DNMT3B and ZBTB18

Number of citations of the paper that reports this interaction (PMID 11350943)
103

Data Source:
HPRD (in vitro)

		DNMT3B	ZBTB18
Gene Name		DNA (cytosine-5-)-methyltransferase 3 beta	zinc finger and BTB domain containing 18
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Intracellular Membrane-bounded Organelle	Nuclear Chromosome Nucleus Nucleoplasm Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Unmethylated CpG Binding Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Response To Ionizing Radiation DNA Methylation On Cytosine Within A CG Sequence Gene Expression Positive Regulation Of Gene Expression Protein Complex Localization DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Response To Drug Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription, DNA-templated Skeletal Muscle Tissue Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Negative Regulation Of Transcription, DNA-templated Neuron Development Homeostasis Of Number Of Cells Regulation Of Cell Division
Pathways		NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		35 interactors: BAZ2A CBX1 CBX3 CBX5 CMTM6 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS ZBTB18	7 interactors: CTBP1 CTBP2 DNMT3A DNMT3B PAK1 POMGNT1 TSN
Entrez ID		1789	10472
HPRD ID		04209	12231
Ensembl ID		ENSG00000088305	ENSG00000179456
Uniprot IDs		Q9UBC3	Q99592
PDB IDs		3FLG 3QKJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process DNA Modification Chromatin Modification Chromosome Organization Chromatin Silencing Chromatin Organization Gene Silencing Nucleobase-containing Compound Metabolic Process DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Metabolic Process Methylation Transcription, DNA-templated Histone H3-K9 Modification Chromatin Remodeling RNA Metabolic Process DNA Methylation On Cytosine Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Histone Modification Peptidyl-lysine Modification Histone H4 Deacetylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Rhythmic Process DNA Packaging Regulation Of Gene Expression By Genetic Imprinting Hypermethylation Of CpG Island C-5 Methylation Of Cytosine	S-adenosylmethioninamine Metabolic Process DNA Methylation On Cytosine Within A CG Sequence C-5 Methylation Of Cytosine S-adenosylhomocysteine Metabolic Process Methylation-dependent Chromatin Silencing DNA Methylation On Cytosine White Fat Cell Differentiation Chromatin Modification Viral Genome Replication Chromatin Organization Regulation Of Gene Expression By Genetic Imprinting Chromatin Silencing Genetic Imprinting Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Chromosome Organization DNA Methylation Cellular Response To Amino Acid Stimulus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Organelle Organization Positive Regulation Of Histone Modification Negative Regulation Of Gene Expression, Epigenetic Cellular Response To Organonitrogen Compound DNA Modification Negative Regulation Of Chromosome Organization Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Silencing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Amino Acid Cellular Nitrogen Compound Metabolic Process Fat Cell Differentiation Regulation Of Histone Modification Negative Regulation Of Cell Proliferation Nitrogen Compound Metabolic Process Cellular Response To Acid Chemical Negative Regulation Of Transcription From RNA Polymerase II Promoter Hypermethylation Of CpG Island Response To Organonitrogen Compound Viral Life Cycle Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Chromosome Organization Regulation Of Gene Expression, Epigenetic Positive Regulation Of Chromatin Binding
Tagcloud ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Difference) ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Intersection) ?