DNMT3B and BAZ2A

Number of citations of the paper that reports this interaction (PubMedID 16085498)
0

Data Source:
BioGRID (pull down)

		DNMT3B	BAZ2A
Description		DNA methyltransferase 3 beta	bromodomain adjacent to zinc finger domain 2A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Catalytic Complex	Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus Cytosol Nuclear Speck RDNA Heterochromatin NoRC Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates	RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Binding RNA Binding Protein Binding Zinc Ion Binding Nuclear Receptor Binding Histone Binding Metal Ion Binding Histone H4K16ac Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation	RDNA Heterochromatin Formation RNA Polymerase I Preinitiation Complex Assembly Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase I Heterochromatin Formation
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis	NoRC negatively regulates rRNA expression
Drugs		Decitabine
Diseases		Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Nicotine dependence ( 28972577) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)	Alanine aminotransferase levels ( 33547301) Mean platelet volume ( 22139419 27863252 32888494) Platelet count ( 22139419 32888494) Platelet distribution width ( 32888494)
Interacting Genes		39 interacting genes: BAZ2A BUD23 CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18	8 interacting genes: ADRB2 DNMT1 DNMT3B H4C1 HDAC1 KAT8 SMARCA5 TTF1
Entrez ID		1789	11176
HPRD ID		04209	10417
Ensembl ID		ENSG00000088305	ENSG00000076108
Uniprot IDs		A0A8Q3SIG2 Q9UBC3	F8VU39 J3KPG5 Q9UIF9
PDB IDs		3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO 6KDA 6KDB 6KDL 6KDP 6KDT 6PA7 6R3E 6U8P 6U8V 6U8W 6U8X 6U90 6U91 7O45 7V0E 7X9D 8EIH 8EII 8EIJ 8EIK 8XEE	4LZ2 4Q6F 4QBM 4QF2 5AGQ 5MGJ 5MGK 5MGL 5MGM 5OR8 5T8R 6FAP 6FG6 6FGF 6FGG 6FGH 6FGI 6FGL 6FGV 6FGW 6FHU 6FI0 6FKP 7B7B 7B7G 7B7I 7B82 7BC2 7BL8 7BL9 7BLA 7BLB 7BLC 7BLD 7FHJ 7MWH 7MWI 7MWL 7QVT 7QVU 7QVV 7QWF 7QWU 7QWY 7QX2 7QX9 7QXL 7QYE 7QYO 7QYT 7QYU 7QYV 7QYW 7QZ0 7QZ4 7QZB 7QZC 7QZI 7QZT 7R01 7R0B
Enriched GO Terms of Interacting Partners?		Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Pericentric Heterochromatin Constitutive Heterochromatin Formation Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Silencing Complex Negative Regulation Of RNA Metabolic Process Facultative Heterochromatin Formation Epigenetic Programming Of Gene Expression Nucleoplasm Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Negative Regulation Of Metabolic Process DNA Damage Response Cellular Response To Stress Regulation Of Gene Expression RDNA Heterochromatin Formation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Rhythmic Process Chromosome, Centromeric Region Regulation Of Macromolecule Metabolic Process Chromosome Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Chromosome, Telomeric Region Epigenetic Programming In The Zygotic Pronuclei Regulation Of Chromosome Condensation Regulation Of Primary Metabolic Process Chromosomal DNA Methylation Maintenance Following DNA Replication Condensed Nuclear Chromosome Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity NoRC Complex Methylation	Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic DNA-methyltransferase Activity Heterochromatin Formation DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Organization DNA (cytosine-5-)-methyltransferase Activity Constitutive Heterochromatin Formation Promoter-specific Chromatin Binding Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Developmental Process Chromatin Binding DNA Binding Pericentric Heterochromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Heterochromatin Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Muscle Cell Differentiation DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates DNA-templated Transcription Initiation DNA-templated Transcription Enzyme Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Beta2-adrenergic Receptor Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Positive Regulation Of Smooth Muscle Cell Proliferation Chromosomal DNA Methylation Maintenance Following DNA Replication Krueppel-associated Box Domain Binding WICH Complex Negative Regulation Of Mitotic Chromosome Condensation ISWI-type Complex NoRC Complex Histone Octamer Slider Activity
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