TUBA1A and ZAP70

Number of citations of the paper that reports this interaction (PubMedID 8530437)
0

Data Source:
BioGRID (pull down)

		TUBA1A	ZAP70
Description		tubulin alpha 1a	zeta chain of T cell receptor associated protein kinase 70
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Axonemal Microtubule Cytoplasmic Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Motile Cilium Neuromuscular Junction Sperm Flagellum Cytoplasmic Ribonucleoprotein Granule Cell Projection Synapse Recycling Endosome Extracellular Exosome	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	Nucleotide Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Startle Response Intracellular Protein Transport Microtubule-based Process Centrosome Cycle Smoothened Signaling Pathway Memory Locomotory Behavior Adult Locomotory Behavior Visual Learning Response To Mechanical Stimulus Glial Cell Differentiation Gene Expression Dentate Gyrus Development Cerebellar Cortex Morphogenesis Hippocampus Development Pyramidal Neuron Differentiation Cerebral Cortex Development Neurogenesis Neuron Differentiation Flagellated Sperm Motility Adult Behavior Cytoskeleton-dependent Intracellular Transport Response To Tumor Necrosis Factor Locomotory Exploration Behavior Microtubule Polymerization Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Regulation Of Synapse Organization Synapse Organization Cell Division Neuron Apoptotic Process Motor Behavior Cellular Response To Calcium Ion Organelle Transport Along Microtubule Neuron Projection Arborization Response To L-glutamate	Adaptive Immune Response Immune System Process Protein Phosphorylation Immune Response Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Regulation Of MAPK Cascade Positive Thymic T Cell Selection Negative Thymic T Cell Selection Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration T Cell Aggregation T Cell Migration
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules RHOH GTPase cycle Nuclear events stimulated by ALK signaling in cancer
Drugs		Albendazole Vinblastine Mebendazole Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Artenimol Phenethyl Isothiocyanate Colchiceine	Staurosporine Fostamatinib
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Brain morphology (MOSTest) ( 32665545) Composite immunoglobulin trait (IgG/IgM) ( 28628107)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		66 interacting genes: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CEP20 CLIP1 CNP CPEB2 CXCR1 CYLD DAG1 DUSP23 EGFR EIF4ENIF1 EML1 ENO1 GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LINC01554 LRRK2 MAP7D3 MAPK6 MAPRE1 MAX MX1 MYC NFATC1 NUDT3 OGT PAFAH1B1 PGK1 PLA2G7 PLK2 S100A8 S100A9 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPART STARD13 STK11 SYK SYTL4 TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70	67 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB2 ERBB3 ERBB4 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 KIT LAT LAX1 LCK LCP2 LRRK2 MET MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PELI1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1
Entrez ID		7846	7535
HPRD ID		03959	01495
Ensembl ID		ENSG00000167552	ENSG00000115085
Uniprot IDs		Q71U36	P43403
PDB IDs		5JCO 6J8F 6WSL 7C1M 7UN1 7UNG 8J07 8SH7	1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76 7SIY
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Regulation Of Cell Growth Intracellular Signaling Cassette Microtubule Binding Regulation Of Growth Microtubule Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cellular Component Organization Organelle Organization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Programmed Cell Death Protein-containing Complex Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cytoskeleton Positive Regulation Of Cell Communication Regulation Of Cell Communication Kinase Activity Positive Regulation Of Signaling Regulation Of Signaling Protein Metabolic Process Regulation Of Developmental Process Regulation Of Intrinsic Apoptotic Signaling Pathway Myeloid Leukocyte Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Cell Migration Neutrophil Chemotaxis Developmental Process Cytoplasmic Microtubule Microtubule-based Process Ubiquitin Protein Ligase Binding Catabolic Process Leukocyte Migration Protein Serine/threonine Kinase Activity Protein Kinase Activity Tubulin Binding Negative Regulation Of Cell Growth Cytoskeleton Organization Neutrophil Migration Protein Localization To Nucleus Cellular Developmental Process Microtubule Cytoskeleton Microtubule Positive Regulation Of Apoptotic Process Leukocyte Aggregation Regulation Of Microtubule-based Process	Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Signal Transduction Regulation Of Lymphocyte Activation Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Immune System Process Lymphocyte Activation Cell Activation Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune System Process Regulation Of T Cell Activation Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction T Cell Activation Intracellular Signal Transduction Activation Of Immune Response Plasma Membrane Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Membrane Raft Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Leukocyte Proliferation Regulation Of T Cell Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction SH3 Domain Binding Negative Regulation Of Cell Adhesion Fc Receptor Signaling Pathway Lymphocyte Proliferation Positive Regulation Of Multicellular Organismal Process Mononuclear Cell Proliferation
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