ZAP70 and GAB2

Number of citations of the paper that reports this interaction (PMID 11572860)
16

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		ZAP70	GAB2
Gene Name		zeta-chain (TCR) associated protein kinase 70kDa	GRB2-associated binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Cell Migration Osteoclast Differentiation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Mast Cell Degranulation Innate Immune Response Phosphatidylinositol-mediated Signaling
Pathways		TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Adaptive Immune System	Signaling by GPCR Signaling by FGFR in disease G-protein beta:gamma signalling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Signaling by SCF-KIT Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Signaling by FGFR1 mutants Interleukin receptor SHC signaling Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants GPVI-mediated activation cascade Interleukin-2 signaling Signaling by FGFR1 fusion mutants Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Innate Immune System
Drugs		Staurosporine
Diseases
GWAS			Alzheimer's disease (late onset) ( 17553421) Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		58 interactors: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP VAV1 WIPF1	28 interactors: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SRC SYK TNFRSF11A ZAP70
Entrez ID		7535	9846
HPRD ID		01495	05866
Ensembl ID		ENSG00000115085	ENSG00000033327
Uniprot IDs		P43403	Q9UQC2
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R	2VWF 2W0Z
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Innate Immune Response Immune Response Positive Regulation Of Immune Response Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Activation Defense Response Fc Receptor Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Regulation Of Signaling Regulation Of T Cell Activation Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Response To Stimulus Leukocyte Activation T Cell Receptor Signaling Pathway Intracellular Signal Transduction Lymphocyte Activation Platelet Activation Blood Coagulation Regulation Of Intracellular Signal Transduction Hemostasis T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Homotypic Cell-cell Adhesion Response To Stress Wound Healing Single Organismal Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Innate Immune Response Fc-epsilon Receptor Signaling Pathway Immune Response Positive Regulation Of Signal Transduction Blood Coagulation Intracellular Signal Transduction Regulation Of Immune System Process Hemostasis Positive Regulation Of Immune System Process Platelet Activation Positive Regulation Of Immune Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of T Cell Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Immune System Process Leukocyte Migration Defense Response T Cell Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Cell-cell Adhesion Wound Healing Regulation Of Cell Activation T Cell Costimulation Regulation Of Cell-cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Response To Wounding Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Signal Transduction Positive Regulation Of Cell Adhesion Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Activation
Tagcloud ?		cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta	adaptor adenocarcinomas compensate contribution deletion demonstrating driven egfr egfrl858r erbb2 erbb3 gab1 inducible initiate inositol member met mutant observations phosphatidyl pi3k plasticity remarkable retained tamoxifen tetracycline tkis tumorigenesis
Tagcloud (Difference) ?		cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta	adaptor adenocarcinomas compensate contribution deletion demonstrating driven egfr egfrl858r erbb2 erbb3 gab1 inducible initiate inositol member met mutant observations phosphatidyl pi3k plasticity remarkable retained tamoxifen tetracycline tkis tumorigenesis
Tagcloud (Intersection) ?