HMGA2

Name	high mobility group AT-hook 2
Structure	No pdb structure
Interactors	21 interactors: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 KAT2B MDM2 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP TP53
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Nucleic Acid Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding DNA Binding, Bending Enzyme Binding Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Regulation Of DNA-templated Transcription Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Response To Virus Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Cell Proliferation In Forebrain Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Chromosome Condensation Adrenal Gland Development Heterochromatin Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Multicellular Organism Growth Intracellular Signal Transduction Endodermal Cell Differentiation Chondrocyte Proliferation Positive Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Host-mediated Suppression Of Viral Transcription Fat Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Mesodermal Cell Differentiation Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Cell Division Regulation Of Growth Hormone Secretion Lung Epithelium Development Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Adipose Tissue Development Fat Pad Development Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Protein Serine/threonine Kinase Activity Stem Cell Proliferation Regulation Of Peptide Hormone Secretion Oncogene-induced Cell Senescence Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
GWAS	Adverse response to drug ( 30420678 ) Aortic root size ( 19584346 ) Appendicular lean mass ( 33097823 ) Axial length ( 24144296 ) Birth length ( 25281659 ) Birth weight ( 31043758 27680694 23202124 ) Body size at age 10 ( 32376654 ) Brain structure ( 22504417 ) Childhood body mass index ( 33045005 ) Chin dimples ( 27182965 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Cortical surface area (global PC1) ( 32198502 ) Cortical volume ( 32963231 ) Fasting insulin ( 34059833 ) Haemorrhoidal disease ( 33888516 ) Head circumference (infant) ( 22504419 ) Heart rate response to exercise ( 29769521 ) Heel bone mineral density ( 30598549 ) Height ( 25282103 18391952 28552196 20881960 18391951 18391950 25429064 19343178 21998595 20397748 23563607 22021425 31562340 17767157 ) Hip circumference ( 25673412 ) Hip circumference adjusted for BMI ( 25673412 34021172 ) Hip index ( 34021172 ) Infant length ( 25281659 ) Late-onset Alzheimer's disease ( 27770636 ) Medication use (drugs used in diabetes) ( 31015401 ) Neutrophil count ( 32888494 ) Offspring birth weight ( 31043758 ) Permanent tooth development ( 21931568 ) Plateletcrit ( 32888494 ) Polycystic ovary syndrome ( 22885925 ) Primary tooth development (number of teeth) ( 20195514 23704328 ) Primary tooth development (time to first tooth eruption) ( 23704328 20195514 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 31928498 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 32499647 28869590 20581827 30297969 30054458 29358691 26961502 25102180 24509480 22885922 ) Type 2 diabetes nephropathy ( 21150874 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 ) Youthful appearance (self-reported) ( 32339537 )
Entrez ID	8091
HPRD ID	02827
Ensembl ID	ENSG00000149948
Uniprot IDs	F5H2A4 F5H6H0 P52926 Q1M183
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Organization Nucleus Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Remodeling Regulation Of Cell Differentiation Ubiquitin Protein Ligase Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Peptide Hormone DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Process DNA Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Response To Stress Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Response To Oxidative Stress