DNMT3B and RPS10

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		DNMT3B	RPS10
Description		DNA methyltransferase 3 beta	ribosomal protein S10
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Catalytic Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Synapse Ribonucleoprotein Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation	Cytoplasmic Translation Translation
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Decitabine
Diseases		Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions	Diamond-Blackfan anemia (DBA)
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Nicotine dependence ( 28972577) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)	Adult body size ( 32376654) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Estimated glomerular filtration rate ( 30604766 31015462) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494)
Interacting Genes		39 interacting genes: BAZ2A BUD23 CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18	19 interacting genes: APP DMPK DNMT3B DUX4 DVL3 EED FBXO25 HAP1 HIP1 KAT7 MKRN1 PFN2 PTTG1 RNF10 SYK TCF25 WIZ XRCC6 ZNF598
Entrez ID		1789	6204
HPRD ID		04209	04697
Ensembl ID		ENSG00000088305	ENSG00000124614
Uniprot IDs		A0A8Q3SIG2 Q9UBC3	P46783
PDB IDs		3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO 6KDA 6KDB 6KDL 6KDP 6KDT 6PA7 6R3E 6U8P 6U8V 6U8W 6U8X 6U90 6U91 7O45 7V0E 7X9D 8EIH 8EII 8EIJ 8EIK 8XEE	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7QVP 7R4X 7TQL 7XNX 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Pericentric Heterochromatin Constitutive Heterochromatin Formation Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Silencing Complex Negative Regulation Of RNA Metabolic Process Facultative Heterochromatin Formation Epigenetic Programming Of Gene Expression Nucleoplasm Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Negative Regulation Of Metabolic Process DNA Damage Response Cellular Response To Stress Regulation Of Gene Expression RDNA Heterochromatin Formation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Rhythmic Process Chromosome, Centromeric Region Regulation Of Macromolecule Metabolic Process Chromosome Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Chromosome, Telomeric Region Epigenetic Programming In The Zygotic Pronuclei Regulation Of Chromosome Condensation Regulation Of Primary Metabolic Process Chromosomal DNA Methylation Maintenance Following DNA Replication Condensed Nuclear Chromosome Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity NoRC Complex Methylation	Presynapse Regulation Of Superoxide Anion Generation Regulation Of Primary Metabolic Process Modulation Of Chemical Synaptic Transmission Regulation Of Macromolecule Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Cytosol Regulation Of Receptor Internalization Nucleus Positive Regulation Of Superoxide Anion Generation Protein Stabilization Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nervous System Process Regulation Of Receptor-mediated Endocytosis Molecular Function Activator Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Amyloid-beta Complex Signaling Receptor Binding Growth Cone Lamellipodium Regulation Of Cell Differentiation Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Calcium-mediated Signaling Amylin Binding Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Regulation Of Superoxide Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Receptor Internalization Cytoplasm Frizzled Binding Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Regulation Of Protein Stability Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of ERBB Signaling Pathway Interleukin-15 Receptor Binding Positive Regulation Of Interleukin-3 Production Positive Regulation Of Neurotrophin Production Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Positive Regulation Of DNA Replication Rescue Of Stalled Ribosome Ribosome Disassembly
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