FLAD1 and PRTFDC1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		FLAD1	PRTFDC1
Gene Name		flavin adenine dinucleotide synthetase 1	phosphoribosyl transferase domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Cytosol Plasma Membrane	Cytosol
	Molecular Function	FMN Adenylyltransferase Activity ATP Binding	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Homodimerization Activity
	Biological Process	FAD Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Riboflavin Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Small Molecule Metabolic Process	Purine Ribonucleoside Salvage Adenine Salvage Guanine Salvage GMP Salvage IMP Salvage GMP Catabolic Process Hypoxanthine Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Vitamin B2 (riboflavin) metabolism Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: ANXA7 CDKN1A GEMIN4 GRB7 NUDT21 PRTFDC1 RCC1 REL SDCBP SMN1 TCF4 TK1 TRIM23	12 interactors: DTNB EEF2KMT EPM2AIP1 EWSR1 FLAD1 GNPDA1 HPRT1 LGALS9B MCMBP NIF3L1 STAT5A TCL1A
Entrez ID		80308	56952
HPRD ID		17887	17917
Ensembl ID		ENSG00000160688	ENSG00000099256
Uniprot IDs		Q8NFF5	Q9NRG1
PDB IDs			2JBH
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Digestive Tract Development Digestive System Development Ribonucleoprotein Complex Assembly MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Macromolecular Complex Assembly Spliceosomal SnRNP Assembly Negative Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Fetal Process Involved In Parturition RNA Splicing Skeletal Muscle Cell Proliferation Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition MRNA Processing Protein Tetramerization Response To Extracellular Stimulus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Regulation Of Cellular Component Organization Positive Regulation Of Extracellular Vesicular Exosome Assembly Maintenance Of DNA Repeat Elements MRNA Metabolic Process Cell Cycle Arrest Intestinal Epithelial Cell Maturation RNA Processing Positive Regulation Of Signal Transduction Response To Glucocorticoid G1/S Transition Of Mitotic Cell Cycle Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Response To Cortisol Thymidine Metabolic Process Embryonic Hindgut Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Corticosteroid Small GTPase Mediated Signal Transduction Embryonic Genitalia Morphogenesis Response To Toxic Substance Positive Regulation Of Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Cellular Response To UV-B Myoblast Fate Commitment Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Ran GTPase Activity Tube Development Secretory Granule Localization Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage	Positive Regulation Of Mast Cell Differentiation GMP Salvage GMP Catabolic Process Guanine Salvage Glucosamine Catabolic Process FAD Biosynthetic Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Mast Cell Differentiation Adenine Salvage Dihydrobiopterin Metabolic Process Hypoxanthine Salvage Development Of Secondary Male Sexual Characteristics Positive Regulation Of Dopamine Metabolic Process Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Negative Regulation Of Mast Cell Apoptotic Process GMP Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity Creatinine Metabolic Process Regulation Of Mast Cell Apoptotic Process Purine Nucleoside Monophosphate Catabolic Process Glucosamine Metabolic Process Positive Regulation Of Mast Cell Proliferation Riboflavin Metabolic Process Isoleucine Metabolic Process Allantoin Metabolic Process Purine Ribonucleoside Salvage Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Response To Organonitrogen Compound Heterocycle Metabolic Process Negative Regulation Of Erythrocyte Differentiation Prolactin Signaling Pathway GMP Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics Valine Metabolic Process Creatine Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Succinate Metabolic Process Regulation Of Glycogen (starch) Synthase Activity Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics Purine Ribonucleoside Catabolic Process Luteinization Positive Regulation Of Glycogen Biosynthetic Process
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