HNRNPD and ADGRE5

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		HNRNPD	ADGRE5
Description		heterogeneous nuclear ribonucleoprotein D	adhesion G protein-coupled receptor E5
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Synapse Glutamatergic Synapse MCRD-mediated MRNA Stability Complex Ribonucleoprotein Complex	Extracellular Region Plasma Membrane Focal Adhesion Membrane Secretory Granule Membrane Extracellular Exosome
	Molecular Function	Nucleic Acid Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Telomeric DNA Binding Histone Deacetylase Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding
	Biological Process	Liver Development Regulation Of DNA-templated Transcription RNA Processing RNA Catabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cerebellum Development Positive Regulation Of Telomere Maintenance Via Telomerase Response To Estradiol Regulation Of Circadian Rhythm Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Response To Calcium Ion Response To Electrical Stimulus 3'-UTR-mediated MRNA Destabilization CRD-mediated MRNA Stabilization Cellular Response To Amino Acid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Nitric Oxide Circadian Regulation Of Translation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Response To Rapamycin Positive Regulation Of Telomere Capping Response To Sodium Phosphate Cellular Response To Putrescine Hepatocyte Dedifferentiation Positive Regulation Of Cytoplasmic Translation	Immune System Process Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Class B/2 (Secretin family receptors) Neutrophil degranulation
Drugs		Artenimol
Diseases
GWAS		Chronotype ( 30696823) Coronary artery disease ( 32469254 33020668) Liver enzyme levels (alkaline phosphatase) ( 33972514) Morning person ( 30696823) Refractive error ( 32231278)
Interacting Genes		98 interacting genes: ABCC10 ACTB ADGRE5 ARF4 B3GAT3 BET1L BRCA1 C1QBP CAPN1 CD81 CEBPA CINP COG7 COL18A1 CSDE1 CTSB CUTA DGCR2 DHX30 DMAC1 EEF2 ERG ESR1 EXOSC4 FBXL15 FILNC1 FLNA FNDC3B FOS FOXP1 GSK3B GTF3C3 GTSE1 GUK1 HBZ HDAC1 HIRA HMGA1 HNRNPH3 HSPA4 HSPB1 HSPB2 IGF2BP2 IL6 IL7R IMMP2L IMMT ING4 LDHA LINC01232 LSM5 MAP2K1 MAPK6 MEOX2 MPP1 MTA2 MYC NEDD4L NTMT1 OGT P4HB PABPC1 PCBP1 PCBP2 PCSK7 PDLIM7 PEX10 PPOX PRDX3 PRKACA PTBP2 PYCR1 RALY RPSA SAFB SDF2 SEPTIN9 SF3B4 SFN SHISA5 SLC27A5 SLC3A2 SNAPC4 SREK1 SUMO4 SYNCRIP TNF TNPO1 TOP2A TRN-GTT2-7 TSEN34 UBE2I UCP3 UQCRC1 VEGFA VHL YBX1 ZMYM4	3 interacting genes: CD55 HNRNPD XRN1
Entrez ID		3184	976
HPRD ID		03206	03130
Ensembl ID		ENSG00000138668	ENSG00000123146
Uniprot IDs		Q14103	P48960
PDB IDs		1HD0 1HD1 1IQT 1WTB 1X0F 2Z5N 5IM0	2BOU 7DO4 7YDH 7YDJ 7YDM 7YDP 8IKJ 8IKL
Enriched GO Terms of Interacting Partners?		RNA Binding CRD-mediated MRNA Stabilization Macromolecule Metabolic Process Positive Regulation Of Translation Ribonucleoprotein Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Programmed Cell Death RNA Metabolic Process Nucleic Acid Binding Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Cytoplasmic Translation MCRD-mediated MRNA Stability Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II CRD-mediated MRNA Stability Complex Positive Regulation Of Gene Expression Transcription Coregulator Binding Regulation Of Gene Expression Regulation Of Translation Nucleic Acid Metabolic Process Regulation Of MiRNA Transcription Focal Adhesion Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Splicing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Processing Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex Nucleoplasm Negative Regulation Of Catabolic Process Regulation Of DNA-templated Transcription Regulation Of MiRNA Metabolic Process	Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Hepatocyte Dedifferentiation Regulation Of Telomere Maintenance Cellular Response To Putrescine Regulation Of DNA Biosynthetic Process Cellular Response To Puromycin Cellular Response To Cycloheximide Circadian Regulation Of Translation Response To Rapamycin RNA Catabolic Process Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Response To Ketone Regulation Of Chromosome Organization Response To Alcohol Response To Cycloheximide 5'-3' RNA Exonuclease Activity G-quadruplex RNA Binding Golgi Trans Cisterna Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding G-quadruplex DNA Binding Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Nucleobase-containing Compound Catabolic Process CRD-mediated MRNA Stabilization 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Complement Activation Regulation Of Telomere Capping Regulation Of Translation Histone MRNA Catabolic Process Cellular Response To Nitric Oxide RRNA Catabolic Process Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Cellular Response To Reactive Nitrogen Species Regulation Of Complement Activation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Respiratory Burst Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of DNA Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Telomere Maintenance Via Telomerase Response To Salt Response To Nitric Oxide Response To Ether
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