ZAP70 and SHB

Number of citations of the paper that reports this interaction (PubMedID 12084069)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		ZAP70	SHB
Description		zeta chain of T cell receptor associated protein kinase 70	SH2 domain containing adaptor protein B
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane T Cell Receptor Complex Membrane Raft	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Phosphotyrosine Residue Binding Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Adaptive Immune Response Immune System Process Protein Phosphorylation Immune Response Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Regulation Of MAPK Cascade Positive Thymic T Cell Selection Negative Thymic T Cell Selection Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration T Cell Aggregation T Cell Migration	Angiogenesis Blood Vessel Development Apoptotic Process Signal Transduction Hemopoiesis Cell Differentiation B Cell Proliferation Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Blood Vessel Morphogenesis T Cell Receptor Signaling Pathway Hematopoietic Stem Cell Proliferation Negative Regulation Of Oocyte Maturation
Pathways		Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules RHOH GTPase cycle Nuclear events stimulated by ALK signaling in cancer	VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway
Drugs		Staurosporine Fostamatinib
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Brain structure ( 20171287) Chronotype ( 30696823) Loneliness (linear analysis) ( 27629369) Longevity (100 years and older) ( 33948810) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		67 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB2 ERBB3 ERBB4 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 KIT LAT LAX1 LCK LCP2 LRRK2 MET MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PELI1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1	27 interacting genes: ABL1 AR CRK EGFR EPS8 ERBB2 ERBB3 ERBB4 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR KIT LAMTOR5 LAT LCP2 MET PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70
Entrez ID		7535	6461
HPRD ID		01495	02635
Ensembl ID		ENSG00000115085	ENSG00000107338
Uniprot IDs		P43403	Q15464
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76 7SIY
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Signal Transduction Regulation Of Lymphocyte Activation Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Immune System Process Lymphocyte Activation Cell Activation Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune System Process Regulation Of T Cell Activation Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction T Cell Activation Intracellular Signal Transduction Activation Of Immune Response Plasma Membrane Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Membrane Raft Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Leukocyte Proliferation Regulation Of T Cell Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction SH3 Domain Binding Negative Regulation Of Cell Adhesion Fc Receptor Signaling Pathway Lymphocyte Proliferation Positive Regulation Of Multicellular Organismal Process Mononuclear Cell Proliferation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of MAPK Cascade Receptor Complex Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Kinase Activity Plasma Membrane ERBB Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Cell Activation Intracellular Signaling Cassette Cell Migration Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Leukocyte Activation Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Protein Phosphorylation Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Phosphorylation Cell Motility Cellular Developmental Process Phosphorylation ERBB2 Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process T Cell Activation Positive Regulation Of Epithelial Cell Proliferation
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