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FLAD1 and TK1
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
FLAD1
TK1
Gene Name
flavin adenine dinucleotide synthetase 1
thymidine kinase 1, soluble
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Mitochondrial Matrix
Cytosol
Plasma Membrane
Cytosol
Molecular Function
FMN Adenylyltransferase Activity
ATP Binding
Thymidine Kinase Activity
ATP Binding
Zinc Ion Binding
Nucleoside Kinase Activity
Identical Protein Binding
Biological Process
FAD Biosynthetic Process
Vitamin Metabolic Process
Water-soluble Vitamin Metabolic Process
Riboflavin Metabolic Process
Mo-molybdopterin Cofactor Biosynthetic Process
Small Molecule Metabolic Process
Liver Development
Nucleobase-containing Compound Metabolic Process
Pyrimidine Nucleobase Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Nucleotide Biosynthetic Process
Response To Toxic Substance
Skeletal Muscle Cell Proliferation
Phosphorylation
Response To Nutrient Levels
Pyrimidine Nucleoside Salvage
Small Molecule Metabolic Process
Thymidine Metabolic Process
Response To Copper Ion
Digestive Tract Development
Protein Homotetramerization
Response To Cortisol
Nucleobase-containing Small Molecule Metabolic Process
Fetal Process Involved In Parturition
DNA Biosynthetic Process
Pathways
Metabolism of vitamins and cofactors
Defective CD320 causes methylmalonic aciduria
Defective GIF causes intrinsic factor deficiency
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
Defective HLCS causes multiple carboxylase deficiency
Defective MMAB causes methylmalonic aciduria type cblB
Defective BTD causes biotidinase deficiency
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defective MMAA causes methylmalonic aciduria type cblA
Vitamin B2 (riboflavin) metabolism
Defective CUBN causes hereditary megaloblastic anemia 1
Defective AMN causes hereditary megaloblastic anemia 1
Metabolism of water-soluble vitamins and cofactors
Defective MUT causes methylmalonic aciduria mut type
Defects in biotin (Btn) metabolism
Defective TCN2 causes hereditary megaloblastic anemia
Defects in vitamin and cofactor metabolism
Defects in cobalamin (B12) metabolism
Pyrimidine salvage reactions
Pyrimidine metabolism
Metabolism of nucleotides
Drugs
Dithioerythritol
Thymidine-5\'-Triphosphate
Diseases
GWAS
Prostate cancer (
23535732
)
Protein-Protein Interactions
13 interactors:
ANXA7
CDKN1A
GEMIN4
GRB7
NUDT21
PRTFDC1
RCC1
REL
SDCBP
SMN1
TCF4
TK1
TRIM23
159 interactors:
A1BG
A2M
AAMP
ABHD4
ACTB
ACTL6B
ACTR1B
ADAMTS10
ADD1
AGAP1
ALAS1
ALB
APLP1
APP
ARFGAP1
ASNA1
ATG16L2
ATP5B
ATP6V1A
ATXN3
BAG6
C14orf1
C19orf60
CARHSP1
CCDC115
CCDC90B
CDC20
CDK1
CDK4
CDKN1A
CENPB
CHGB
CLEC3B
COL11A2
COL4A2
COL4A5
COPS6
CPNE6
CPSF3L
CRIP2
CRMP1
CSAD
DACT1
DALRD3
DCAF13
DDAH2
DEAF1
DMPK
DOCK7
DRAP1
DUS2
DYNC1I1
EEF1A1
EIF3G
EIF4A2
EIF6
EXT2
EZH2
F13A1
FAF1
FAM20C
FBN3
FGB
FLAD1
FST
FZR1
GAPDH
GDF9
GDI1
GLB1
GPCPD1
HADHB
HERC3
HMGXB3
HSPBAP1
IER3IP1
IGHM
IMMT
INPP5K
ITSN1
JADE1
JMJD1C
KDM6B
KIF21B
KIF5A
KLHL23
KLHL5
KMT2B
LOC148413
LRIF1
MAGEA4
MAST2
MED31
METTL23
MKI67
MPP1
MPPED1
MRFAP1
MRPL37
MSH2
NEUROD2
NGFR
NKIRAS2
NMT2
NRBP1
ODC1
PAAF1
PDE4DIP
PKM
PLD3
PLXNA3
PPP4C
PROC
PSME1
PTPN4
PTPRK
QARS
RBBP4
RBM48
RPA1
RPL13
RPS2
RUVBL1
RXRA
SDF4
SEMA5B
SEPT6
SETDB1
SEZ6L2
SMC5
SNX1
SP110
SULT1A3
SUMO3
TAF1C
TCTEX1D2
THOC3
TIAM2
TLE1
TMSB4X
TP53
TRIM46
TRMT2A
TSC2
TTC38
TUBA1A
TUBB2A
TUBB3
TYK2
UNC119
UPF2
USP4
WDR18
WDR60
WDR73
WIZ
ZBTB16
ZNF431
ZXDC
Entrez ID
80308
7083
HPRD ID
17887
01771
Ensembl ID
ENSG00000160688
ENSG00000167900
Uniprot IDs
Q8NFF5
P04183
PDB IDs
1W4R
1XBT
2ORV
2WVJ
Enriched GO Terms of Interacting Partners
?
