DNMT3B and SMARCA5

Number of citations of the paper that reports this interaction (PubMedID 15120635)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		DNMT3B	SMARCA5
Description		DNA methyltransferase 3 beta	SNF2 related chromatin remodeling ATPase 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Catalytic Complex	Chromatin Condensed Chromosome Fibrillar Center Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Pericentric Heterochromatin Nucleolus CHRAC NURF Complex ACF Complex ISWI-type Complex RSF Complex Site Of Double-strand Break Nuclear Replication Fork WICH Complex NoRC Complex CERF Complex B-WICH Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates	DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nucleosome Binding Histone Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity Histone Octamer Slider Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation	RDNA Heterochromatin Formation Regulation Of DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Transcription By RNA Polymerase I Heterochromatin Formation Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Antiviral Innate Immune Response Negative Regulation Of Mitotic Chromosome Condensation Cellular Response To Leukemia Inhibitory Factor
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Deposition of new CENPA-containing nucleosomes at the centromere
Drugs		Decitabine	Beta-D-Glucose 4-Deoxy-Alpha-D-Glucose
Diseases		Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Nicotine dependence ( 28972577) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)	Appendicular lean mass ( 33097823) Height ( 31562340) Malaria ( 31844061)
Interacting Genes		39 interacting genes: BAZ2A BUD23 CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18	20 interacting genes: BAZ1A BAZ1B BAZ2A CDT1 CHRAC1 CREB1 CTNNB1 DNMT3B GSK3A H3-3A H3C1 H4C16 HDAC2 MAF POLE3 PTEN RAD21 RSF1 SATB1 USP7
Entrez ID		1789	8467
HPRD ID		04209	04538
Ensembl ID		ENSG00000088305	ENSG00000153147
Uniprot IDs		A0A8Q3SIG2 Q9UBC3	O60264
PDB IDs		3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO 6KDA 6KDB 6KDL 6KDP 6KDT 6PA7 6R3E 6U8P 6U8V 6U8W 6U8X 6U90 6U91 7O45 7V0E 7X9D 8EIH 8EII 8EIJ 8EIK 8XEE	6NE3 8V4Y 8V6V 8V7L 9E1L 9E1M 9E1N 9E1O 9E1P 9E1Q 9E1R 9E1U 9E1V 9E1W 9E1X
Enriched GO Terms of Interacting Partners?		Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Pericentric Heterochromatin Constitutive Heterochromatin Formation Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Silencing Complex Negative Regulation Of RNA Metabolic Process Facultative Heterochromatin Formation Epigenetic Programming Of Gene Expression Nucleoplasm Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Negative Regulation Of Metabolic Process DNA Damage Response Cellular Response To Stress Regulation Of Gene Expression RDNA Heterochromatin Formation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Rhythmic Process Chromosome, Centromeric Region Regulation Of Macromolecule Metabolic Process Chromosome Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Chromosome, Telomeric Region Epigenetic Programming In The Zygotic Pronuclei Regulation Of Chromosome Condensation Regulation Of Primary Metabolic Process Chromosomal DNA Methylation Maintenance Following DNA Replication Condensed Nuclear Chromosome Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity NoRC Complex Methylation	Chromatin Remodeling Chromatin Organization Protein-DNA Complex Assembly Nucleosome Assembly Nucleosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process CHRAC Negative Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Pericentric Heterochromatin DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Chromatin Negative Regulation Of Gene Expression, Epigenetic Macromolecule Metabolic Process Cellular Component Assembly Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Fungiform Papilla Formation Protein-containing Complex Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Chromosome Organization Negative Regulation Of Chromosome Condensation Regulation Of DNA Replication Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Hair Follicle Placode Formation Epsilon DNA Polymerase Complex Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Heterochromatin Formation Negative Regulation Of Gene Expression DNA Replication DNA-templated DNA Replication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process
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