HMGA2 and SYNCRIP

Number of citations of the paper that reports this interaction (PMID 18850631)
2

Data Source:
BioGRID (far western blotting)

		HMGA2	SYNCRIP
Gene Name		high mobility group AT-hook 2	synaptotagmin binding, cytoplasmic RNA interacting protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex	Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Ribonucleoprotein Complex CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Histone Pre-mRNA 3'end Processing Complex GAIT Complex
	Molecular Function	Regulatory Region DNA Binding Transcription Factor Binding Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding AT DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity DNA-dependent Protein Kinase Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity C2H2 Zinc Finger Domain Binding	Nucleotide Binding RNA Binding Protein Binding Poly(A) Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Catabolic Process, Endonucleolytic Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mitotic Nuclear Division Mitotic G2 DNA Damage Checkpoint Multicellular Organismal Development Response To Virus Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Chromosome Condensation Chromosome Breakage Heterochromatin Assembly Histone H2A-S139 Phosphorylation Senescence-associated Heterochromatin Focus Assembly Endodermal Cell Differentiation Chondrocyte Proliferation Regulation Of Growth DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation By Host Of Viral Transcription Fat Cell Differentiation Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Mesodermal Cell Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Cell Division Positive Regulation Of Cell Cycle Arrest Oncogene-induced Cell Senescence Regulation Of Stem Cell Maintenance Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Cellular Response To X-ray Positive Regulation Of Cellular Senescence Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cellular Response To Drug	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing RNA Splicing Viral Process Negative Regulation Of Translation CRD-mediated MRNA Stabilization Cellular Response To Interferon-gamma
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Cellular Senescence
Drugs
Diseases
GWAS		Aortic root size ( 19584346) Birth weight ( 23202124) Brain structure ( 22504417) Head circumference (infant) ( 22504419) Height ( 21998595 20881960 22021425 19343178 23563607 18391950 18391951 18391952 20397748 17767157) Permanent tooth development ( 21931568) Polycystic ovary syndrome ( 22885925) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Type 2 diabetes ( 20581827) Type 2 diabetes nephropathy ( 21150874)
Protein-Protein Interactions		19 interactors: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP XRCC6	31 interactors: A1CF APOBEC1 APP CSDE1 EPRS GRB2 HABP4 HMGA1 HMGA2 HNRNPD HNRNPK IL7R INSR IVNS1ABP KLHL3 NUPR1 PABPC1 PCSK7 PLCG1 PRMT1 PRMT8 PTPN11 SMN1 SYT1 SYT11 SYT2 SYT3 SYT4 SYT7 SYT8 SYT9
Entrez ID		8091	10492
HPRD ID		02827	06734
Ensembl ID		ENSG00000149948	ENSG00000135316
Uniprot IDs		F5H2A4 P52926	B7Z645 O60506 Q59GL1
PDB IDs			2DGU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Transcription, DNA-templated Regulation Of RNA Metabolic Process Cell Cycle Process RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Cell Cycle Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Mitotic Cell Cycle Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Type I Interferon Production Regulation Of Cell Cycle Process Response To Stress	Exocytosis MRNA Metabolic Process RNA Processing Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis MRNA Processing Cytidine To Uridine Editing Oncogene-induced Cell Senescence Secretion By Cell Positive Regulation Of Transport Senescence-associated Heterochromatin Focus Assembly Regulation Of Vesicle-mediated Transport Positive Regulation Of Cellular Senescence Regulation Of Vesicle Fusion Secretion Regulation Of Secretion RNA Metabolic Process Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of Chromatin Silencing Base Conversion Or Substitution Editing Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Cellular Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Cell Aging Vesicle-mediated Transport Viral Process Positive Regulation Of Exocytosis RNA Splicing Regulation Of Growth Hormone Secretion Wound Healing Regulation Of Gene Expression Heterochromatin Assembly Positive Regulation Of Protein Metabolic Process Peptidyl-arginine N-methylation Histone H4-R3 Methylation Positive Regulation Of Metabolic Process Cellular Response To Insulin Stimulus Gene Expression Regulation Of Peptide Hormone Secretion Heterochromatin Organization Blood Coagulation Reproductive Process Hemostasis MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Response To Wounding
Tagcloud ?		accumulated approaches basic benign demonstrates encoding hook2 initiating leiomyoma leiomyomas limits mesenchymal mobility myometrial opens origin possibilities putative rearrangements side sp stem toward transformation truncated understand uterine work	autonomy back bmp bottom connections correct explained genetically glass highlight influences maintaining modulates morphogenic motoneuron output partly plasticity postsynaptic presynaptic probability proper retrograde signals synapse synaptic transmission unexpected vesicle
Tagcloud (Difference) ?		accumulated approaches basic benign demonstrates encoding hook2 initiating leiomyoma leiomyomas limits mesenchymal mobility myometrial opens origin possibilities putative rearrangements side sp stem toward transformation truncated understand uterine work	autonomy back bmp bottom connections correct explained genetically glass highlight influences maintaining modulates morphogenic motoneuron output partly plasticity postsynaptic presynaptic probability proper retrograde signals synapse synaptic transmission unexpected vesicle
Tagcloud (Intersection) ?