HNRNPD and PPOX

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		HNRNPD	PPOX
Description		heterogeneous nuclear ribonucleoprotein D	protoporphyrinogen oxidase
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Synapse Glutamatergic Synapse MCRD-mediated MRNA Stability Complex Ribonucleoprotein Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane
	Molecular Function	Nucleic Acid Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Telomeric DNA Binding Histone Deacetylase Binding	Oxygen-dependent Protoporphyrinogen Oxidase Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Liver Development Regulation Of DNA-templated Transcription RNA Processing RNA Catabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cerebellum Development Positive Regulation Of Telomere Maintenance Via Telomerase Response To Estradiol Regulation Of Circadian Rhythm Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Response To Calcium Ion Response To Electrical Stimulus 3'-UTR-mediated MRNA Destabilization CRD-mediated MRNA Stabilization Cellular Response To Amino Acid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Nitric Oxide Circadian Regulation Of Translation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Response To Rapamycin Positive Regulation Of Telomere Capping Response To Sodium Phosphate Cellular Response To Putrescine Hepatocyte Dedifferentiation Positive Regulation Of Cytoplasmic Translation	Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Protoporphyrinogen IX Metabolic Process Heme O Biosynthetic Process
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Heme biosynthesis
Drugs		Artenimol
Diseases			Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS		Chronotype ( 30696823) Coronary artery disease ( 32469254 33020668) Liver enzyme levels (alkaline phosphatase) ( 33972514) Morning person ( 30696823) Refractive error ( 32231278)
Interacting Genes		98 interacting genes: ABCC10 ACTB ADGRE5 ARF4 B3GAT3 BET1L BRCA1 C1QBP CAPN1 CD81 CEBPA CINP COG7 COL18A1 CSDE1 CTSB CUTA DGCR2 DHX30 DMAC1 EEF2 ERG ESR1 EXOSC4 FBXL15 FILNC1 FLNA FNDC3B FOS FOXP1 GSK3B GTF3C3 GTSE1 GUK1 HBZ HDAC1 HIRA HMGA1 HNRNPH3 HSPA4 HSPB1 HSPB2 IGF2BP2 IL6 IL7R IMMP2L IMMT ING4 LDHA LINC01232 LSM5 MAP2K1 MAPK6 MEOX2 MPP1 MTA2 MYC NEDD4L NTMT1 OGT P4HB PABPC1 PCBP1 PCBP2 PCSK7 PDLIM7 PEX10 PPOX PRDX3 PRKACA PTBP2 PYCR1 RALY RPSA SAFB SDF2 SEPTIN9 SF3B4 SFN SHISA5 SLC27A5 SLC3A2 SNAPC4 SREK1 SUMO4 SYNCRIP TNF TNPO1 TOP2A TRN-GTT2-7 TSEN34 UBE2I UCP3 UQCRC1 VEGFA VHL YBX1 ZMYM4	4 interacting genes: COPS5 HAP1 HNRNPD IMMT
Entrez ID		3184	5498
HPRD ID		03206	02953
Ensembl ID		ENSG00000138668	ENSG00000143224
Uniprot IDs		Q14103	B4DY76 P50336
PDB IDs		1HD0 1HD1 1IQT 1WTB 1X0F 2Z5N 5IM0	3NKS 4IVM 4IVO
Enriched GO Terms of Interacting Partners?		RNA Binding CRD-mediated MRNA Stabilization Macromolecule Metabolic Process Positive Regulation Of Translation Ribonucleoprotein Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Programmed Cell Death RNA Metabolic Process Nucleic Acid Binding Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Cytoplasmic Translation MCRD-mediated MRNA Stability Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II CRD-mediated MRNA Stability Complex Positive Regulation Of Gene Expression Transcription Coregulator Binding Regulation Of Gene Expression Regulation Of Translation Nucleic Acid Metabolic Process Regulation Of MiRNA Transcription Focal Adhesion Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Splicing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Processing Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex Nucleoplasm Negative Regulation Of Catabolic Process Regulation Of DNA-templated Transcription Regulation Of MiRNA Metabolic Process	Cerebellum Development Hepatocyte Dedifferentiation Cellular Response To Putrescine Positive Regulation Of Neurotrophin Production Establishment Of Vesicle Localization Vesicle Localization Circadian Regulation Of Translation Synaptic Vesicle Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Macrophage Migration Inhibitory Factor Binding Synapse Brain-derived Neurotrophic Factor Binding Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Exocytosis Exosomal Secretion Response To Rapamycin Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Establishment Of Organelle Localization Hypothalamus Cell Differentiation DeNEDDylase Activity Mitochondrial Crista Junction MICOS Complex Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Protein Metabolic Process Regulation Of Non-motile Cilium Assembly Protein Deneddylation Metal-dependent Deubiquitinase Activity SAM Complex Cristae Formation MIB Complex Secretion By Cell Cellular Response To Nitric Oxide Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Regulation Of Telomere Capping Cellular Response To Reactive Nitrogen Species Organelle Localization Positive Regulation Of Synaptic Transmission, GABAergic Mitochondrion Distribution Neurotrophin TRK Receptor Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Eukaryotic Translation Initiation Factor 3 Complex Mitochondrial Envelope
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