KAT6A and UBE2U

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		KAT6A	UBE2U
Description		lysine acetyltransferase 6A	ubiquitin conjugating enzyme E2 U
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GO Annotations	Cellular Component	Chromatin Nucleosome Nucleus Nucleoplasm Nucleolus Cytosol PML Body Nuclear Speck MOZ/MORF Histone Acetyltransferase Complex	HULC Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H3 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity DNA-binding Transcription Factor Binding	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation Positive Regulation Of Gene Expression Myeloid Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Developmental Process Chromosome Organization Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Hemopoiesis	Protein Polyubiquitination DNA Repair Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		HATs acetylate histones Regulation of TP53 Activity through Acetylation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Sleep duration ( 30531941)	Severe bacterial meningitis ( 31092817)
Interacting Genes		18 interacting genes: AKT1 ATN1 ATXN1 CREBBP H3-4 H3-5 H3C1 H3C14 H4C1 H4C16 H4C9 HEMGN MAFK PML RERE RUNX1 SPI1 UBE2U	69 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF213 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		7994	148581
HPRD ID		03244	14599
Ensembl ID		ENSG00000083168	ENSG00000177414
Uniprot IDs		A5PKX7 A5PLL3 Q92794	A0A0A0MRP4 A0A140VJY9 Q5VVX9
PDB IDs		1M36 2LN0 2OZU 2RC4 3V43 4LJN 4LK9 4LKA 4LLB 5B75 5B76 5B77 5B78 6LSB 7Y43 8DD5 8H7A 9ARR 9DZN 9FKR	1YRV
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Protein Heterodimerization Activity Nucleosome Nucleoplasm Chromatin Remodeling Nucleosome Assembly Chromatin Organization Nucleosome Organization Protein-DNA Complex Assembly DNA Binding Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Chromosome, Telomeric Region Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Chromosome Regulation Of Megakaryocyte Differentiation Telomere Organization Protein Localization To Chromosome, Centromeric Region Regulation Of Cell Differentiation Regulation Of Cell Development Protein-containing Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Oncogene-induced Cell Senescence Protein Localization To Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Organization Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Regulation Of Hemopoiesis Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Chromatin Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Fibroblast Migration Protein Localization To Chromosome Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Response To Light Stimulus Nuclear Matrix	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Zinc Ion Binding Protein Modification Process Ubiquitin-protein Transferase Activity Metal Ion Binding Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Suppression Of Viral Release By Host Protein Autoubiquitination Catabolic Process Transcription Coactivator Activity Protein K63-linked Ubiquitination Innate Immune Response Protein Catabolic Process Proteasomal Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Other Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Transferase Activity Response To Stress Response To External Biotic Stimulus Immune System Process Protein Sumoylation Immune Response Defense Response Defense Response To Virus Protein K48-linked Ubiquitination PRC1 Complex Regulation Of Type I Interferon Production Cytoplasm Regulation Of Viral Process Positive Regulation Of Catabolic Process Response To Virus PcG Protein Complex Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Viral Process SnoRNA Splicing
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