ZAP70 and PRLR

Number of citations of the paper that reports this interaction (PMID 10221598)
4

Data Source:
HPRD (in vitro)

		ZAP70	PRLR
Gene Name		zeta-chain (TCR) associated protein kinase 70kDa	prolactin receptor
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft	Extracellular Region Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen
	Molecular Function	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	Prolactin Receptor Activity Protein Binding Peptide Hormone Binding Protein Homodimerization Activity Ornithine Decarboxylase Activator Activity Metal Ion Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration	Steroid Biosynthetic Process Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Embryo Implantation Lactation Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Prolactin Signaling Pathway T Cell Activation Activation Of JAK2 Kinase Activity Negative Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development
Pathways		TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Adaptive Immune System	Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling
Drugs		Staurosporine	Somatropin recombinant Fluoxymesterone
Diseases
GWAS
Protein-Protein Interactions		58 interactors: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP VAV1 WIPF1	18 interactors: CISH CREBBP CSH1 FBXW11 GH1 JAK2 NEK3 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		7535	5618
HPRD ID		01495	01457
Ensembl ID		ENSG00000115085	ENSG00000113494
Uniprot IDs		P43403	P16471
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R	1BP3 2LFG 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Innate Immune Response Immune Response Positive Regulation Of Immune Response Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Activation Defense Response Fc Receptor Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Regulation Of Signaling Regulation Of T Cell Activation Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Response To Stimulus Leukocyte Activation T Cell Receptor Signaling Pathway Intracellular Signal Transduction Lymphocyte Activation Platelet Activation Blood Coagulation Regulation Of Intracellular Signal Transduction Hemostasis T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Homotypic Cell-cell Adhesion Response To Stress Wound Healing Single Organismal Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation	JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Hormone Response To Peptide Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Regulation Of JAK-STAT Cascade Response To Organonitrogen Compound Regulation Of Signal Transduction Response To Hormone Cellular Response To Organic Substance Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Signaling Cell Communication Response To Organic Substance Regulation Of Kinase Activity Innate Immune Response Immune System Process Cellular Response To Stimulus Immune Response Regulation Of Body Fluid Levels Wound Healing Defense Response Response To Stimulus Negative Regulation Of JAK-STAT Cascade Regulation Of Cellular Response To Insulin Stimulus Response To Wounding Blood Coagulation Hemostasis Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Phosphorylation Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Protein Modification Process
Tagcloud ?		cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta	abolished cdna cdnas changed cis1 cis2 cis3 cis4 comparable expressions gland glands hint inducible jab little luciferase mammary myc postpartum prolactin reporter responsive sh2 slightly stat5 tagged transfected transiently
Tagcloud (Difference) ?		cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta	abolished cdna cdnas changed cis1 cis2 cis3 cis4 comparable expressions gland glands hint inducible jab little luciferase mammary myc postpartum prolactin reporter responsive sh2 slightly stat5 tagged transfected transiently
Tagcloud (Intersection) ?