPA CINP COG7 COL18A1 CSDE1 CTSB CUTA DGCR2 DHX30 DMAC1 EEF2 ERG ESR1 EXOSC4 FBXL15 FILNC1 FLNA FNDC3B FOS FOXP1 GSK3B GTF3C3 GTSE1 GUK1 HBZ HDAC1 HIRA HMGA1 HNRNPH3 HSPA4 HSPB1 HSPB2 IGF2BP2 IL6 IL7R IMMP2L IMMT ING4 LDHA LINC01232 LSM5 MAP2K1 MAPK6 MEOX2 MPP1 MTA2 MYC NEDD4L NTMT1 OGT P4HB PABPC1 PCBP1 PCBP2 PCSK7 PDLIM7 PEX10 PPOX PRDX3 PRKACA PTBP2 PYCR1 RALY RPSA SAFB SDF2 SEPTIN9 SF3B4 SFN SHISA5 SLC27A5 SLC3A2 SNAPC4 SREK1 SUMO4 SYNCRIP TNF TNPO1 TOP2A TRN-GTT2-7 TSEN34 UBE2I UCP3 UQCRC1 VEGFA VHL YBX1 ZMYM4	24 interacting genes: APPL1 APPL2 CEBPA CUL4B DDB1 ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1
Entrez ID		3184	9219
HPRD ID		03206	07233
Ensembl ID		ENSG00000138668	ENSG00000149480
Uniprot IDs		Q14103	O94776
PDB IDs		1HD0 1HD1 1IQT 1WTB 1X0F 2Z5N 5IM0
Enriched GO Terms of Interacting Partners?		RNA Binding CRD-mediated MRNA Stabilization Macromolecule Metabolic Process Positive Regulation Of Translation Ribonucleoprotein Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Programmed Cell Death RNA Metabolic Process Nucleic Acid Binding Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Cytoplasmic Translation MCRD-mediated MRNA Stability Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II CRD-mediated MRNA Stability Complex Positive Regulation Of Gene Expression Transcription Coregulator Binding Regulation Of Gene Expression Regulation Of Translation Nucleic Acid Metabolic Process Regulation Of MiRNA Transcription Focal Adhesion Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Splicing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Processing Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex Nucleoplasm Negative Regulation Of Catabolic Process Regulation Of DNA-templated Transcription Regulation Of MiRNA Metabolic Process	Chromatin Remodeling Chromatin Organization Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nuclear Matrix DNA Binding Negative Regulation Of Macromolecule Metabolic Process NuRD Complex Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macropinocytosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Response To UV Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Specification Regulation Of DNA-templated Transcription Initiation Cellular Response To UV Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Light Stimulus Transcription Regulator Complex Macropinosome Nuclear Lumen Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phase Transition Cul4B-RING E3 Ubiquitin Ligase Complex
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