TUBA1A and S100A9

Number of citations of the paper that reports this interaction (PubMedID 15331440)
0

Data Source:
BioGRID (pull down)

		TUBA1A	S100A9
Description		tubulin alpha 1a	S100 calcium binding protein A9
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Axonemal Microtubule Cytoplasmic Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Motile Cilium Neuromuscular Junction Sperm Flagellum Cytoplasmic Ribonucleoprotein Granule Cell Projection Synapse Recycling Endosome Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Secretory Granule Lumen Extracellular Exosome Calprotectin Complex S100A9 Complex
	Molecular Function	Nucleotide Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Antioxidant Activity Toll-like Receptor 4 Binding Metal Ion Binding Calcium-dependent Protein Binding Arachidonate Binding RAGE Receptor Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Startle Response Intracellular Protein Transport Microtubule-based Process Centrosome Cycle Smoothened Signaling Pathway Memory Locomotory Behavior Adult Locomotory Behavior Visual Learning Response To Mechanical Stimulus Glial Cell Differentiation Gene Expression Dentate Gyrus Development Cerebellar Cortex Morphogenesis Hippocampus Development Pyramidal Neuron Differentiation Cerebral Cortex Development Neurogenesis Neuron Differentiation Flagellated Sperm Motility Adult Behavior Cytoskeleton-dependent Intracellular Transport Response To Tumor Necrosis Factor Locomotory Exploration Behavior Microtubule Polymerization Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Regulation Of Synapse Organization Synapse Organization Cell Division Neuron Apoptotic Process Motor Behavior Cellular Response To Calcium Ion Organelle Transport Along Microtubule Neuron Projection Arborization Response To L-glutamate	Immune System Process Leukocyte Migration Involved In Inflammatory Response Chronic Inflammatory Response Autophagy Apoptotic Process Chemotaxis Inflammatory Response Cell-cell Signaling Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Cell Growth Neutrophil Chemotaxis Regulation Of Toll-like Receptor Signaling Pathway Autocrine Signaling Peptidyl-cysteine S-trans-nitrosylation Defense Response To Bacterium Endothelial Cell Migration Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Regulation Of Cytoskeleton Organization Regulation Of Respiratory Burst Involved In Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Aggregation Cellular Oxidant Detoxification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins
Drugs		Albendazole Vinblastine Mebendazole Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Artenimol Phenethyl Isothiocyanate Colchiceine	Calcium Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Brain morphology (MOSTest) ( 32665545) Composite immunoglobulin trait (IgG/IgM) ( 28628107)	Asthma ( 31619474) Basophil percentage of white cells ( 32888494) Matrix metalloproteinase-8 levels ( 29212897)
Interacting Genes		66 interacting genes: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CEP20 CLIP1 CNP CPEB2 CXCR1 CYLD DAG1 DUSP23 EGFR EIF4ENIF1 EML1 ENO1 GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LINC01554 LRRK2 MAP7D3 MAPK6 MAPRE1 MAX MX1 MYC NFATC1 NUDT3 OGT PAFAH1B1 PGK1 PLA2G7 PLK2 S100A8 S100A9 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPART STARD13 STK11 SYK SYTL4 TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70	13 interacting genes: CDC42 EGFR MAGEA1 MAGEA3 MAGEA6 MAPK14 NCF2 PTEN S100A8 S100B SNCA TUBA1A TUBB
Entrez ID		7846	6280
HPRD ID		03959	00472
Ensembl ID		ENSG00000167552	ENSG00000163220
Uniprot IDs		Q71U36	P06702
PDB IDs		5JCO 6J8F 6WSL 7C1M 7UN1 7UNG 8J07 8SH7	1IRJ 1XK4 4GGF 4XJK 5I8N 5W1F 6DS2 7QUV 7UI5 8SJB 8SJC
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Regulation Of Cell Growth Intracellular Signaling Cassette Microtubule Binding Regulation Of Growth Microtubule Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cellular Component Organization Organelle Organization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Programmed Cell Death Protein-containing Complex Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cytoskeleton Positive Regulation Of Cell Communication Regulation Of Cell Communication Kinase Activity Positive Regulation Of Signaling Regulation Of Signaling Protein Metabolic Process Regulation Of Developmental Process Regulation Of Intrinsic Apoptotic Signaling Pathway Myeloid Leukocyte Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Cell Migration Neutrophil Chemotaxis Developmental Process Cytoplasmic Microtubule Microtubule-based Process Ubiquitin Protein Ligase Binding Catabolic Process Leukocyte Migration Protein Serine/threonine Kinase Activity Protein Kinase Activity Tubulin Binding Negative Regulation Of Cell Growth Cytoskeleton Organization Neutrophil Migration Protein Localization To Nucleus Cellular Developmental Process Microtubule Cytoskeleton Microtubule Positive Regulation Of Apoptotic Process Leukocyte Aggregation Regulation Of Microtubule-based Process	Regulation Of Synapse Organization Negative Regulation Of Catabolic Process Cell Projection Morphogenesis Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Growth Neuron Projection Morphogenesis Learning Or Memory Forebrain Morphogenesis RAGE Receptor Binding Regulation Of Growth Dendritic Spine Morphogenesis Cellular Developmental Process Cognition Negative Regulation Of Autophagy Regulation Of Signal Transduction Histone Deacetylase Binding Cell Differentiation Regulation Of Autophagy Dentate Gyrus Development Adult Behavior Regulation Of Cellular Component Organization Enzyme Binding Positive Regulation Of Cell Growth Nucleus Regulation Of Peptidyl-serine Phosphorylation Dendritic Spine Organization Response To Lipid Cytosol Regulation Of Cell Communication Regulation Of Signaling Cell Junction Organization Cell Migration Regulation Of Intracellular Signal Transduction Cytoskeleton-dependent Intracellular Transport Apoptotic Process Negative Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of Cell Population Proliferation Neuron Projection Organization Postsynapse Organization Tau Protein Binding Anatomical Structure Morphogenesis Programmed Cell Death Cell Death Extracellular Region Cytoplasm Response To Cytokine Negative Regulation Of Signaling Negative Regulation Of Cell Communication Multivesicular Body, Internal Vesicle Lumen
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