HMGA2 and NFKB1

Number of citations of the paper that reports this interaction (PubMedID 12693954)
0

Data Source:
HPRD (in vitro)

		HMGA2	NFKB1
Description		high mobility group AT-hook 2	nuclear factor kappa B subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex	Chromatin Extracellular Region Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol I-kappaB/NF-kappaB Complex Secretory Granule Lumen NF-kappaB P50/p65 Complex Specific Granule Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding Nucleic Acid Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding DNA Binding, Bending Enzyme Binding Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Identical Protein Binding Actinin Binding Sequence-specific DNA Binding Protein Sequestering Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Regulation Of DNA-templated Transcription Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Response To Virus Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Cell Proliferation In Forebrain Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Chromosome Condensation Adrenal Gland Development Heterochromatin Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Multicellular Organism Growth Intracellular Signal Transduction Endodermal Cell Differentiation Chondrocyte Proliferation Positive Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Host-mediated Suppression Of Viral Transcription Fat Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Mesodermal Cell Differentiation Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Cell Division Regulation Of Growth Hormone Secretion Lung Epithelium Development Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Adipose Tissue Development Fat Pad Development Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Protein Serine/threonine Kinase Activity Stem Cell Proliferation Regulation Of Peptide Hormone Secretion Oncogene-induced Cell Senescence Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Negative Regulation Of Cytokine Production Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Gene Expression Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipid Storage Negative Regulation Of Vitamin D Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Interleukin-12 Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Muscle Stretch Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response B Cell Receptor Signaling Pathway Mammary Gland Involution Positive Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To DsRNA Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Interleukin-17 Cellular Response To Virus Antibacterial Innate Immune Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Angiotensin Positive Regulation Of MiRNA Metabolic Process
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1-dependent IKK and NF-kappa-B activation Interleukin-1 processing IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Neutrophil degranulation The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation HCMV Early Events Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses Regulation of NFE2L2 gene expression Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription
Drugs			Sulfasalazine Donepezil Pseudoephedrine Pranlukast Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Triflusal Terpinen-4-ol Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Adverse response to drug ( 30420678) Aortic root size ( 19584346) Appendicular lean mass ( 33097823) Axial length ( 24144296) Birth length ( 25281659) Birth weight ( 31043758 27680694 23202124) Body size at age 10 ( 32376654) Brain structure ( 22504417) Childhood body mass index ( 33045005) Chin dimples ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cortical surface area (global PC1) ( 32198502) Cortical volume ( 32963231) Fasting insulin ( 34059833) Haemorrhoidal disease ( 33888516) Head circumference (infant) ( 22504419) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 25282103 18391952 28552196 20881960 18391951 18391950 25429064 19343178 21998595 20397748 23563607 22021425 31562340 17767157) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Infant length ( 25281659) Late-onset Alzheimer's disease ( 27770636) Medication use (drugs used in diabetes) ( 31015401) Neutrophil count ( 32888494) Offspring birth weight ( 31043758) Permanent tooth development ( 21931568) Plateletcrit ( 32888494) Polycystic ovary syndrome ( 22885925) Primary tooth development (number of teeth) ( 20195514 23704328) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 31928498) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647 28869590 20581827 30297969 30054458 29358691 26961502 25102180 24509480 22885922) Type 2 diabetes nephropathy ( 21150874) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Youthful appearance (self-reported) ( 32339537)	Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Basophil percentage of white cells ( 32888494) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Copper levels ( 26025379) Creatinine levels ( 29124443) Crohn's disease ( 28067908) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Estimated glomerular filtration rate ( 29124443 30604766) Glomerular filtration rate (creatinine) ( 26831199) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Membranous nephropathy ( 32231244) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 21833088) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483 23000144 26394269 28062665 21399635 30643196) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 27992413) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia (treatment resistant) ( 22479419) Serum total protein levels ( 29403010) Serum uric acid levels ( 29124443) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 31672989 30247649) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 23128233) White blood cell count ( 32888494)
Interacting Genes		21 interacting genes: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 KAT2B MDM2 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP TP53	106 interacting genes: ABCC2 APBB2 AR ATF3 BARD1 BCL3 BRCA1 BTRC CDK9 CEBPB CFLAR CHUK COPB2 COPS5 CTNNB1 DNMT3L E2F1 ECSIT ELF1 ELF3 ESR1 ETS1 FBXO7 FBXW11 FOS G3BP2 GLUL GSK3B HDAC1 HMGA1 HMGA2 HMGB1 HSPA4 IKBKB IKBKG IL2RA IRF1 IRF2 IRF8 IRF9 ITGB3BP KAT5 KLF5 KPNA3 LYL1 MAP3K8 MEN1 MTPN NCOA1 NCOA6 NCOR2 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIZ NFRKB NKRF NOTCH1 NR3C1 NR4A1 PALS2 PARP1 PCBD1 PDCD11 PELP1 PLD3 PML PPARG PPP4C PRKACA PSMD10 REL RELA RELB RGS14 RIPK1 RPS3 RSF1 RXRA SERPINA3 SF1 SIN3A SP1 SPAG9 SPI1 SPPL2A SRF STAT3 STAT6 TAB2 TFAP2A TNFSF11 TNIP2 TP53BP1 TP53BP2 TRIP4 TSC22D3 TXN UBE2D2 UBE2D3 UBE2K UNC5CL YWHAQ YY1 ZBTB9
Entrez ID		8091	4790
HPRD ID		02827	01238
Ensembl ID		ENSG00000149948	ENSG00000109320
Uniprot IDs		F5H2A4 F5H6H0 P52926 Q1M183	P19838
PDB IDs			1MDI 1MDJ 1MDK 1NFI 1SVC 2DBF 2O61 3GUT 7LEQ 7LET 7LF4 7LFC 7RG4 7RG5 8TQD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Organization Nucleus Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Remodeling Regulation Of Cell Differentiation Ubiquitin Protein Ligase Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Peptide Hormone DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Process DNA Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Response To Stress Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Response To Oxidative Stress	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleus Chromatin Transcription Cis-regulatory Region Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Response To Stress RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Regulation Of Apoptotic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Programmed Cell Death Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Intracellular Signal Transduction Response To Cytokine Response To Peptide Sequence-specific DNA Binding Regulation Of Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Non-canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Developmental Process Transcription Regulator Complex
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