Cellular Component Assembly
Digestive Tract Development
Digestive System Development
Ribonucleoprotein Complex Assembly
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Cellular Macromolecular Complex Assembly
Spliceosomal SnRNP Assembly
Negative Regulation Of Gene Expression
Ribonucleoprotein Complex Biogenesis
Fetal Process Involved In Parturition
RNA Splicing
Skeletal Muscle Cell Proliferation
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
MRNA Processing
Protein Tetramerization
Response To Extracellular Stimulus
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Regulation Of Cellular Component Organization
Positive Regulation Of Extracellular Vesicular Exosome Assembly
Maintenance Of DNA Repeat Elements
MRNA Metabolic Process
Cell Cycle Arrest
Intestinal Epithelial Cell Maturation
RNA Processing
Positive Regulation Of Signal Transduction
Response To Glucocorticoid
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Extracellular Vesicular Exosome Assembly
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Response To Cortisol
Thymidine Metabolic Process
Embryonic Hindgut Morphogenesis
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Response To Corticosteroid
Small GTPase Mediated Signal Transduction
Embryonic Genitalia Morphogenesis
Response To Toxic Substance
Positive Regulation Of Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Cellular Response To UV-B
Myoblast Fate Commitment
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Ran GTPase Activity
Tube Development
Secretory Granule Localization
Pyrimidine Nucleoside Salvage
Pyrimidine-containing Compound Salvage
Cellular Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Protein Metabolic Process
Developmental Process
Anatomical Structure Development
System Development
Regulation Of Cellular Protein Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Multicellular Organismal Development
Cellular Localization
Metabolic Process
Regulation Of Metabolic Process
Organelle Organization
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Protein Metabolic Process
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Catabolic Process
RNA Metabolic Process
Negative Regulation Of Cell Cycle
Posttranscriptional Regulation Of Gene Expression
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Cell Differentiation
Platelet Degranulation
Gene Expression
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Negative Regulation Of Mitotic Cell Cycle
Cellular Process
Biosynthetic Process
Regulation Of Cell Cycle
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cell Cycle Process
Mitotic Cell Cycle Process
Axon Guidance
Chromatin Organization
Viral Process
Programmed Cell Death
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Chromosome Organization
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cellular Response To Organic Substance
Mitotic Cell Cycle
Cellular Response To Growth Factor Stimulus
Tagcloud
?
american
artiodactyla
assigned
block
blot
cattle
chr
conservative
conserved
cow
electrophoresis
erbb2
hybrid
hybridization
localization
localized
means
mink
nf1
pepa
pig
prkca
rara
representatives
sheep
southern
swine
synteny
umph2
Tagcloud (Difference)
?
american
artiodactyla
assigned
block
blot
cattle
chr
conservative
conserved
cow
electrophoresis
erbb2
hybrid
hybridization
localization
localized
means
mink
nf1
pepa
pig
prkca
rara
representatives
sheep
southern
swine
synteny
umph2
Tagcloud (Intersection)
?