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DNMT3B and SUMO1
Number of citations of the paper that reports this interaction (PubMedID
11735126
)
0
Data Source:
BioGRID
(pull down)
HPRD
(in vivo, two hybrid)
DNMT3B
SUMO1
Description
DNA methyltransferase 3 beta
small ubiquitin like modifier 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Catalytic Complex
XY Body
Nucleus
Nuclear Pore
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Voltage-gated Potassium Channel Complex
Membrane
Nuclear Body
PML Body
Nuclear Speck
Nuclear Membrane
Nuclear Stress Granule
Glutamatergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
Molecular Function
DNA Binding
Transcription Corepressor Activity
DNA (cytosine-5-)-methyltransferase Activity
Protein Binding
Methyltransferase Activity
Zinc Ion Binding
DNA-methyltransferase Activity
Transferase Activity
Metal Ion Binding
DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
RNA Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Enzyme Binding
Protein Tag Activity
Ubiquitin Protein Ligase Binding
Small Protein Activating Enzyme Binding
Ubiquitin-like Protein Ligase Binding
Transporter Activator Activity
Ubiquitin-specific Protease Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Methylation
Negative Regulation Of Transcription By RNA Polymerase II
DNA Repair
Regulation Of DNA-templated Transcription
Protein Sumoylation
PML Body Organization
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Protein Stability
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Cellular Response To Heat
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Action Potential
Negative Regulation Of DNA-templated Transcription
Protein Stabilization
Roof Of Mouth Development
Cellular Response To Cadmium Ion
Regulation Of Cardiac Muscle Cell Contraction
Protein Localization To Nuclear Pore
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Regulation Of Calcium Ion Transmembrane Transport
Pathways
PRC2 methylates histones and DNA
NoRC negatively regulates rRNA expression
SUMOylation of DNA methylation proteins
DNA methylation
Defective pyroptosis
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Formation of Incision Complex in GG-NER
Regulation of IFNG signaling
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
SUMOylation of nuclear envelope proteins
PKR-mediated signaling
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Decitabine
Diseases
Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS
Appendicular lean mass (
33097823
)
Brain morphology (MOSTest) (
32665545
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Inflammatory bowel disease (
23128233
)
Iron status biomarkers (iron levels) (
28334935
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Nicotine dependence (
28972577
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Prostate cancer (
29892016
)
Pulse pressure (
27841878
30578418
)
Total cholesterol levels (
30275531
)
Interacting Genes
39 interacting genes:
BAZ2A
BUD23
CBX1
CBX3
CBX5
CMTM6
CUL4B
DDB1
DNMT1
DNMT3A
DNMT3L
DUSP23
EED
EZH2
H3C1
HDAC1
HDAC2
HELLS
KIF4A
MAP1LC3B
MBD4
NCAPG
NEDD8
NRIP1
PAM16
PCYT2
PLEKHJ1
RPS10
SMARCA5
SMC2
SPI1
SUMO1
SUV39H1
TDG
TSC22D1
UBE2I
UBE2W
WARS1
ZBTB18
154 interacting genes:
AR
ARK2N
ARRB2
ATF2
ATXN1
ATXN3
ATXN7
AXIN1
BIRC3
BLM
BRCA1
BTBD3
C11orf65
CANX
CARD9
CASP2
CASP8
CCR2
CDK6
CEBPA
CHAF1A
CHD3
CREBBP
DAXX
DEUP1
DNM1
DNMT3B
DTX2
EDARADD
EGLN3
EIF2AK2
ERCC6
ETV6
FAF1
FAM118B
FAS
FASLG
FBF1
FOS
FOXM1
GMCL1
HDAC4
HDAC9
HGS
HIF1A
HIPK2
