TUBA1A and PGK1

Number of citations of the paper that reports this interaction (PubMedID 11444863)
0

Data Source:
BioGRID (pull down)

		TUBA1A	PGK1
Description		tubulin alpha 1a	phosphoglycerate kinase 1
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Axonemal Microtubule Cytoplasmic Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Motile Cilium Neuromuscular Junction Sperm Flagellum Cytoplasmic Ribonucleoprotein Granule Cell Projection Synapse Recycling Endosome Extracellular Exosome	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Nucleotide Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity	Nucleotide Binding Phosphoglycerate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity ADP Binding Transmembrane Transporter Binding Metal Ion Binding Protein-disulfide Reductase [NAD(P)H] Activity Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Startle Response Intracellular Protein Transport Microtubule-based Process Centrosome Cycle Smoothened Signaling Pathway Memory Locomotory Behavior Adult Locomotory Behavior Visual Learning Response To Mechanical Stimulus Glial Cell Differentiation Gene Expression Dentate Gyrus Development Cerebellar Cortex Morphogenesis Hippocampus Development Pyramidal Neuron Differentiation Cerebral Cortex Development Neurogenesis Neuron Differentiation Flagellated Sperm Motility Adult Behavior Cytoskeleton-dependent Intracellular Transport Response To Tumor Necrosis Factor Locomotory Exploration Behavior Microtubule Polymerization Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Regulation Of Synapse Organization Synapse Organization Cell Division Neuron Apoptotic Process Motor Behavior Cellular Response To Calcium Ion Organelle Transport Along Microtubule Neuron Projection Arborization Response To L-glutamate	Gluconeogenesis Glycolytic Process Negative Regulation Of Angiogenesis Epithelial Cell Differentiation Plasminogen Activation Canonical Glycolysis Cellular Response To Hypoxia Negative Regulation Of Pyruvate Decarboxylation To Acetyl-CoA
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Glycolysis Gluconeogenesis Manipulation of host energy metabolism
Drugs		Albendazole Vinblastine Mebendazole Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Artenimol Phenethyl Isothiocyanate Colchiceine	Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate 3-phospho-D-glyceric acid Copper Artenimol
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)	Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Brain morphology (MOSTest) ( 32665545) Composite immunoglobulin trait (IgG/IgM) ( 28628107)	Mean platelet volume ( 32888494)
Interacting Genes		66 interacting genes: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CEP20 CLIP1 CNP CPEB2 CXCR1 CYLD DAG1 DUSP23 EGFR EIF4ENIF1 EML1 ENO1 GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LINC01554 LRRK2 MAP7D3 MAPK6 MAPRE1 MAX MX1 MYC NFATC1 NUDT3 OGT PAFAH1B1 PGK1 PLA2G7 PLK2 S100A8 S100A9 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPART STARD13 STK11 SYK SYTL4 TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70	22 interacting genes: AR BECN1 CDC7 CEBPA CLIC6 CSNK2A1 DISC1 FNDC3B GAPDH HIF1A HSPH1 LINC01554 NAA10 OGT PCNA RHOU SUMO2 SUMO4 SUPT5H TUBA1A UBE3A YWHAQ
Entrez ID		7846	5230
HPRD ID		03959	02412
Ensembl ID		ENSG00000167552	ENSG00000102144
Uniprot IDs		Q71U36	P00558 V9HWF4
PDB IDs		5JCO 6J8F 6WSL 7C1M 7UN1 7UNG 8J07 8SH7	2WZB 2WZC 2WZD 2X13 2X14 2X15 2XE6 2XE7 2XE8 2Y3I 2YBE 2ZGV 3C39 3C3A 3C3B 3C3C 3ZOZ 4AXX 4O33 5M1R 5M3U 5M6Z 5MXM 5NP8 5O7D 8YHP
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Regulation Of Cell Growth Intracellular Signaling Cassette Microtubule Binding Regulation Of Growth Microtubule Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cellular Component Organization Organelle Organization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Programmed Cell Death Protein-containing Complex Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cytoskeleton Positive Regulation Of Cell Communication Regulation Of Cell Communication Kinase Activity Positive Regulation Of Signaling Regulation Of Signaling Protein Metabolic Process Regulation Of Developmental Process Regulation Of Intrinsic Apoptotic Signaling Pathway Myeloid Leukocyte Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Cell Migration Neutrophil Chemotaxis Developmental Process Cytoplasmic Microtubule Microtubule-based Process Ubiquitin Protein Ligase Binding Catabolic Process Leukocyte Migration Protein Serine/threonine Kinase Activity Protein Kinase Activity Tubulin Binding Negative Regulation Of Cell Growth Cytoskeleton Organization Neutrophil Migration Protein Localization To Nucleus Cellular Developmental Process Microtubule Cytoskeleton Microtubule Positive Regulation Of Apoptotic Process Leukocyte Aggregation Regulation Of Microtubule-based Process	Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Positive Regulation Of Metabolic Process Rhythmic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Protein-containing Complex Response To Metal Ion Negative Regulation Of Nucleobase-containing Compound Metabolic Process Prostate Gland Growth Positive Regulation Of Autophagy Regulation Of Autophagy Organelle Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nucleus Response To Steroid Hormone Cellular Response To Oxidative Stress Negative Regulation Of Macromolecule Biosynthetic Process Response To Ketone TOR Signaling Protein Tag Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Protein Localization To Vacuole Negative Regulation Of Metabolic Process Response To L-glutamate Regulation Of Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Androgen Receptor Signaling Pathway Sin3-type Complex Cellular Response To Chemical Stress Neuron Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Epithelial Cell Maturation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Embryonic Placenta Development Regulation Of Macromolecule Metabolic Process Ubiquitin-like Protein Ligase Binding Positive Regulation Of Signal Transduction Positive Regulation Of Neuroblast Proliferation
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