ZAP70 and NFAM1

Number of citations of the paper that reports this interaction (PMID 15143214)
11

Data Source:
HPRD (in vitro)

		ZAP70	NFAM1
Gene Name		zeta-chain (TCR) associated protein kinase 70kDa	NFAT activating protein with ITAM motif 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft	Plasma Membrane Cell Surface Integral Component Of Membrane Membrane Raft
	Molecular Function	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	Transmembrane Signaling Receptor Activity
	Biological Process	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration	Positive Regulation Of Cytokine Production Inflammatory Response Signal Transduction B Cell Differentiation Intracellular Signal Transduction Regulation Of B Cell Differentiation B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Adaptive Immune System
Drugs		Staurosporine
Diseases
GWAS
Protein-Protein Interactions		58 interactors: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP VAV1 WIPF1	2 interactors: SYK ZAP70
Entrez ID		7535	150372
HPRD ID		01495	16380
Ensembl ID		ENSG00000115085	ENSG00000235568
Uniprot IDs		P43403	Q8NET5
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Innate Immune Response Immune Response Positive Regulation Of Immune Response Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Activation Defense Response Fc Receptor Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Regulation Of Signaling Regulation Of T Cell Activation Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Response To Stimulus Leukocyte Activation T Cell Receptor Signaling Pathway Intracellular Signal Transduction Lymphocyte Activation Platelet Activation Blood Coagulation Regulation Of Intracellular Signal Transduction Hemostasis T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Homotypic Cell-cell Adhesion Response To Stress Wound Healing Single Organismal Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation	Beta Selection Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Peptidyl-tyrosine Autophosphorylation T Cell Selection Regulation Of Calcium-mediated Signaling Positive Regulation Of Alpha-beta T Cell Differentiation Alpha-beta T Cell Differentiation Alpha-beta T Cell Activation Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Antigen Receptor-mediated Signaling Pathway Regulation Of T Cell Proliferation T Cell Differentiation Regulation Of Lymphocyte Differentiation Positive Regulation Of T Cell Activation Protein Autophosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Adaptive Immune Response T Cell Aggregation Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Activation Lymphocyte Aggregation Peptidyl-tyrosine Phosphorylation Leukocyte Aggregation Regulation Of T Cell Activation Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Cell Activation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Serotonin Secretion By Platelet Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Lymphocyte Activation Response To Molecule Of Fungal Origin Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Transcription Factor Import Into Nucleus Serotonin Secretion
Tagcloud ?		cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta	aavscc aspirin cigarette cigarettes colon dying interacted itam map3k7 mapk14 mapk8 nfat nfat2 nfat5 nsaid operates recessive rectal rs10508901 rs12447326 rs13208824 rs16959025 rs1800630 rs4149570 superfamily threefold tnfrsf1a traf2 ttvsgg
Tagcloud (Difference) ?		cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta	aavscc aspirin cigarette cigarettes colon dying interacted itam map3k7 mapk14 mapk8 nfat nfat2 nfat5 nsaid operates recessive rectal rs10508901 rs12447326 rs13208824 rs16959025 rs1800630 rs4149570 superfamily threefold tnfrsf1a traf2 ttvsgg
Tagcloud (Intersection) ?