FLAD1 and GEMIN4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FLAD1	GEMIN4
Gene Name		flavin adenine dinucleotide synthetase 1	gem (nuclear organelle) associated protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Cytosol Plasma Membrane	Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Vesicular Exosome Gemini Of Coiled Bodies
	Molecular Function	FMN Adenylyltransferase Activity ATP Binding	Protein Binding
	Biological Process	FAD Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Riboflavin Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Small Molecule Metabolic Process	Spliceosomal SnRNP Assembly RRNA Processing Gene Expression NcRNA Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Vitamin B2 (riboflavin) metabolism Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism	snRNP Assembly Metabolism of non-coding RNA
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Prostate cancer ( 23535732)
Protein-Protein Interactions		13 interactors: ANXA7 CDKN1A GEMIN4 GRB7 NUDT21 PRTFDC1 RCC1 REL SDCBP SMN1 TCF4 TK1 TRIM23	25 interactors: AGO2 CALCOCO2 DDX20 DHX9 DMPK FLAD1 GEMIN5 GLYR1 KARS LGALS1 LGALS3 MORC4 PIAS3 RN7SL1 RNU1-1 RNU2-1 SNRPB SNRPD1 SNRPD2 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TOP1
Entrez ID		80308	50628
HPRD ID		17887	07370
Ensembl ID		ENSG00000160688	ENSG00000179409
Uniprot IDs		Q8NFF5	I3L2C7 P57678 Q8WUM5
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Digestive Tract Development Digestive System Development Ribonucleoprotein Complex Assembly MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Macromolecular Complex Assembly Spliceosomal SnRNP Assembly Negative Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Fetal Process Involved In Parturition RNA Splicing Skeletal Muscle Cell Proliferation Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition MRNA Processing Protein Tetramerization Response To Extracellular Stimulus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Regulation Of Cellular Component Organization Positive Regulation Of Extracellular Vesicular Exosome Assembly Maintenance Of DNA Repeat Elements MRNA Metabolic Process Cell Cycle Arrest Intestinal Epithelial Cell Maturation RNA Processing Positive Regulation Of Signal Transduction Response To Glucocorticoid G1/S Transition Of Mitotic Cell Cycle Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Response To Cortisol Thymidine Metabolic Process Embryonic Hindgut Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Corticosteroid Small GTPase Mediated Signal Transduction Embryonic Genitalia Morphogenesis Response To Toxic Substance Positive Regulation Of Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Cellular Response To UV-B Myoblast Fate Commitment Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Ran GTPase Activity Tube Development Secretory Granule Localization Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage	Spliceosomal SnRNP Assembly RNA Processing MRNA Processing NcRNA Metabolic Process Ribonucleoprotein Complex Assembly MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Biogenesis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecular Complex Assembly Neutrophil Degranulation RNA Metabolic Process Nitrogen Compound Metabolic Process Neutrophil Activation Involved In Immune Response Gene Expression Immune Response Cellular Component Assembly Neutrophil Mediated Immunity Production Of MiRNAs Involved In Gene Silencing By MiRNA Neutrophil Activation Immune System Process Leukocyte Activation Involved In Immune Response Gene Silencing By MiRNA Cellular Response To DsRNA Posttranscriptional Gene Silencing Leukocyte Degranulation Lysyl-tRNA Aminoacylation Negative Regulation Of Immunological Synapse Formation FAD Biosynthetic Process Positive Regulation Of Erythrocyte Aggregation Regulated Secretory Pathway Vesicle Docking Involved In Exocytosis Spliceosomal Complex Assembly Gene Silencing By RNA Cellular Metabolic Process MRNA Cleavage Involved In Gene Silencing By MiRNA Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Diadenosine Tetraphosphate Biosynthetic Process Response To DsRNA Cellular Process Vesicle Docking Membrane Docking SiRNA Loading Onto RISC Involved In RNA Interference Positive Regulation Of Mononuclear Cell Migration Mononuclear Cell Migration
Tagcloud ?			a1 a11 a2 a4 a5 a6 accomplishments annealing annexin annexins carbohydrate conjunction cytoplasm cytoskeleton extensively galectin galectins helicase inside interacting lectin lectins outside phospholipid possesses primer summarizes synexin unwinding
Tagcloud (Difference) ?			a1 a11 a2 a4 a5 a6 accomplishments annealing annexin annexins carbohydrate conjunction cytoplasm cytoskeleton extensively galectin galectins helicase inside interacting lectin lectins outside phospholipid possesses primer summarizes synexin unwinding
Tagcloud (Intersection) ?