HMGA2 and PRMT6

Number of citations of the paper that reports this interaction (PMID 16293633)
22

Data Source:
BioGRID (enzymatic study, far western blotting)

		HMGA2	PRMT6
Gene Name		high mobility group AT-hook 2	protein arginine methyltransferase 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	Regulatory Region DNA Binding Transcription Factor Binding Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding AT DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity DNA-dependent Protein Kinase Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity C2H2 Zinc Finger Domain Binding	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Catabolic Process, Endonucleolytic Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mitotic Nuclear Division Mitotic G2 DNA Damage Checkpoint Multicellular Organismal Development Response To Virus Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Chromosome Condensation Chromosome Breakage Heterochromatin Assembly Histone H2A-S139 Phosphorylation Senescence-associated Heterochromatin Focus Assembly Endodermal Cell Differentiation Chondrocyte Proliferation Regulation Of Growth DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation By Host Of Viral Transcription Fat Cell Differentiation Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Mesodermal Cell Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Cell Division Positive Regulation Of Cell Cycle Arrest Oncogene-induced Cell Senescence Regulation Of Stem Cell Maintenance Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Cellular Response To X-ray Positive Regulation Of Cellular Senescence Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cellular Response To Drug	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Cellular Senescence	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Aortic root size ( 19584346) Birth weight ( 23202124) Brain structure ( 22504417) Head circumference (infant) ( 22504419) Height ( 21998595 20881960 22021425 19343178 23563607 18391950 18391951 18391952 20397748 17767157) Permanent tooth development ( 21931568) Polycystic ovary syndrome ( 22885925) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Type 2 diabetes ( 20581827) Type 2 diabetes nephropathy ( 21150874)	Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		19 interactors: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP XRCC6	91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		8091	55170
HPRD ID		02827	10505
Ensembl ID		ENSG00000149948	ENSG00000198890
Uniprot IDs		F5H2A4 P52926	Q96LA8
PDB IDs			4HC4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Transcription, DNA-templated Regulation Of RNA Metabolic Process Cell Cycle Process RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Cell Cycle Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Mitotic Cell Cycle Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Type I Interferon Production Regulation Of Cell Cycle Process Response To Stress	Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation
Tagcloud ?		accumulated approaches basic benign demonstrates encoding hook2 initiating leiomyoma leiomyomas limits mesenchymal mobility myometrial opens origin possibilities putative rearrangements side sp stem toward transformation truncated understand uterine work	bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Difference) ?		accumulated approaches basic benign demonstrates encoding hook2 initiating leiomyoma leiomyomas limits mesenchymal mobility myometrial opens origin possibilities putative rearrangements side sp stem toward transformation truncated understand uterine work	bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Intersection) ?