TUBA1A and CLIP1

Number of citations of the paper that reports this interaction (PubMedID 16455083)
22

Data Source:
BioGRID (pull down)

		TUBA1A	CLIP1
Description		tubulin alpha 1a	CAP-Gly domain containing linker protein 1
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Axonemal Microtubule Cytoplasmic Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Motile Cilium Neuromuscular Junction Sperm Flagellum Cytoplasmic Ribonucleoprotein Granule Cell Projection Synapse Recycling Endosome Extracellular Exosome	Kinetochore Ruffle Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Cell Cortex Microtubule Cytoskeleton Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Microtubule Plus-end Cell Projection Macropinosome
	Molecular Function	Nucleotide Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Microtubule Binding Zinc Ion Binding Tubulin Binding Identical Protein Binding Metal Ion Binding Microtubule Plus-end Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Startle Response Intracellular Protein Transport Microtubule-based Process Centrosome Cycle Smoothened Signaling Pathway Memory Locomotory Behavior Adult Locomotory Behavior Visual Learning Response To Mechanical Stimulus Glial Cell Differentiation Gene Expression Dentate Gyrus Development Cerebellar Cortex Morphogenesis Hippocampus Development Pyramidal Neuron Differentiation Cerebral Cortex Development Neurogenesis Neuron Differentiation Flagellated Sperm Motility Adult Behavior Cytoskeleton-dependent Intracellular Transport Response To Tumor Necrosis Factor Locomotory Exploration Behavior Microtubule Polymerization Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Regulation Of Synapse Organization Synapse Organization Cell Division Neuron Apoptotic Process Motor Behavior Cellular Response To Calcium Ion Organelle Transport Along Microtubule Neuron Projection Arborization Response To L-glutamate	Mitotic Cell Cycle Microtubule Bundle Formation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases activate IQGAPs RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Signaling by LTK in cancer
Drugs		Albendazole Vinblastine Mebendazole Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Artenimol Phenethyl Isothiocyanate Colchiceine
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Brain morphology (MOSTest) ( 32665545) Composite immunoglobulin trait (IgG/IgM) ( 28628107)	A body shape index ( 34021172) Adiponectin levels ( 31178129) Body fat percentage and HDL-C (pairwise) ( 33619380) Body mass index ( 25673413 26961502) Body mass index and HDL-C (pairwise) ( 33619380) Chronotype ( 30696823) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006) Weight ( 28552196)
Interacting Genes		66 interacting genes: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CEP20 CLIP1 CNP CPEB2 CXCR1 CYLD DAG1 DUSP23 EGFR EIF4ENIF1 EML1 ENO1 GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LINC01554 LRRK2 MAP7D3 MAPK6 MAPRE1 MAX MX1 MYC NFATC1 NUDT3 OGT PAFAH1B1 PGK1 PLA2G7 PLK2 S100A8 S100A9 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPART STARD13 STK11 SYK SYTL4 TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70	13 interacting genes: BIN1 CALM1 CLASP2 CLIP4 DCTN1 IQGAP1 MAPRE2 MTOR PAFAH1B1 REL TSC22D2 TUBA1A TUBB
Entrez ID		7846	6249
HPRD ID		03959	01568
Ensembl ID		ENSG00000167552	ENSG00000130779
Uniprot IDs		Q71U36	B3KXA5 P30622
PDB IDs		5JCO 6J8F 6WSL 7C1M 7UN1 7UNG 8J07 8SH7	2CP5 2CP6 2E3H 2E3I 2E4H 2HQH 2QK0 3E2U 3RDV 8WHH 8WHI
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Regulation Of Cell Growth Intracellular Signaling Cassette Microtubule Binding Regulation Of Growth Microtubule Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cellular Component Organization Organelle Organization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Programmed Cell Death Protein-containing Complex Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cytoskeleton Positive Regulation Of Cell Communication Regulation Of Cell Communication Kinase Activity Positive Regulation Of Signaling Regulation Of Signaling Protein Metabolic Process Regulation Of Developmental Process Regulation Of Intrinsic Apoptotic Signaling Pathway Myeloid Leukocyte Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Cell Migration Neutrophil Chemotaxis Developmental Process Cytoplasmic Microtubule Microtubule-based Process Ubiquitin Protein Ligase Binding Catabolic Process Leukocyte Migration Protein Serine/threonine Kinase Activity Protein Kinase Activity Tubulin Binding Negative Regulation Of Cell Growth Cytoskeleton Organization Neutrophil Migration Protein Localization To Nucleus Cellular Developmental Process Microtubule Cytoskeleton Microtubule Positive Regulation Of Apoptotic Process Leukocyte Aggregation Regulation Of Microtubule-based Process	Microtubule Microtubule Plus-end Binding Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Cytoplasmic Microtubule Cell Leading Edge Cell Cortex Cell Division Microtubule Plus-end Microtubule-based Process Regulation Of Cytoskeleton Organization Neuromuscular Process Cytoskeleton Establishment Of Mitotic Spindle Localization Protein-containing Complex Binding Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Epithelial Cell Migration Organelle Assembly Cellular Component Assembly Establishment Of Spindle Localization Cytoskeleton-dependent Intracellular Transport Spindle Localization Organelle Organization Organelle Localization Regulation Of Epithelial Cell Migration Spindle Positive Regulation Of Keratinocyte Migration Microtubule Binding Microtubule Organizing Center Organization Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Protein Polymerization Regulation Of Microtubule-based Process Establishment Of Organelle Localization Spindle Assembly Establishment Of Localization In Cell Regulation Of Microtubule Polymerization Or Depolymerization Nuclear Membrane Disassembly Regulation Of Synapse Organization Membrane Disassembly Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cellular Component Organization Regulation Of Organelle Organization Response To Calcium Ion Mitotic Spindle Microtubule Anchoring Mitotic Cell Cycle Regulation Of Supramolecular Fiber Organization
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