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FLAD1 and GRB7
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
FLAD1
GRB7
Gene Name
flavin adenine dinucleotide synthetase 1
growth factor receptor-bound protein 7
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Mitochondrial Matrix
Cytosol
Plasma Membrane
Cytosol
Plasma Membrane
Focal Adhesion
Cytoplasmic Stress Granule
Cell Projection
Molecular Function
FMN Adenylyltransferase Activity
ATP Binding
RNA Binding
SH3/SH2 Adaptor Activity
Protein Binding
Protein Kinase Binding
Phosphatidylinositol Binding
Identical Protein Binding
Biological Process
FAD Biosynthetic Process
Vitamin Metabolic Process
Water-soluble Vitamin Metabolic Process
Riboflavin Metabolic Process
Mo-molybdopterin Cofactor Biosynthetic Process
Small Molecule Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
Blood Coagulation
Positive Regulation Of Signal Transduction
Negative Regulation Of Translation
Positive Regulation Of Cell Migration
Stress Granule Assembly
Leukocyte Migration
Pathways
Metabolism of vitamins and cofactors
Defective CD320 causes methylmalonic aciduria
Defective GIF causes intrinsic factor deficiency
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
Defective HLCS causes multiple carboxylase deficiency
Defective MMAB causes methylmalonic aciduria type cblB
Defective BTD causes biotidinase deficiency
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defective MMAA causes methylmalonic aciduria type cblA
Vitamin B2 (riboflavin) metabolism
Defective CUBN causes hereditary megaloblastic anemia 1
Defective AMN causes hereditary megaloblastic anemia 1
Metabolism of water-soluble vitamins and cofactors
Defective MUT causes methylmalonic aciduria mut type
Defects in biotin (Btn) metabolism
Defective TCN2 causes hereditary megaloblastic anemia
Defects in vitamin and cofactor metabolism
Defects in cobalamin (B12) metabolism
Signaling by PDGF
Signaling by SCF-KIT
Signaling by ERBB2
Downstream signal transduction
GRB7 events in ERBB2 signaling
Tie2 Signaling
Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Protein-Protein Interactions
13 interactors:
ANXA7
CDKN1A
GEMIN4
GRB7
NUDT21
PRTFDC1
RCC1
REL
SDCBP
SMN1
TCF4
TK1
TRIM23
39 interactors:
A1BG
AGAP1
ATP5B
CALM1
CAV1
CPNE6
DOCK7
DYNC1I1
EGFR
ERBB2
ERBB3
FGB
FLAD1
GNB2
GRB2
HADHB
INSR
KCTD6
KIT
KMT2B
LAX1
LY6G6F
MAP3K14
MSH2
PDGFRB
PDHB
PHAX
PKM
PTK2
RET
RND1
RPS2
SETDB1
SHC1
TEK
TLE1
TMSB4X
TRIM36
ZBTB16
Entrez ID
80308
2886
HPRD ID
17887
03311
Ensembl ID
ENSG00000160688
ENSG00000141738
Uniprot IDs
Q8NFF5
Q14451
PDB IDs
1MW4
1WGR
2L4K
2QMS
3PQZ
Enriched GO Terms of Interacting Partners
?
Cellular Component Assembly
Digestive Tract Development
Digestive System Development
Ribonucleoprotein Complex Assembly
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Cellular Macromolecular Complex Assembly
Spliceosomal SnRNP Assembly
Negative Regulation Of Gene Expression
Ribonucleoprotein Complex Biogenesis
Fetal Process Involved In Parturition
RNA Splicing
Skeletal Muscle Cell Proliferation
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
MRNA Processing
Protein Tetramerization
Response To Extracellular Stimulus
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Regulation Of Cellular Component Organization
Positive Regulation Of Extracellular Vesicular Exosome Assembly
Maintenance Of DNA Repeat Elements
MRNA Metabolic Process
Cell Cycle Arrest
Intestinal Epithelial Cell Maturation
RNA Processing
Positive Regulation Of Signal Transduction
Response To Glucocorticoid
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Extracellular Vesicular Exosome Assembly
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Response To Cortisol
Thymidine Metabolic Process
Embryonic Hindgut Morphogenesis
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Response To Corticosteroid
Small GTPase Mediated Signal Transduction
Embryonic Genitalia Morphogenesis
Response To Toxic Substance
Positive Regulation Of Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Cellular Response To UV-B
Myoblast Fate Commitment
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Ran GTPase Activity
Tube Development
Secretory Granule Localization
Pyrimidine Nucleoside Salvage
Pyrimidine-containing Compound Salvage
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Cell Adhesion
Peptidyl-tyrosine Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Phosphorylation
Positive Regulation Of Catalytic Activity
Positive Regulation Of Transferase Activity
Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Intracellular Signal Transduction
Immune System Process
Regulation Of MAPK Cascade
Regulation Of Kinase Activity
Positive Regulation Of Kinase Activity
Fibroblast Growth Factor Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Fc Receptor Signaling Pathway
Regulation Of Protein Phosphorylation
Positive Regulation Of Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Protein Modification Process
Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Response To Fibroblast Growth Factor
Regulation Of Protein Kinase Activity
Neurotrophin TRK Receptor Signaling Pathway
Wound Healing
Immune Response-regulating Signaling Pathway
Neurotrophin Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Protein Metabolic Process
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Cellular Ketone Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Immune System Process
Regulation Of Signal Transduction
Response To Wounding
Regulation Of Cellular Amino Acid Metabolic Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Peptidyl-amino Acid Modification
Signal Transduction By Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Response To Hormone
Regulation Of Cellular Protein Metabolic Process
Tagcloud
?
adapter
appears
avidly
bear
bps
conversely
denote
domain
domains
dramatically
existence
grb10
grb14
homology
interact
interaction
interacts
ir
location
loop
obvious
paired
pleckstrin
resemblance
sh2
summary
unidentified
y1150f
y1151f
Tagcloud (Difference)
?
adapter
appears
avidly
bear
bps
conversely
denote
domain
domains
dramatically
existence
grb10
grb14
homology
interact
interaction
interacts
ir
location
loop
obvious
paired
pleckstrin
resemblance
sh2
summary
unidentified
y1150f
y1151f
Tagcloud (Intersection)
?