HNRNPD and PYCR1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		HNRNPD	PYCR1
Description		heterogeneous nuclear ribonucleoprotein D	pyrroline-5-carboxylate reductase 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Synapse Glutamatergic Synapse MCRD-mediated MRNA Stability Complex Ribonucleoprotein Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Nucleic Acid Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Telomeric DNA Binding Histone Deacetylase Binding	Pyrroline-5-carboxylate Reductase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding
	Biological Process	Liver Development Regulation Of DNA-templated Transcription RNA Processing RNA Catabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cerebellum Development Positive Regulation Of Telomere Maintenance Via Telomerase Response To Estradiol Regulation Of Circadian Rhythm Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Response To Calcium Ion Response To Electrical Stimulus 3'-UTR-mediated MRNA Destabilization CRD-mediated MRNA Stabilization Cellular Response To Amino Acid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Nitric Oxide Circadian Regulation Of Translation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Response To Rapamycin Positive Regulation Of Telomere Capping Response To Sodium Phosphate Cellular Response To Putrescine Hepatocyte Dedifferentiation Positive Regulation Of Cytoplasmic Translation	Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Mitochondrial Membrane Potential L-proline Biosynthetic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Glutamate and glutamine metabolism
Drugs		Artenimol	NADH Proline
Diseases			Geroderma osteodysplasticum
GWAS		Chronotype ( 30696823) Coronary artery disease ( 32469254 33020668) Liver enzyme levels (alkaline phosphatase) ( 33972514) Morning person ( 30696823) Refractive error ( 32231278)
Interacting Genes		98 interacting genes: ABCC10 ACTB ADGRE5 ARF4 B3GAT3 BET1L BRCA1 C1QBP CAPN1 CD81 CEBPA CINP COG7 COL18A1 CSDE1 CTSB CUTA DGCR2 DHX30 DMAC1 EEF2 ERG ESR1 EXOSC4 FBXL15 FILNC1 FLNA FNDC3B FOS FOXP1 GSK3B GTF3C3 GTSE1 GUK1 HBZ HDAC1 HIRA HMGA1 HNRNPH3 HSPA4 HSPB1 HSPB2 IGF2BP2 IL6 IL7R IMMP2L IMMT ING4 LDHA LINC01232 LSM5 MAP2K1 MAPK6 MEOX2 MPP1 MTA2 MYC NEDD4L NTMT1 OGT P4HB PABPC1 PCBP1 PCBP2 PCSK7 PDLIM7 PEX10 PPOX PRDX3 PRKACA PTBP2 PYCR1 RALY RPSA SAFB SDF2 SEPTIN9 SF3B4 SFN SHISA5 SLC27A5 SLC3A2 SNAPC4 SREK1 SUMO4 SYNCRIP TNF TNPO1 TOP2A TRN-GTT2-7 TSEN34 UBE2I UCP3 UQCRC1 VEGFA VHL YBX1 ZMYM4	7 interacting genes: BNIPL CDK2AP2 FXR1 HNRNPD NUDT21 SIRT3 TNPO2
Entrez ID		3184	5831
HPRD ID		03206	01528
Ensembl ID		ENSG00000138668	ENSG00000183010
Uniprot IDs		Q14103	E2QRB3 J3QL32 P32322 Q8TBX0
PDB IDs		1HD0 1HD1 1IQT 1WTB 1X0F 2Z5N 5IM0	2GER 2GR9 2GRA 2IZZ 5UAT 5UAU 5UAV 5UAW 5UAX 6XOZ 6XP0 6XP1 6XP2 6XP3 8DKG 8TCU 8TCV 8TCW 8TCX 8TCY 8TCZ 8TD0 8TD1 8TD2 8TD3 8TD4 8TD5 8TD6 8TD7 8TD8 8TD9 8TDB 8TDC 8TDD 8VRE
Enriched GO Terms of Interacting Partners?		RNA Binding CRD-mediated MRNA Stabilization Macromolecule Metabolic Process Positive Regulation Of Translation Ribonucleoprotein Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Programmed Cell Death RNA Metabolic Process Nucleic Acid Binding Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Cytoplasmic Translation MCRD-mediated MRNA Stability Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II CRD-mediated MRNA Stability Complex Positive Regulation Of Gene Expression Transcription Coregulator Binding Regulation Of Gene Expression Regulation Of Translation Nucleic Acid Metabolic Process Regulation Of MiRNA Transcription Focal Adhesion Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Splicing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Processing Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex Nucleoplasm Negative Regulation Of Catabolic Process Regulation Of DNA-templated Transcription Regulation Of MiRNA Metabolic Process	MRNA 3'-UTR AU-rich Region Binding Negative Regulation Of MRNA Catabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine MRNA Binding Positive Regulation Of Pro-B Cell Differentiation Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of RNA Catabolic Process Regulation Of Circadian Rhythm Negative Regulation Of MRNA Metabolic Process Circadian Regulation Of Translation Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Histone Deacetylase Binding Nucleus Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Lymphoid Progenitor Cell Differentiation Peptidyl-lysine Deacetylation Positive Regulation Of Oxidative Phosphorylation Post-transcriptional Regulation Of Gene Expression Positive Regulation Of MRNA Metabolic Process MRNA Alternative Polyadenylation Positive Regulation Of Translation Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex RNA Strand Annealing Activity Nuclear Pore Localization Histone Deacetylase Activity, NAD-dependent Regulation Of Growth Rate Response To Rapamycin Regulation Of MRNA Stability Cell Dedifferentiation Intracellular Membraneless Organelle MRNA Cleavage Factor Complex Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Ceramide Biosynthetic Process NAD-dependent Protein Lysine Deacetylase Activity Regulation Of RNA Stability Regulation Of Pro-B Cell Differentiation Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Long-term Neuronal Synaptic Plasticity Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Nuclear Pore Complex Assembly Paraspeckles CRD-mediated MRNA Stabilization
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