KAT6A and SPI1

Number of citations of the paper that reports this interaction (PubMedID 16702405)
41

Data Source:
HPRD (in vivo)

		KAT6A	SPI1
Description		lysine acetyltransferase 6A	Spi-1 proto-oncogene
Image
GO Annotations	Cellular Component	Chromatin Nucleosome Nucleus Nucleoplasm Nucleolus Cytosol PML Body Nuclear Speck MOZ/MORF Histone Acetyltransferase Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H3 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding STAT Family Protein Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation Positive Regulation Of Gene Expression Myeloid Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Developmental Process Chromosome Organization Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Hemopoiesis	Negative Regulation Of Transcription By RNA Polymerase II Vasculature Development Germinal Center B Cell Differentiation Follicular B Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Defense Response To Tumor Cell Pro-T Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Lymphocyte Differentiation Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Granulocyte Differentiation Lipopolysaccharide-mediated Signaling Pathway Somatic Stem Cell Population Maintenance TRAIL-activated Apoptotic Signaling Pathway Myeloid Dendritic Cell Differentiation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Neutrophil Degranulation Negative Regulation Of MHC Class II Biosynthetic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Regulation Of Erythrocyte Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Regression Interleukin-6-mediated Signaling Pathway Cellular Response To Ethanol Oncogene-induced Cell Senescence Endothelial To Hematopoietic Transition Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of P38MAPK Cascade Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of MiRNA Transcription Positive Regulation Of Microglial Cell Mediated Cytotoxicity Negative Regulation Of Adipose Tissue Development Pericyte Cell Differentiation Positive Regulation Of Antifungal Innate Immune Response Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Myeloid Dendritic Cell Chemotaxis
Pathways		HATs acetylate histones Regulation of TP53 Activity through Acetylation	RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs
Diseases			Acute myeloid leukemia (AML)
GWAS		Sleep duration ( 30531941)	Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood urea nitrogen levels ( 31152163) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Experiencing mood swings ( 29500382) Familial squamous cell lung carcinoma ( 29924316) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Hematocrit ( 32888494) Hematology traits ( 30576415) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 25173106) Lacunar stroke ( 33773637) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mean platelet volume ( 32888494) Medication use (diuretics) ( 31015401) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		18 interacting genes: AKT1 ATN1 ATXN1 CREBBP H3-4 H3-5 H3C1 H3C14 H4C1 H4C16 H4C9 HEMGN MAFK PML RERE RUNX1 SPI1 UBE2U	47 interacting genes: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FBXW7 FOS FUS GATA1 GATA2 GATA3 GFI1 GSK3B HDAC1 HOXA10 IRF1 IRF2 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 RUNX1 SIN3A SKI SPIB SSRP1 TBP TMX1
Entrez ID		7994	6688
HPRD ID		03244	01305
Ensembl ID		ENSG00000083168	ENSG00000066336
Uniprot IDs		A5PKX7 A5PLL3 Q92794	A0AAA9YHK5 P17947
PDB IDs		1M36 2LN0 2OZU 2RC4 3V43 4LJN 4LK9 4LKA 4LLB 5B75 5B76 5B77 5B78 6LSB 7Y43 8DD5 8H7A 9ARR 9DZN 9FKR	8E3K 8E3R 8E4H 8E5Y 8EBH 8EE9 8EJ6 8EJ8 8EK3 8EK8 8EKJ 8EKU 8EKV 8EKZ 8EM9 8EMD 8ENG 8EO1 8EO4 8EQG 8EQK 8EQL 8T9U 8UFF 8UFK 8UFZ 8UHK 8V9N 8VDH 8VDI
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Protein Heterodimerization Activity Nucleosome Nucleoplasm Chromatin Remodeling Nucleosome Assembly Chromatin Organization Nucleosome Organization Protein-DNA Complex Assembly DNA Binding Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Chromosome, Telomeric Region Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Chromosome Regulation Of Megakaryocyte Differentiation Telomere Organization Protein Localization To Chromosome, Centromeric Region Regulation Of Cell Differentiation Regulation Of Cell Development Protein-containing Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Oncogene-induced Cell Senescence Protein Localization To Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Organization Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Regulation Of Hemopoiesis Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Chromatin Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Fibroblast Migration Protein Localization To Chromosome Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Response To Light Stimulus Nuclear Matrix	Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation DNA-templated Transcription Transcription By RNA Polymerase II Cell Differentiation Sequence-specific DNA Binding Regulation Of Cell Development Regulation Of Hemopoiesis Regulation Of Cell Differentiation Cellular Developmental Process
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