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ZAP70 and SIT1
Number of citations of the paper that reports this interaction (PubMedID
10209036
)
47
Data Source:
HPRD
(in vivo)
ZAP70
SIT1
Description
zeta chain of T cell receptor associated protein kinase 70
signaling threshold regulating transmembrane adaptor 1
Image
No pdb structure
GO Annotations
Cellular Component
Immunological Synapse
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
T Cell Receptor Complex
Membrane Raft
Plasma Membrane
Membrane
Extracellular Exosome
Molecular Function
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Binding
Kinase Binding
SH2 Domain Binding
Biological Process
Adaptive Immune Response
Immune System Process
Protein Phosphorylation
Immune Response
Leukocyte Cell-cell Adhesion
Peptidyl-tyrosine Phosphorylation
Calcium-mediated Signaling
T Cell Differentiation
Intracellular Signal Transduction
T Cell Activation
B Cell Activation
Beta Selection
Positive Regulation Of MAPK Cascade
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Thymic T Cell Selection
Positive Regulation Of T Cell Differentiation
Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Leukocyte Migration
T Cell Aggregation
T Cell Migration
Adaptive Immune Response
Immune System Process
Signal Transduction
T Cell Homeostasis
Regulation Of T Cell Activation
Pathways
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
RHOH GTPase cycle
Nuclear events stimulated by ALK signaling in cancer
Drugs
Staurosporine
Fostamatinib
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
Bipolar disorder (
31043756
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cardiac Troponin-T levels (
31014085
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Diastolic blood pressure (
30224653
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) (
23648065
)
Interacting Genes
67 interacting genes:
ABL1
ACP1
ANAPC11
APP
ASB3
CARD11
CBL
CBLB
CBLC
CD247
CD3E
CD5
CD79B
CRK
CSK
DAPK1
DBNL
DEF6
DUSP3
EGFR
ERBB2
ERBB3
ERBB4
FCGR3A
FCRL3
FYN
GAB2
GRB2
IFNAR1
KIT
LAT
LAX1
LCK
LCP2
LRRK2
MET
MUC1
NDUFB8
NFAM1
NR0B2
PAG1
PELI1
PLCG1
PRLR
PTK2B
PTPN22
PTPN3
PTPN6
PTPRC
RASA1
RNF41
SH2B3
SH3BP2
SHB
SHC1
SIT1
SLA
SLA2
SLAMF6
SOS1
TUBA1A
TUBA4A
TUBB
TYROBP
USP2
VAV1
WIPF1
17 interacting genes:
APOL2
BMP10
CLRN2
CSK
FYN
GRB2
ITM2A
LCK
MALL
PLN
PTPN11
SYK
TMBIM6
TMEM140
TSPAN33
UPK1B
ZAP70
Entrez ID
7535
27240
HPRD ID
01495
05394
Ensembl ID
ENSG00000115085
ENSG00000137078
Uniprot IDs
P43403
Q9Y3P8
PDB IDs
1FBV
1M61
1U59
2CBL
2OQ1
2OZO
2Y1N
3ZNI
4A4B
4A4C
4K2R
4XZ0
4XZ1
5O76
7SIY
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Antigen Receptor-mediated Signaling Pathway
Signal Transduction
Regulation Of Lymphocyte Activation
Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Leukocyte Activation
Positive Regulation Of Immune System Process
Lymphocyte Activation
Cell Activation
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Immune Response-activating Signaling Pathway
Immune System Process
Regulation Of T Cell Activation
Regulation Of MAPK Cascade
Regulation Of Intracellular Signal Transduction
T Cell Activation
Intracellular Signal Transduction
Activation Of Immune Response
Plasma Membrane
Positive Regulation Of Immune Response
T Cell Receptor Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Membrane Raft
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Cell Activation
Regulation Of Cell-cell Adhesion
Positive Regulation Of Lymphocyte Activation
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
T Cell Costimulation
Leukocyte Proliferation
Regulation Of T Cell Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
SH3 Domain Binding
Negative Regulation Of Cell Adhesion
Fc Receptor Signaling Pathway
Lymphocyte Proliferation
Positive Regulation Of Multicellular Organismal Process
Mononuclear Cell Proliferation
T Cell Costimulation
Non-membrane Spanning Protein Tyrosine Kinase Activity
Phosphotyrosine Residue Binding
Regulation Of T Cell Activation
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Activation
Regulation Of Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Peptidyl-tyrosine Phosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Regulation Of Cell Adhesion
Negative Regulation Of Immune System Process
Leukocyte Activation
Immune Response-activating Signaling Pathway
Phospholipase Binding
Cell Activation
Immune Response-regulating Signaling Pathway
Intracellular Signal Transduction
Activation Of Immune Response
Beta Selection
Cellular Developmental Process
Cell Differentiation
T Cell Receptor Signaling Pathway
Lymphocyte Activation
Fc-gamma Receptor Signaling Pathway
CD8 Receptor Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Localization
Regulation Of Immune System Process
T Cell Activation
Protein Phosphorylation
B Cell Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Regulation Of Immune Response
Regulation Of T Cell Proliferation
Phosphorylation
Enzyme-linked Receptor Protein Signaling Pathway
CD4 Receptor Binding
Positive Regulation Of Gamma-delta T Cell Differentiation
Regulation Of T Cell Differentiation
Regulation Of MAPK Cascade
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Tagcloud (Intersection)
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