HIPK3
HNRNPC
HNRNPK
HSF1
HTT
IKZF3
IRAK1
ISG15
JUN
MAPK1IP1L
MDM2
MEF2A
MITF
MRE11
MRTFA
MSX1
MTOR
MUL1
MYB
NCOA1
NCOA2
NCOA3
NCOR2
NFE2L2
NFKBIA
NIN
NR3C1
NR3C2
PARK7
PAX6
PCNA
PDGFC
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PKM
PLAGL1
PML
PPM1J
PRKN
PROP1
PSIP1
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RHOXF2
RNF111
RNF167
RNF4
RPS3
SALL1
SATB1
SENP1
SENP2
SENP6
SETX
SLC2A1
SMARCAD1
SOX10
SOX2
SOX6
SP100
SP3
SPOP
SREBF1
SREBF2
SUMO1P1
TDG
TDP2
TFCP2
TMIE
TNFRSF1A
TOE1
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP73
TRAF2
TRAF4
TRAF5
TRIM24
TRPS1
TSC22D3
UBA2
UBE2I
USP25
USPL1
WRN
ZBED1
ZBTB16
ZBTB2
ZBTB26
ZBTB6
ZCCHC12
ZCCHC7
ZFP42
ZHX1
ZMYM2
ZMYM3
ZMYM5
ZNF451
Entrez ID
1789
7341
HPRD ID
04209
03554
Ensembl ID
ENSG00000088305
ENSG00000116030
Uniprot IDs
A0A8Q3SIG2
Q9UBC3
B8ZZN6
B9A032
P63165
PDB IDs
3FLG
3QKJ
5CIU
5NR3
5NRR
5NRS
5NRV
5NV0
5NV2
5NV7
5NVO
6KDA
6KDB
6KDL
6KDP
6KDT
6PA7
6R3E
6U8P
6U8V
6U8W
6U8X
6U90
6U91
7O45
7V0E
7X9D
8EIH
8EII
8EIJ
8EIK
8XEE
1A5R
1TGZ
1WYW
1Y8R
1Z5S
2ASQ
2BF8
2G4D
2IO2
2IY0
2IY1
2KQS
2LAS
2MW5
2N1A
2N1V
2PE6
2UYZ
2VRR
3KYC
3KYD
3RZW
3UIP
4WJN
4WJO
4WJP
4WJQ
5AEK
5B7A
5ELJ
5GHD
6EOP
6EOT
6J4I
6JXU
6JXV
6K5T
6TRW
6UYO
6UYP
6UYQ
6UYR
6UYS
6UYT
6UYU
6UYV
6UYX
6UYY
6UYZ
6V7P
6V7Q
6V7R
6V7S
6WW3
6XOG
6XOH
6XOI
8DJH
8DJI
8ODR
9B62
Enriched GO Terms of Interacting Partners
?
Epigenetic Regulation Of Gene Expression
Heterochromatin Formation
Negative Regulation Of Gene Expression, Epigenetic
Chromatin Remodeling
Heterochromatin
Chromatin Organization
DNA Methylation-dependent Constitutive Heterochromatin Formation
Pericentric Heterochromatin
Constitutive Heterochromatin Formation
Chromatin Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Chromatin Silencing Complex
Negative Regulation Of RNA Metabolic Process
Facultative Heterochromatin Formation
Epigenetic Programming Of Gene Expression
Nucleoplasm
Nucleus
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
ESC/E(Z) Complex
Negative Regulation Of Metabolic Process
DNA Damage Response
Cellular Response To Stress
Regulation Of Gene Expression
RDNA Heterochromatin Formation
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Rhythmic Process
Chromosome, Centromeric Region
Regulation Of Macromolecule Metabolic Process
Chromosome
Regulation Of Nucleobase-containing Compound Metabolic Process
Histone Deacetylase Complex
Chromosome, Telomeric Region
Epigenetic Programming In The Zygotic Pronuclei
Regulation Of Chromosome Condensation
Regulation Of Primary Metabolic Process
Chromosomal DNA Methylation Maintenance Following DNA Replication
Condensed Nuclear Chromosome
Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity
NoRC Complex
Methylation
Regulation Of RNA Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
PML Body
Nucleoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
DNA Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Protein Sumoylation
Positive Regulation Of DNA-templated Transcription
Cellular Response To Stress
Positive Regulation Of RNA Metabolic Process
Chromatin
Positive Regulation Of Transcription By RNA Polymerase II
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Chromatin Binding
DNA Damage Response
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Macromolecule Metabolic Process
Response To Stress
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Nuclear Body
Protein-containing Complex
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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